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Biology and Biochemistry

D-Index
60
Citations
16302
World Ranking
11784
National Ranking
5067

Overview

Sean E. Lawler is affiliated with Brown University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine. Within these broader fields, their work focuses on several subfields including Molecular Biology, Immunology, Genetics, Oncology, and Cancer Research.

Lawler's research centers on topics such as virus-based gene therapy, glioma diagnosis and treatment, immune cells in cancer, CAR-T cell therapy research, interferon and immune responses, cytomegalovirus and herpesvirus research, as well as cancer research and treatments.

Frequent coauthors collaborate with Lawler, including:

  • E. Antonio Chiocca
  • Michal O. Nowicki
  • Mykola Zdioruk
  • Jorge L. Jimenez-Macias
  • Philippa Vaughn-Beaucaire

Lawler has published extensively in various scientific venues. The most common publication outlets for their work include:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cancers
  • Regular and Young Investigator Award Abstracts

Among their recent publications are:

  • "STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models," 2022, Proceedings of the National Academy of Sciences
  • "Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates," 2022, Nature Biomedical Engineering
  • "Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria," 2021, The Journal of Experimental Medicine
  • "Modeling Oncolytic Viral Therapy, Immune Checkpoint Inhibition, and the Complex Dynamics of Innate and Adaptive Immunity in Glioblastoma Treatment," 2020, Frontiers in Physiology
  • "Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer," 2021, Science Advances

Best Publications

  • MicroRNAs in cancer: biomarkers, functions and therapy.

    Josie Hayes;Pier Paolo Peruzzi;Sean Lawler

  • microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

    Benjamin Kefas;Jakub Godlewski;Laurey Comeau;Yunqing Li

  • Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

    Jakub Godlewski;Michal O. Nowicki;Agnieszka Bronisz;Shanté Williams

  • Oncolytic Viruses in Cancer Treatment: A Review

    Sean E. Lawler;Maria Carmela Speranza;Choi Fong Cho;E. Antonio Chiocca

  • Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.

    Reinhard Ebner;Ruey-Hwa Chen;Lillian Shum;Sean Lawler

  • Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

    Franz L. Ricklefs;Franz L. Ricklefs;Quazim Alayo;Harald Krenzlin;Ahmad B. Mahmoud;Ahmad B. Mahmoud

  • MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.

    Jakub Godlewski;Michal O. Nowicki;Agnieszka Bronisz;Gerard Nuovo

  • Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

    Michel Goedert;Masato Hasegawa;Ross Jakes;Sean Lawler

  • Determination of type I receptor specificity by the type II receptors for TGF-beta or activin

    Reinhard Ebner;Ruey-Hwa Chen;Sean Lawler;Thomas Zioncheck

  • Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

    A. Bronisz;J. Godlewski;J. A. Wallace;A.S. Merchant

  • Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.

    Choi-Fong Cho;Choi-Fong Cho;Justin M. Wolfe;Colin M. Fadzen;David Calligaris

  • Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

    Sean Lawler;Yvonne Fleming;Michel Goedert;Philip Cohen

  • Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

    Sonja Bergmann;Sean E. Lawler;Yuan Qu;Colin M. Fadzen

  • The Neuronal MicroRNA miR-326 Acts in a Feedback Loop with Notch and Has Therapeutic Potential against Brain Tumors

    Benjamin Kefas;Laurey Comeau;Desiree H. Floyd;Oleksandr Seleverstov

  • Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity

    Mireia Guerau-de-Arellano;Kristen M. Smith;Jakub Godlewski;Yue Liu

  • The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network

    Olivier Gavet;Sylvie Ozon;Valérie Manceau;Sean Lawler

  • Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1

    Agnieszka Bronisz;Agnieszka Bronisz;Yan Wang;Michal O. Nowicki;Michal O. Nowicki;Pierpaolo Peruzzi

  • NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.

    Christopher A Alvarez-Breckenridge;Jianhua Yu;Richard Price;Jeffrey Wojton

  • The Type II Transforming Growth Factor-β Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues

    Sean Lawler;Xin-Hua Feng;Ruey-Hwa Chen;E. Miko Maruoka

  • Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

    David Calligaris;Kalvis Hornburg;E. Antonio Chiocca;Nathalie Y. R. Agar

Frequent Co-Authors

E. Antonio Chiocca
E. Antonio Chiocca Brigham and Women's Hospital
Keith L. Ligon
Keith L. Ligon Harvard University
David A. Reardon
David A. Reardon Harvard University
Gordon J. Freeman
Gordon J. Freeman Harvard University
Balveen Kaur
Balveen Kaur Augusta University
Ralph Weissleder
Ralph Weissleder Harvard University
Patrick Y. Wen
Patrick Y. Wen Harvard University
Gerard J. Nuovo
Gerard J. Nuovo The Ohio State University
Manfred Westphal
Manfred Westphal Universität Hamburg

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