His primary areas of study are Signal transduction, Cancer research, Cell biology, Downregulation and upregulation and Cell growth. In general Signal transduction, his work in PI3K/AKT/mTOR pathway and ErbB is often linked to ROR1 linking many areas of study. His Cancer research research is multidisciplinary, relying on both I-Kappa-B Kinase, Akt/PKB signaling pathway, CHUK, Hypertelorism and PTPN11.
His Cell biology research incorporates themes from Ubiquitin, Ubiquitin ligase, Carcinogenesis, Reprogramming and IκB kinase. His work focuses on many connections between Downregulation and upregulation and other disciplines, such as MAPK/ERK pathway, that overlap with his field of interest in Catenin, Oncogene, Beta-catenin and Transplantation. His studies deal with areas such as Receptor tyrosine kinase and Phosphorylation as well as Catenin.
Dung Fang Lee mainly focuses on Cancer research, Cell biology, Induced pluripotent stem cell, Signal transduction and Carcinogenesis. His biological study spans a wide range of topics, including Cancer, Metastasis, Cell growth, Downregulation and upregulation and Phosphorylation. His Downregulation and upregulation research is multidisciplinary, incorporating elements of Oncogene, Mdm2, Transplantation and MAPK/ERK pathway.
The concepts of his Cell biology study are interwoven with issues in Embryonic stem cell, Ubiquitin, IκB kinase and Homeobox protein NANOG. His work carried out in the field of Signal transduction brings together such families of science as Molecular biology, Kinase, Beta-Transducin Repeat-Containing Proteins and Transactivation. Dung Fang Lee interconnects Germline mutation, Wnt signaling pathway, Angiogenesis and GSK-3 in the investigation of issues within Carcinogenesis.
Cancer research, Induced pluripotent stem cell, Cell biology, Cancer and Osteosarcoma are his primary areas of study. His Cancer research study integrates concerns from other disciplines, such as Germline mutation, Carcinogenesis, Transcriptome, Metastasis and Notch signaling pathway. The Induced pluripotent stem cell study combines topics in areas such as Angiogenesis, Disease, Pathogenesis and Li–Fraumeni syndrome.
His Cell biology study combines topics from a wide range of disciplines, such as Mutation, Embryonic stem cell, Oxidative phosphorylation and Germ layer. His Cancer research includes elements of Genome editing, Reprogramming, Cellular differentiation and Bioinformatics. In his research, Mitochondrion and Downregulation and upregulation is intimately related to Pediatric cancer, which falls under the overarching field of Mesenchymal stem cell.
Dung Fang Lee spends much of his time researching Induced pluripotent stem cell, Cancer research, Bioinformatics, Stem cell and Genome editing. Dung Fang Lee combines subjects such as Cancer, Cancer Etiology, Pathogenesis and Human disease, Disease with his study of Induced pluripotent stem cell. His work on Osteosarcoma as part of general Cancer research study is frequently linked to AKT2, therefore connecting diverse disciplines of science.
Dung Fang Lee interconnects Intrahepatic Cholangiocarcinoma, Genomic profiling, Advanced stage, Cause of death and Liver cancer in the investigation of issues within Bioinformatics. His Stem cell research is multidisciplinary, incorporating perspectives in DNA-binding protein, Transcription factor, Zinc finger, Chromatin and Molecular biology. Dung Fang Lee focuses mostly in the field of Genome editing, narrowing it down to topics relating to Cellular differentiation and, in certain cases, Cell, Retinoblastoma, Cell biology, Cas9 and Germline.
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IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Mickey C.T. Hu;Dung Fang Lee;Weiya Xia;Leonard S. Golfman.
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
Xonia Carvajal-Vergara;Ana Sevilla;Sunita L. Dsouza;Yen Sin Ang.
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Dung Fang Lee;Hsu Ping Kuo;Hsu Ping Kuo;Chun Te Chen;Chun Te Chen;Jung Mao Hsu;Jung Mao Hsu.
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer Yen Yang;Cong S. Zong;Weiya Xia;Hirohito Yamaguchi.
Nature Cell Biology (2008)
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Qingqing Ding;Weiya Xia;Jaw Ching Liu;Jer Yen Yang;Jer Yen Yang.
Molecular Cell (2005)
Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network
Yen Sin Ang;Su Yi Tsai;Dung Fang Lee;Jonathan Monk.
KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
Jianhua Ling;Ya'an Kang;Ruiying Zhao;Qianghua Xia.
Cancer Cell (2012)
Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization
Qingqing Ding;Xianghuo He;Jung Mao Hsu;Jung Mao Hsu;Weiya Xia.
Molecular and Cellular Biology (2007)
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
Shao Chun Wang;Huang Chun Lien;Weiya Xia;I. Fen Chen.
Cancer Cell (2004)
KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
Dung Fang Lee;Hsu Ping Kuo;Hsu Ping Kuo;Mo Liu;Mo Liu;Chao Kai Chou;Chao Kai Chou.
Molecular Cell (2009)
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