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Chemistry

D-Index
111
Citations
49336
World Ranking
766
National Ranking
308

Overview

Kuo Hsiung Lee was affiliated with the University of Minnesota in the United States. Their research spanned multiple fields, including Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on subfields such as Molecular Biology, Organic Chemistry, Pharmacology, Plant Science, and Infectious Diseases.

The main topics covered in their scientific work included natural product bioactivities and synthesis, HIV/AIDS drug development and treatment, synthesis and biological activity of compounds, bioactive natural diterpenoids research, synthesis of organic compounds, as well as phytochemistry and biological activities related to Ficus species and other phytochemical compounds.

Lee's publication record showed frequent appearances in various venues, with the highest number of publications found in:

  • UNC Libraries
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Journal of Natural Products
  • European Journal of Medicinal Chemistry
  • Medicinal Research Reviews

Among the notable recent papers authored or coauthored by Lee were:

  • Biologically active isoquinoline alkaloids covering 2014-2018, 2020, Medicinal Research Reviews
  • Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses, 2023, Nature Biotechnology
  • Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities, 2020, European Journal of Medicinal Chemistry
  • Development of anti-influenza agents from natural products, 2020, Medicinal Research Reviews
  • Biologically active indolizidine alkaloids, 2020, Medicinal Research Reviews

Lee collaborated frequently with several researchers, reflecting a broad collaborative network. These frequent coauthors included:

  • Susan L. Morris-Natschke
  • Masuo Goto
  • Kyoko Nakagawa-Goto
  • Chin-Ho Chen
  • Keduo Qian

Best Publications

  • Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.

    T. Fujioka;Y. Kashiwada;R. E. Kilkuskie;L. M. Cosentino

  • New developments in the chemistry and biology of the bioactive constituents of Tanshen.

    Xibong Wang;Susan L. Morris-Natschke;Kuo Hsiung Lee

  • Recent progress in the development of coumarin derivatives as potent anti‐HIV agents

    Donglei Yu;Madoka Suzuki;Lan Xie;Susan L. Morris-Natschke

  • Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.

    Yoshiki Kashiwada;Akihiro Aoshima;Yasumasa Ikeshiro;Yuh Pan Chen

  • 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

    Mann-Jen Hour;Li-Jiau Huang;Sheng-Chu Kuo;Yi Xia

  • Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.

    Y Kashiwada;H K Wang;T Nagao;S Kitanaka

  • Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos

    Jiu Hong Wu;Xi Hong Wang;Yang Hua Yi;Kuo-Hsiung Lee

  • Biologically active quinoline and quinazoline alkaloids part I

    Xiao Fei Shang;Susan L. Morris-Natschke;Ying Qian Liu;Xiao Guo

  • Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

    Y. Kashiwada;F. Hashimoto;L. M. Cosentino;Chin-Ho Chen

  • Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis

    Junko Ito;Fang-Rong Chang;Hui-Kang Wang;Yong Kun Park

  • Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

    Hironori Ohtsu;Zhiyan Xiao;Junko Ishida;Masahiro Nagai

  • Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach

    Kuo Hsiung Lee

  • Recent discovery of plant-derived anti-diabetic natural products

    Hsin Yi Hung;Keduo Qian;Susan L. Morris-Natschke;Chau Shin Hsu

  • Antitumor Agents. 181. † Synthesis and Biological Evaluation of 6,7,2',3',4'-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

    Yi Xia;Zheng Yu Yang;Peng Xia;Kenneth F. Bastow

  • Sesquiterpene antitumor agents: inhibitors of cellular metabolism

    Kuo Hsiung Lee;Iris H. Hall;Eng Chun Mar;Charles O. Starnes

  • Cytotoxicity of Sesquiterpene Lactones

    Kuo-Hsiung Lee;Eng-Shang Huang;Claude Piantadosi;Joseph S. Pagano

  • Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.

    Gen Ichiro Nonaka;Itsuo Nishioka;Makoto Nishizawa;Takashi Yamagishi

  • Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

    Xihong Wang;Kenneth F. Bastow;Chang Ming Sun;Yun Lian Lin

  • Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin

    Sheng Chu Kuo;Hong Zin Lee;Jung Pin Juang;Yih Tyng Lin

  • Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia

    Ping Chung Kuo;Amooru G. Damu;Kuo Hsiung Lee;Tian Shung Wu

  • Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

    Chang Qi Hu;K. E. Chen;Qian Shi;Robert E. Kilkuskie

Frequent Co-Authors

Susan L. Morris-Natschke
Susan L. Morris-Natschke University of North Carolina at Chapel Hill
Kenneth F. Bastow
Kenneth F. Bastow University of North Carolina at Chapel Hill
Chin Ho Chen
Chin Ho Chen Duke University
Tian Shung Wu
Tian Shung Wu National Cheng Kung University
Sheng-Chu Kuo
Sheng-Chu Kuo China Medical University
Yoshiki Kashiwada
Yoshiki Kashiwada University of Tokushima
Andrew T. McPhail
Andrew T. McPhail Duke University
Yang Chang Wu
Yang Chang Wu China Medical University
Yung-Chi Cheng
Yung-Chi Cheng Yale University
Ernest Hamel
Ernest Hamel National Institutes of Health

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