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Overview

Hirofumi Nakano is affiliated with Jichi Medical University in Japan. Their research primarily focuses on the field of Medicine, with particular attention to Infectious Diseases and Pharmacology as subfields of study.

The scientist's research work concentrates on topics related to COVID-19 Clinical Research Studies, SARS-CoV-2 and COVID-19 Research, and Drug-Induced Hepatotoxicity and Protection.

Notable recent publications by Hirofumi Nakano include:

  • Autoimmune Hemolytic Anemia Induced by COVID-19 Vaccination, 2024, Kansenshogaku zasshi
  • Asbestos in organochlorine insecticide powder sprinkled between pages of antiquarian books in a library in Japan, 2024, Industrial Health
  • Efficacy of oral antivirals and combination therapy with remdesivir in hematological patients with COVID-19, 2025, Journal of Infection and Chemotherapy

Frequent co-authors include:

  • Yui Imai
  • Morihiro Inoue
  • Masao Hagihara
  • Hiroyoshi Hayashi
  • Takeshi Murakami

Hirofumi Nakano's work has appeared in the following publication venues:

  • Kansenshogaku zasshi
  • Industrial Health
  • Journal of Infection and Chemotherapy

Best Publications

  • Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.

    Eiji Kobayashi;Hirofumi Nakano;Makoto Morimoto;Tatsuya Tamaoki

  • Inhibition of protein kinase C by calphostin C is light-dependent.

    Robert F. Bruns;F.Dean Miller;Ronald L. Merriman;J.Jeffry Howbert

  • Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol.

    Sreenath V Sharma;Tsutomu Agatsuma;Hirofumi Nakano

  • STAUROSPORINE INHIBITS TYROSINE-SPECIFIC PROTEIN KINASE ACTIVITY OF ROUS SARCOMA VIRUS TRANSFORMING PROTEIN p60

    Hirofumi Nakano;Eiji Kobayashi;Isami Takahashi;Tatsuya Tamaoki

  • Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

    Tatsuya Tamaoki;Hirofumi Nakano

  • Hypericin and pseudohypericin specifically inhibit protein kinase C: Possible relation to their antiretroviral activity

    Isami Takahashi;Satoshi Nakanishi;Eiji Kobayashi;Hirofumi Nakano

  • UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

    Isami Takahashi;Eiji Kobayashi;Kozo Asano;Mayumi Yoshida

  • Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp.

    Michio Ichimura;Tatsuhiro Ogawa;Kei-Ichi Takahashi;Eiji Kobayashi

  • Duocarmycin A, a new antitumor antibiotic from Streptomyces.

    Isami Takahashi;Kei-Ichi Takahashi;Michio Ichimura;Makoto Morimoto

  • Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine

    Hirofumi Nakano;Satoshi Omura

  • UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

    Isami Takahashi;Yutaka Saitoh;Mayumi Yoshida;Hiroshi Sano

  • Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives.

    Yoshinori Yamashita;Noboru Fujii;Chikara Murakata;Tadashi Ashizawa

  • Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.

    Eiji Kobayashi;Katsuhiko Ando;Hirofumi Nakano;Takao Iida

  • Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.

    Yoshinori Yamashita;Shozou Kawada;Noboru Fujii;Hirofumi Nakano

  • Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.

    Mitsunobu Kara;Kozo Asano;Isao Kawamoto;Toshimitsu Takiouchi

  • DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.

    Mitsunobu Hara;Isami Takahashi;Mayumi Yoshida;Kozo Asano

  • UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.

    Isami Takahashi;Kozo Asano;Isao Kawamoto;Tatsuya Tamaoki

  • Purification of docosahexaenoic acid by selective esterification of fatty acids from tuna oil with Rhizopus delemar lipase

    Yuji Shimada;Akio Sugihara;Hirofumi Nakano;Takashi Kuramoto

  • Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway

    Shiro Soga;Takako Kozawa;Hiroaki Narumi;Shiro Akinaga

  • Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity.

    Yoshinori Yamashita;Tadashi Ashizawa;Makoto Morimoto;Jiro Hosomi

Frequent Co-Authors

Yuji Shimada
Yuji Shimada Osaka University
Akio Sugihara
Akio Sugihara Tokushima Bunri University
Makoto Kiso
Makoto Kiso Gifu University
Hideharu Ishida
Hideharu Ishida Gifu University
Yasuo Suzuki
Yasuo Suzuki Chubu University
Fusao Tomita
Fusao Tomita Hokkaido University
Keiko Nishikawa
Keiko Nishikawa Chiba University
Yoshihiro Kawaoka
Yoshihiro Kawaoka University of Tokyo
Satoshi Omura
Satoshi Omura Kitasato University
Yoichi Matsuda
Yoichi Matsuda Nagoya University

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