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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
15827
World Ranking
16948
National Ranking
6983

Overview

Yongkun Wei is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple fields within medicine, with a particular focus on oncology and molecular biology. Their scholarly output includes work on cancer immunotherapy, epigenetics, and biochemical mechanisms related to cancer development and treatment.

The primary fields of study for Yongkun Wei include Medicine and Biochemistry, Genetics and Molecular Biology. Within these, their subfields of expertise cover Oncology, Molecular Biology, Immunology, Surgery, and Cell Biology.

Key topics addressed in their research encompass:

  • Cancer Immunotherapy and Biomarkers
  • Epigenetics and DNA Methylation
  • PARP inhibition in cancer therapy
  • Phagocytosis and Immune Regulation
  • Immunotherapy and Immune Responses
  • Hippo pathway signaling and YAP/TAZ
  • Pancreatic and Hepatic Oncology Research

Yongkun Wei has authored several papers in high-impact venues, including:

  • The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis, 2020, Nature
  • TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis, 2021, Journal of Clinical Investigation
  • Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer, 2021, Oncogene
  • Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases, 2020, Science Translational Medicine
  • miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt/β-catenin axis, 2021, Aging

Their frequent coauthors reflect ongoing collaborations and include:

  • Mien-Chie Hung
  • Jun Yao
  • Dihua Yu
  • Weiya Xia
  • Haoqiang Ying

Yongkun Wei's work has been published multiple times in leading journals such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Investigation, Nature Communications, and PubMed. Their engagement with these venues reflects a consistent focus on cancer biology and immunology research.

Best Publications

  • Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

    Hui Wen Lo;Sheng Chieh Hsu;Weiya Xia;Xinyu Cao

  • PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression

    Shiping Jiao;Shiping Jiao;Weiya Xia;Hirohito Yamaguchi;Yongkun Wei

  • IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

    Dung Fang Lee;Hsu Ping Kuo;Hsu Ping Kuo;Chun Te Chen;Chun Te Chen;Jung Mao Hsu;Jung Mao Hsu

  • BAP1 links metabolic regulation of ferroptosis to tumour suppression.

    Yilei Zhang;Jiejun Shi;Xiaoguang Liu;Li Feng

  • Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis

    Yan M. Li;Yong Pan;Yongkun Wei;Xiaoyun Cheng;Xiaoyun Cheng

  • Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.

    Hui Wen Lo;Sheng Chieh Hsu;Mohamed Ali-Seyed;Mehmet Gunduz

  • Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

    Jong-Ho Cha;Wen-Hao Yang;Weiya Xia;Yongkun Wei

  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

    Aifu Lin;Chunlai Li;Zhen Xing;Qingsong Hu

  • LncRNA directs cooperative epigenetic regulation downstream of chemokine signals

    Zhen Xing;Aifu Lin;Chunlai Li;Ke Liang

  • ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

    Peijing Zhang;Yongkun Wei;L. i. Wang;Bisrat G. Debeb

  • LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

    Dahu Chen;Yutong Sun;Yongkun Wei;Peijing Zhang

  • CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

    Yongkun Wei;Ya Huey Chen;Long Yuan Li;Long Yuan Li;Jingyu Lang

  • Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.

    Yi Yang;Chia Wei Li;Li Chuan Chan;Li Chuan Chan;Yongkun Wei

  • Novel Prognostic Value of Nuclear Epidermal Growth Factor Receptor in Breast Cancer

    Hui Wen Lo;Weiya Xia;Yongkun Wei;Mohamed Ali-Seyed

  • Loss of Trimethylation at Lysine 27 of Histone H3 Is a Predictor of Poor Outcome in Breast, Ovarian, and Pancreatic Cancers

    Yongkun Wei;Weiya Xia;Zhihong Zhang;Jinsong Liu

  • Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

    Heng Huan Lee;Ying Nai Wang;W. Xia;Chia Hung Chen

  • IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

    Li Chuan Chan;Chia Wei Li;Weiya Xia;Jung Mao Hsu

  • Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

    Ge Zhou;Jiping Wang;Mei Zhao;Tong Xin Xie

  • MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation

    Jer Yen Yang;Cong S. Zong;Weiya Xia;Yongkun Wei

  • The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

    Daqian Xu;Daqian Xu;Zheng Wang;Yan Xia;Fei Shao

Frequent Co-Authors

Mien Chie Hung
Mien Chie Hung China Medical University
Weiya Xia
Weiya Xia The University of Texas MD Anderson Cancer Center
Dihua Yu
Dihua Yu The University of Texas MD Anderson Cancer Center
Gabriel N. Hortobagyi
Gabriel N. Hortobagyi The University of Texas MD Anderson Cancer Center
Dung Fang Lee
Dung Fang Lee The University of Texas Health Science Center at Houston
Jun Yao
Jun Yao The University of Texas MD Anderson Cancer Center
Hui Kuan Lin
Hui Kuan Lin Wake Forest University
Han Liang
Han Liang The University of Texas MD Anderson Cancer Center
Huamin Wang
Huamin Wang The University of Texas MD Anderson Cancer Center
Chang Hai Tsai
Chang Hai Tsai Asian University

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