World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Medicine
Taiwan
2026

D-Index & Metrics

Best Scientists

D-Index
176
Citations
113519
World Ranking
692
National Ranking
1

Molecular Biology

D-Index
178
Citations
114158
World Ranking
37
National Ranking
1

Medicine

D-Index
179
Citations
117880
World Ranking
380
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Medicine in Taiwan Leader Award
  • 2026 - Research.com Molecular Biology in Taiwan Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Taiwan Leader Award
  • 2025 - Research.com Molecular Biology in Taiwan Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Taiwan Leader Award
  • 2023 - Research.com Medicine in Taiwan Leader Award
  • 2023 - Research.com Molecular Biology in Taiwan Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Taiwan Leader Award
  • 2022 - Research.com Medicine in Taiwan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Enzyme

His scientific interests lie mostly in Cancer research, Cell biology, Cancer cell, Cancer and Signal transduction. His Cancer research research is multidisciplinary, relying on both Protein kinase B, Phosphorylation, Cell growth, Transcription factor and Breast cancer. His work carried out in the field of Protein kinase B brings together such families of science as Carcinogenesis, PI3K/AKT/mTOR pathway and Trastuzumab.

His studies examine the connections between Breast cancer and genetics, as well as such issues in Immunology, with regards to Ductal carcinoma. His study in Cell biology is interdisciplinary in nature, drawing from both Histone H3, Ubiquitin, Downregulation and upregulation, microRNA and Regulation of gene expression. In his research on the topic of Cancer cell, Pathology is strongly related with Metastasis.

His most cited work include:

  • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients (1523 citations)
  • Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition (1248 citations)
  • Requirement for neuregulin receptor erbB2 in neural and cardiac development (1130 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Cancer research, Cancer, Cancer cell, Cell biology and Breast cancer. The concepts of his Cancer research study are interwoven with issues in Cell growth, Carcinogenesis, Immunology, Signal transduction and Metastasis. His Cancer research includes themes of Genetic enhancement and Pathology.

His Cancer cell study incorporates themes from Cell culture, Apoptosis, Downregulation and upregulation, Molecular biology and Immunotherapy. The study incorporates disciplines such as Ubiquitin and Ubiquitin ligase in addition to Cell biology. His biological study spans a wide range of topics, including Tyrosine kinase and Epidermal growth factor receptor.

He most often published in these fields:

  • Cancer research (91.81%)
  • Cancer (30.86%)
  • Cancer cell (28.54%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cancer research (91.81%)
  • Cancer (30.86%)
  • Cancer cell (28.54%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cancer research, Cancer, Cancer cell, Cell biology and Immune checkpoint. The Cancer research study combines topics in areas such as PD-L1, Immune system, Immunotherapy, Metastasis and Breast cancer. His Cancer study combines topics in areas such as Juxtacrine signalling, Programmed cell death and Erythropoietin-producing hepatocellular receptor.

His Cancer cell research incorporates themes from Apoptosis, Targeted therapy, Cell and DNA damage. His research investigates the connection between Cell biology and topics such as Mutation that intersect with problems in Mutant. His Carcinogenesis research is multidisciplinary, incorporating perspectives in PI3K/AKT/mTOR pathway and Cell growth.

Between 2016 and 2021, his most popular works were:

  • PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression (324 citations)
  • Long noncoding RNA MALAT1 suppresses breast cancer metastasis (197 citations)
  • Long noncoding RNA MALAT1 suppresses breast cancer metastasis (197 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Enzyme

His main research concerns Cancer research, Cancer cell, Cell biology, Metastasis and PD-L1. His Cancer research research includes elements of Immune checkpoint, Cancer, Breast cancer, Immunotherapy and Downregulation and upregulation. His Cancer cell research incorporates elements of DNA damage and Oncology.

His Cell biology study combines topics from a wide range of disciplines, such as Transcription, Regulation of gene expression and Ubiquitin, Ubiquitin ligase. His work deals with themes such as Carcinogenesis, Osteoclast, Colorectal cancer and Receptor tyrosine kinase-like orphan receptor, which intersect with Metastasis. His research in PD-L1 intersects with topics in Cell culture and Cancer immunotherapy.

Best Publications

  • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

    Yoichi Nagata;Keng Hsueh Lan;Xiaoyan Zhou;Ming Tan

  • Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

    Binhua P. Zhou;Jiong Deng;Weiya Xia;Jihong Xu

  • The neu oncogene encodes an epidermal growth factor receptor-related protein.

    Cornelia I. Bargmann;Mien Chie Hung;Robert A. Weinberg

  • Requirement for neuregulin receptor erbB2 in neural and cardiac development

    Kuo Fen Lee;Horst Simon;Hua Chen;Brian Bates

  • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

    Binhua P. Zhou;Yong Liao;Weiya Xia;Bill Spohn

  • Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

    Cornelia I. Bargmann;Mien Chie Hung;Robert A. Weinberg

  • Nuclear localization of EGF receptor and its potential new role as a transcription factor

    Shiaw Yih Lin;Keishi Makino;Weiya Xia;Angabin Matin

  • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

    Alicia M. Viloria Petit;Janusz Rak;Mien Chie Hung;Patricia Rockwell

  • Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer

    Rita Nahta;Dihua Yu;Mien Chie Hung;Gabriel N. Hortobagyi

  • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

    Katherine Stemke-Hale;Ana Maria Gonzalez-Angulo;Ana Lluch;Richard M. Neve

  • HER-2 / neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

    Binhua P. Zhou;Yong Liao;Weiya Xia;Yiyu Zou

  • Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

    Sao Jiralerspong;Shana L. Palla;Sharon Hermes Giordano;Funda Meric-Bernstam

  • IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

    Mickey C.T. Hu;Dung Fang Lee;Weiya Xia;Leonard S. Golfman

  • β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

    Shiaw Yih Lin;Weiya Xia;Jo C. Wang;Ka Yin Kwong

  • Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

    Chia Wei Li;Seung Oe Lim;Weiya Xia;Heng Huan Lee

  • The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines

    Kristina Subik;Jin Feng Lee;Laurie Baxter;Tamera Strzepek

  • Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

    Hui Wen Lo;Sheng Chieh Hsu;Weiya Xia;Xinyu Cao

  • p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs

    Chun Ju Chang;Chi Hong Chao;Weiya Xia;Jer Yen Yang;Jer Yen Yang

  • PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression

    Shiping Jiao;Shiping Jiao;Weiya Xia;Hirohito Yamaguchi;Yongkun Wei

  • PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients.

    Keng-Hsueh Lan;Yoichi Nagata;Xiaoyan Zhou;Francisco J. Esteva

Frequent Co-Authors

Weiya Xia
Weiya Xia The University of Texas MD Anderson Cancer Center
Dihua Yu
Dihua Yu The University of Texas MD Anderson Cancer Center
Yongkun Wei
Yongkun Wei The University of Texas MD Anderson Cancer Center
Gabriel N. Hortobagyi
Gabriel N. Hortobagyi The University of Texas MD Anderson Cancer Center
Dung Fang Lee
Dung Fang Lee The University of Texas Health Science Center at Houston
Jun Yao
Jun Yao The University of Texas MD Anderson Cancer Center
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Aysegul A. Sahin
Aysegul A. Sahin The University of Texas MD Anderson Cancer Center
Chang Hai Tsai
Chang Hai Tsai Asian University
Binhua P. Zhou
Binhua P. Zhou University of Kentucky

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