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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
15927
World Ranking
16947
National Ranking
6982

Overview

Reinhard Ebner is affiliated with Human Genome Sciences in the United States and contributes to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research work intersects key subfields such as Pulmonary and Respiratory Medicine, Oncology, Cancer Research, and Molecular Biology.

The main topics of their work include:

  • Prostate Cancer Treatment and Research
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • PARP inhibition in cancer therapy
  • DNA Repair Mechanisms

Reinhard Ebner has co-authored papers with multiple researchers, frequently collaborating with Miklós Dióssy, Viktória Tisza, Jia Zhou, Zsófia Sztupinszki, and Denise Young.

Their recent publications highlight investigations into prostate cancer, with particular attention to genetic alterations and their clinical implications. Notable papers include:

  • "Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression," published in 2024 in npj Precision Oncology
  • "Subclonal CHD1 deletion is more frequent in African American prostate cancers and associated with rapid disease progression and limited levels of homologous recombination deficiency," published in 2021 in bioRxiv (Cold Spring Harbor Laboratory)

These publications underscore a focus on genetic deletions related to prostate cancer progression, with attention to racial disparities and associated molecular mechanisms.

Reinhard Ebner's work has appeared primarily in venues such as npj Precision Oncology and bioRxiv (Cold Spring Harbor Laboratory), reflecting a focus on cancer genomics and precision medicine approaches. The research contributions integrate understanding of DNA repair pathways and their implications for targeted therapies like PARP inhibition.

Best Publications

  • The receptor for the cytotoxic ligand TRAIL

    Guohua Pan;Karen O'Rourke;Arul M. Chinnaiyan;Reiner Gentz

  • Spheroid-based drug screen: considerations and practical approach

    Juergen Friedrich;Claudia Seidel;Reinhard Ebner;Leoni A Kunz-Schughart

  • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

    P J Miettinen;R Ebner;A R Lopez;R Derynck

  • LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

    Davide N Mauri;Reinhard Ebner;Rebecca I Montgomery;Kristine D Kochel

  • The use of 3-D cultures for high-throughput screening: the multicellular spheroid model.

    Leoni A. Kunz-Schughart;James P. Freyer;Ferdinand Hofstaedter;Reinhard Ebner

  • A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis

    Kang-Yeol Yu;Byungsuk Kwon;Jian Ni;Yifan Zhai

  • Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.

    Reinhard Ebner;Ruey-Hwa Chen;Lillian Shum;Sean Lawler

  • Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

    Juergen Friedrich;Reinhard Ebner;Leoni A Kunz-Schughart

  • Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities

    Ruey-Hwa Chen;Reinhard Ebner;Rik Derynck

  • Determination of type I receptor specificity by the type II receptors for TGF-beta or activin

    Reinhard Ebner;Ruey-Hwa Chen;Sean Lawler;Thomas Zioncheck

  • Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

    R Ebner;R Derynck

  • A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity.

    Yanggu Shi;Stephen J. Ullrich;Jun Zhang;Kevin Connolly

  • Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy

    M Schmitz;A Temme;V Senner;R Ebner

  • A Reliable Tool to Determine Cell Viability in Complex 3-D Culture: The Acid Phosphatase Assay

    Juergen Friedrich;Wolfgang Eder;Juana Castaneda;Markus Doss

  • Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

    B A Arrick;A R Lopez;F Elfman;R Ebner

  • Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells.

    D Gazit;R Ebner;A J Kahn;R Derynck

  • Interleukins-21 and 22

    Reinhard Ebner;Steven M. Ruben

  • 186 human secreted proteins

    Steven Ruben;Craig Rosen;Daniel Soppet;Kenneth Carter

  • STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo

    Melanie Spitzner;Birte Roesler;Christian Bielfeld;Georg Emons

  • Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.

    Michael A. Rieger;Reinhard Ebner;David R. Bell;Andrea Kiessling

Frequent Co-Authors

Paul A. Moore
Paul A. Moore MacroGenics (United States)
Steven M. Ruben
Steven M. Ruben Celera Corporation
Jian Ni
Jian Ni Zhejiang Normal University
Craig A. Rosen
Craig A. Rosen CoGenesys, Inc.
Reiner L. Gentz
Reiner L. Gentz Gentz Biopharmaceutical Consulting
Rik Derynck
Rik Derynck University of California, San Francisco
Marc Schmitz
Marc Schmitz TU Dresden
Sean E. Lawler
Sean E. Lawler Brown University
Matthew L. Freedman
Matthew L. Freedman Harvard University
Thomas Ried
Thomas Ried National Institutes of Health

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