World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
16591
World Ranking
9558
National Ranking
4220

Overview

Paul A. Moore is affiliated with MacroGenics in the United States and has contributed extensively to the field of medicine, with a particular focus on oncology and immunology. Their research encompasses various aspects of cancer immunotherapy, immune response mechanisms, and therapeutic antibody development.

The scientist's recent papers highlight active involvement in advanced cancer therapies and immunological treatments. Notable publications include:

  • Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer, 2020, Molecular Cancer Therapeutics
  • Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial, 2022, Journal for ImmunoTherapy of Cancer
  • The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial, 2023, Nature Medicine
  • Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain, 2020, Journal of Dental Research
  • Neoadjuvant enoblituzumab in localized prostate cancer: a single-arm, phase 2 trial, 2023, Nature Medicine

Frequent co-authors collaborating with Moore include:

  • Ezio Bonvini
  • Francine Chen
  • Sandra Gabriele
  • Gundo Diedrich
  • Anushka De Costa

Moore has published regularly in several scientific venues, with the following being prominent:

  • Cancer Research
  • The Journal of the American Dental Association
  • Regular and Young Investigator Award Abstracts
  • Journal of Dental Research
  • Journal of Clinical Oncology

The scientist's work spans several subfields of medicine. These include oncology, immunology, radiology and imaging, oral surgery, and pulmonary and respiratory medicine. Their primary research topics are centered around:

  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Dental Anxiety and Anesthesia Techniques
  • Immune Cell Function and Interaction
  • Inflammatory mediators and NSAID effects

In addition to articles, Moore has authored a book published by the University of Illinois Press titled The Sunday Paper (2022).

Best Publications

  • BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

    Paul A. Moore;Ornella Belvedere;Amy Orr;Krystyna Pieri

  • Synthesis and release of B-lymphocyte stimulator from myeloid cells

    Bernardetta Nardelli;Ornella Belvedere;Viktor Roschke;Paul A. Moore

  • TL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator

    Thi Sau Migone;Jun Zhang;Xia Luo;Li Zhuang

  • Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK) INTERACTION WITH TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTORS AND ACTIVATION OF NF-κB AND c-JUN N-TERMINAL KINASE

    Bryant G. Darnay;Valsala Haridas;Jian Ni;Paul A. Moore

  • Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

    Wei-Chun Au;Paul A. Moore;William Lowther;Yuang-Taung Juang

  • Virus-specific Activation of a Novel Interferon Regulatory Factor, IRF-5, Results in the Induction of Distinct Interferon α Genes

    Betsy J. Barnes;Paul A. Moore;Paula M. Pitha

  • Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase IDENTIFICATION OF A NOVEL TRAF6 INTERACTION MOTIF

    Bryant G. Darnay;Jian Ni;Paul A. Moore;Bharat B. Aggarwal

  • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma

    Paul A. Moore;Wenjun Zhang;G. Jonah Rainey;Steve Burke

  • Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes

    David W. LaFleur;Bernardetta Nardelli;Tatiana Tsareva;Don Mather

  • Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

    Wei-Chun Au;Paul A. Moore;David W. LaFleur;Bertrand Tombal

  • Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

    Deryk Loo;Ralph F. Alderson;Francine Z. Chen;Ling Huang

  • Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

    Susan L. Schafer;Rongtuan Lin;Paul A. Moore;John Hiscott

  • CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers

    L M Smith;A. I. Nesterova;M C Ryan;S Duniho

  • Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion.

    Syd Johnson;Stephen Burke;Ling Huang;Sergey Gorlatov

  • Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS

    Youmei Wu;Dana Bressette;Jeff A. Carrell;Thomas Kaufman

  • Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties

    Jeffrey L Nordstrom;Sergey Gorlatov;Wenjun Zhang;Yinhua Yang

  • First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors

    Yung-Jue Bang;G. Giaccone;S. A. Im;D. Y. Oh

  • Therapeutic Control of B Cell Activation via Recruitment of Fcγ Receptor IIb (CD32B) Inhibitory Function With a Novel Bispecific Antibody Scaffold

    Maria-Concetta Veri;Stephen Burke;Ling Huang;Hua Li

  • Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation.

    Yu-Ping Xia;Yanan Zhao;Jeffrey Marcus;Pablo A. Jimenez

  • Targeting CD123 in acute myeloid leukemia using a T-cell-directed dual-affinity retargeting platform.

    Muneera Al-Hussaini;Michael P. Rettig;Julie K. Ritchey;Darja Karpova

Frequent Co-Authors

Reinhard Ebner
Reinhard Ebner Human Genome Sciences (United States)
Ezio Bonvini
Ezio Bonvini Center for Biologics Evaluation and Research
Craig A. Rosen
Craig A. Rosen CoGenesys, Inc.
Steven M. Ruben
Steven M. Ruben Celera Corporation
Jian Ni
Jian Ni Zhejiang Normal University
Syd Johnson
Syd Johnson AstraZeneca (United Kingdom)
Scott Koenig
Scott Koenig MacroGenics (United States)
Reiner L. Gentz
Reiner L. Gentz Gentz Biopharmaceutical Consulting
Paula M. Pitha
Paula M. Pitha Johns Hopkins University
Jon M. Wigginton
Jon M. Wigginton Bristol-Myers Squibb (Germany)

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