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Ruey-Hwa Chen

Ruey-Hwa Chen

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
21738
World Ranking
14754
National Ranking
70

Overview

Ruey-Hwa Chen is affiliated with Academia Sinica in Taiwan and focuses on research primarily situated in biochemistry, genetics, and molecular biology, with additional contributions to medicine. Their scientific output includes 46 publications in biochemistry, genetics, and molecular biology, alongside 17 in medicine, reflecting a broad engagement with these disciplines.

The scientist's research spans several subfields, including molecular biology, cancer research, epidemiology, oncology, and immunology. Key topics covered by their work include ubiquitin and proteasome pathways, autophagy in disease and therapy, extracellular vesicles in disease, RNA modifications and cancer, microRNA in disease regulation, cancer-related molecular mechanisms research, and endoplasmic reticulum stress and disease.

Chen has produced several notable papers, illustrating both their research interests and collaboration network. Among these are:

  • VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism (2021, Nature Communications)
  • Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation (2020, Cell Death and Disease)
  • Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization (2021, Science Advances)
  • TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation (2023, Nature Communications)
  • Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo (2023, Advanced Materials)

Chen frequently publishes in scientific journals including Cell Death and Disease, Journal of Biomedical Science, Nature Communications, Molecular Cell, and Cancer Research. These venues indicate an emphasis on cellular and molecular mechanisms associated with disease.

Their collaborative network is marked by recurrent co-authors such as Kuen-Phon Wu, Nai Yang Yeat, Shu-Yu Lin, Ruei-Liang Yan, and Yunching Chen, reflecting ongoing scientific partnerships primarily connected to studies in molecular biology and oncology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.

    Reinhard Ebner;Ruey-Hwa Chen;Lillian Shum;Sean Lawler

  • TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase

    Chuan-Wei Jang;Chun-Hau Chen;Chun-Chieh Chen;Jia-yun Chen

  • Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities

    Ruey-Hwa Chen;Reinhard Ebner;Rik Derynck

  • Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

    Ruey-Hwa Chen;Ming-Cheng Chang;Yi-Hsien Su;Yuh-Tyng Tsai

  • miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4

    Hsin Yi Chen;Yu Min Lin;Yu Min Lin;Hsiang Ching Chung;Hsiang Ching Chung;Yaw Dong Lang

  • Determination of type I receptor specificity by the type II receptors for TGF-beta or activin

    Reinhard Ebner;Ruey-Hwa Chen;Sean Lawler;Thomas Zioncheck

  • Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.

    Chun Hau Chen;Won Jing Wang;Jean Cheng Kuo;Hsiao Chien Tsai

  • A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

    Ruey-Hwa Chen;P. J. Miettinen;E. M. Maruoka;L. Choy

  • Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway.

    Ruey-Hwa Chen;Yi-Hsien Su;Rachel Lc Chuang;Tien-Yun Chang

  • Ubiquitin-mediated regulation of autophagy

    Ruey-Hwa Chen;Ruey-Hwa Chen;Yu-Hsuan Chen;Yu-Hsuan Chen;Tzu-Yu Huang;Tzu-Yu Huang

  • Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

    Yu Ru Lee;Yu Ru Lee;Ming Chen;Ming Chen;Jonathan D. Lee;Jonathan D. Lee;Jinfang Zhang

  • A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

    Wei Chien Yuan;Yu Ru Lee;Yu Ru Lee;Shiu Feng Huang;Shiu Feng Huang;Yu Min Lin;Yu Min Lin

  • Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

    Chin Chih Liu;Chin Chih Liu;Yu Ching Lin;Yu Ching Lin;Yu Hsuan Chen;Yu Hsuan Chen;Chun Ming Chen

  • K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.

    Wei Chien Yuan;Yu Ru Lee;Shu Yu Lin;Li Ying Chang

  • Brk Activates Rac1 and Promotes Cell Migration and Invasion by Phosphorylating Paxillin

    Hsin Yi Chen;Che Hung Shen;Yuh Tyng Tsai;Feng Chi Lin

  • Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

    Tae Ho Lee;Chun-Hau Chen;Futoshi Suizu;Pengyu Huang

  • DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

    Won-Jing Wang;Jean-Cheng Kuo;Chung-Chen Jane Yao;Ruey-Hwa Chen

  • Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells.

    W. G. Mcgregor;Ruey-Hwa Chen;L. Lukash;V. M. Maher

  • Homomeric interactions between type II transforming growth factor-beta receptors.

    Ruey-Hwa Chen;R. Derynck

Frequent Co-Authors

Ming-Zong Lai
Ming-Zong Lai Academia Sinica
Veronica M. Maher
Veronica M. Maher Michigan State University
J. Justin McCormick
J. Justin McCormick Michigan State University
Rik Derynck
Rik Derynck University of California, San Francisco
Kun Ping Lu
Kun Ping Lu Beth Israel Deaconess Medical Center
Adi Kimchi
Adi Kimchi Weizmann Institute of Science
Sean E. Lawler
Sean E. Lawler Brown University
Xiao Zhen Zhou
Xiao Zhen Zhou Beth Israel Deaconess Medical Center
Mien Chie Hung
Mien Chie Hung China Medical University
Reinhard Ebner
Reinhard Ebner Human Genome Sciences (United States)

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