World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
17289
World Ranking
10077
National Ranking
4407

Overview

Xiao Zhen Zhou is affiliated with the Beth Israel Deaconess Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these disciplines, their work focuses notably on Molecular Biology, Oncology, Immunology, Neurology, and Cellular and Molecular Neuroscience.

The scientist's main research topics include signaling pathways in disease, peptidase inhibition and analysis, toxin mechanisms and immunotoxins, nerve injury and regeneration, neuroblastoma research and treatments, Alzheimer's disease research and treatments, and neuroinflammation and neurodegeneration mechanisms.

Recent papers authored or co-authored by Xiao Zhen Zhou reflect their involvement in cancer biology, neurodegenerative disease mechanisms, and therapeutic development. Notable publications include:

  • "Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy," 2021, Cell
  • "Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo," 2021, Nature Chemical Biology
  • "Identification of a potent and selective covalent Pin1 inhibitor," 2020, Nature Chemical Biology
  • "Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice," 2021, Science Translational Medicine
  • "Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease," 2020, Journal of Pineal Research

Xiao Zhen Zhou frequently publishes in high-impact venues such as Nature Chemical Biology, Journal of Hazardous Materials, Nature Communications, Frontiers in Cell and Developmental Biology, and Cell.

Their collaboration network includes several frequent co-authors, such as Kun Ping Lu, Kazuhiro Koikawa, Chenxi Qiu, Nathanael S. Gray, and Shin Kibe, indicating ongoing partnerships in their interdisciplinary research efforts.

Best Publications

  • Sequence-specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism

    Michael B. Yaffe;Mike Schutkowski;Minhui Shen;Xiao Zhen Zhou

  • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

    Pei Jung Lu;Gerburg Wulf;Xiao Zhen Zhou;Peter Davies

  • Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

    Pei Jung Lu;Xiao Zhen Zhou;Minhui Shen;Kun Ping Lu

  • The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

    Kun Ping Lu;Xiao Zhen Zhou

  • Regulation of Raf-1 by Direct Feedback Phosphorylation

    Michele K. Dougherty;Jürgen Müller;Daniel A. Ritt;Ming Zhou

  • Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.

    Xiao Zhen Zhou;Oliver Kops;Andreas Werner;Pei Jung Lu

  • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

    Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou

  • Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

    Yih-Cherng Liou;Anyang Sun;Anyang Sun;Akihide Ryo;Akihide Ryo;Xiao Zhen Zhou

  • The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

    Hongwu Zheng;Han You;Xiao Zhen Zhou;Stephen A. Murray

  • Pinning down proline-directed phosphorylation signaling.

    Kun Ping Lu;Yih Cherng Liou;Xiao Zhen Zhou

  • Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

    Asami Kondo;Koorosh Shahpasand;Rebekah Mannix;Jianhua Qiu

  • The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor

    Xiao Zhen Zhou;Kun Ping Lu

  • Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

    Chad A. Tagge;Andrew M. Fisher;Olga V. Minaeva;Amanda Gaudreau-Balderrama

  • Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

    Yih-Cherng Liou;Xiao Zhen Zhou;Kun Ping Lu

  • Critical Role of WW Domain Phosphorylation in Regulating Phosphoserine Binding Activity and Pin1 Function

    Pei Jung Lu;Xiao Zhen Zhou;Yih Cherng Liou;Joseph P. Noel

  • Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis

    Rukhsana Sultana;Debra Boyd-Kimball;H. Fai Poon;Jain Cai

  • The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.

    Xiao Zhen Zhou;Kun Ping Lu

  • Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.

    Masafumi Nakamura;Xiao Zhen Zhou;Kun Ping Lu

  • Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

    Kazuhiro Nakamura;Alex Greenwood;Lester Binder;Eileen H. Bigio

  • Active Pin1 is a key target of all- trans retinoic acid in acute promyelocytic leukemia and breast cancer

    Shuo Wei;Shingo Kozono;Lev Kats;Morris Nechama

Frequent Co-Authors

Kun Ping Lu
Kun Ping Lu Beth Israel Deaconess Medical Center
Gerburg M. Wulf
Gerburg M. Wulf Beth Israel Deaconess Medical Center
Nathanael S. Gray
Nathanael S. Gray Stanford University
Jarrod A. Marto
Jarrod A. Marto Harvard University
Gunter Fischer
Gunter Fischer Max Planck Society
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University
Akihide Ryo
Akihide Ryo Yokohama City University
Scott B. Ficarro
Scott B. Ficarro Harvard University
Ruey-Hwa Chen
Ruey-Hwa Chen Academia Sinica
Xiao-Jiang Li
Xiao-Jiang Li Jinan University

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Related Online Degrees & Career Pathways

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