World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
66
Citations
13107
World Ranking
7430
National Ranking
62

Biology and Biochemistry

D-Index
69
Citations
13772
World Ranking
7554
National Ranking
31

Overview

Sheng-Chu Kuo is affiliated with China Medical University in Taiwan and has contributed extensively to research in biochemistry, genetics, molecular biology, medicine, and chemistry. Their work primarily focuses on molecular biology and organic chemistry, with significant contributions to molecular medicine, infectious diseases, and oncology.

The scientist has published in several frequent venues, including:

  • Biomedicine
  • UNC Libraries
  • Oncology Reports
  • Molecules
  • Chemical Biology & Drug Design

Kuo has participated in research on diverse biomedical topics with main themes covering:

  • Curcumin's Biomedical Applications
  • Retinoids in leukemia and cellular processes
  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • COVID-19 Clinical Research Studies
  • Andrographolide Research and Applications

Frequent coauthors collaborating with Kuo include:

  • Jai-Sing Yang
  • Yu-Jen Chiu
  • Min-Tsang Hsieh
  • Chi-Cheng Lu
  • Fuu-Jen Tsai

Kuo's recent papers span topics related to COVID-19, cancer research, and pharmacological compounds. Notable publications include:

  • "Approaches towards fighting the COVID-19 pandemic (Review)" (2020), International Journal of Molecular Medicine
  • "Analysis of COVID-19 prevention and treatment in Taiwan (Review)" (2021), Biomedicine
  • "Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells" (2021), Oncology Reports
  • "Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives" (2020), Molecules
  • "In silico and in vitro studies of Taiwan Chingguan Yihau (NRICM101) on TNF-α/IL-1β-induced Human Lung Cells" (2022), Biomedicine

Their publications reflect ongoing investigations into natural compounds such as curcuminoids and their biomedical applications, particularly in anticancer activities and inflammation modulation.

Best Publications

  • YC-1, a novel activator of platelet guanylate cyclase.

    Feng-Nien Ko;Chin-Chung Wu;Sheng-Chu Kuo;Fang-Yu Lee

  • 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

    Mann-Jen Hour;Li-Jiau Huang;Sheng-Chu Kuo;Yi Xia

  • STUDIES ON HETEROCYCLIC COMPOUNDS. 6. SYNTHESIS AND ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES OF 3,4‐DIMETHYLPYRANO(2,3‐C)PYRAZOL‐6‐ONE DERIVATIVES

    S.-C. Kuo;L.-J. Huang;H. Nakamura

  • YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase.

    Chin-Chung Wu;Feng-Nien Ko;Sheng-Chu Kuo;Fang-Yu Lee

  • Antitumor Agents. 181. † Synthesis and Biological Evaluation of 6,7,2',3',4'-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

    Yi Xia;Zheng Yu Yang;Peng Xia;Kenneth F. Bastow

  • Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin

    Sheng Chu Kuo;Hong Zin Lee;Jung Pin Juang;Yih Tyng Lin

  • Antitumor Agents. Part 204: Synthesis and Biological Evaluation of Substituted 2-Aryl Quinazolinones

    Yi Xia;Zheng Yu Yang;Mann Jen Hour;Sheng Chu Kuo

  • Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera.

    Shiuh-Chuan Chan;Yuan-Shiun Chang;Jih-Pyang Wang;Sheng-Chih Chen

  • Antiplatelet components in Panax ginseng.

    Sheng-Chu Kuo;Che-Ming Teng;Jang-Chang Lee;Feng-Nien Ko

  • Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.

    Fang-Yu Lee;Jin-Cherng Lien;Li-Jiau Huang;Tsang-Miao Huang

  • YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia

    Unknown

  • Cytotoxicity of Ganoderma lucidum triterpenes

    Tian-Shung Wu;Li-Shian Shi;Sheng-Chu Kuo

  • Antioxidant properties of butein isolated from Dalbergia odorifera

    Zhi-Jiao Cheng;Sheng-Chu Kuo;Shiuh-Chuan Chan;Feng-Nien Ko

  • Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication.

    Chih-Chun Wen;Lie-Fen Shyur;Jia-Tsrong Jan;Po-Huang Liang

  • Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

    Leping Li;Hui Kang Wang;Sheng Chu Kuo;Tian-Shung Wu

  • Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

    Leping Li;Hui Kang Wang;Sheng Chu Kuo;Tian Shung Wu

  • Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng.

    Che-Ming Teng;Sheng-Chu Kuo;Feng-Nien Ko;Jan-Chang Lee

  • Synthesis and antiplatelet activity of phenyl quinolones

    Li Jiau Huang;Ming Chieh Hsieh;Che Ming Teng;Kuo Hsiung Lee

  • Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

    Chi-Sheng Shia;Shang-Yuan Tsai;Sheng-Chu Kuo;Yu-Chi Hou

  • Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.

    Shun Xiang Zhang;Jun Feng;Sheng Chu Kuo;Arnold Brossi

  • YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice

    Che-Ming Teng;Chin-Chung Wu;Feng-Nien Ko;Fang-Yu Lee

Frequent Co-Authors

Che-Ming Teng
Che-Ming Teng National Taiwan University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Jai Sing Yang
Jai Sing Yang China Medical University
Tian Shung Wu
Tian Shung Wu National Cheng Kung University
Jing Gung Chung
Jing Gung Chung China Medical University
Tur-Fu Huang
Tur-Fu Huang National Taiwan University
Chi-Tang Ho
Chi-Tang Ho Rutgers, The State University of New Jersey
Susan L. Morris-Natschke
Susan L. Morris-Natschke University of North Carolina at Chapel Hill
Ernest Hamel
Ernest Hamel National Institutes of Health
Fuu Jen Tsai
Fuu Jen Tsai China Medical University

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