Paula M. Pitha spends much of her time researching Molecular biology, Interferon regulatory factors, Interferon, Gene and Transcription factor. The study incorporates disciplines such as Promoter, Response element, Gene expression, Transactivation and Regulation of gene expression in addition to Molecular biology. Her study in Interferon regulatory factors is interdisciplinary in nature, drawing from both Signal transduction, Cell biology, Transcription and IRF1.
In her research, Chloramphenicol acetyltransferase and DNA-binding protein is intimately related to Vero cell, which falls under the overarching field of Interferon. Her work deals with themes such as Alpha interferon and Virology, which intersect with Gene. Paula M. Pitha focuses mostly in the field of Transcription factor, narrowing it down to matters related to Chemokine and, in some cases, Ligand and MAPK/ERK pathway.
Her primary areas of investigation include Interferon, Molecular biology, Virology, Gene and Interferon regulatory factors. Her Interferon research includes elements of RNA, Fibroblast, Biochemistry and Cell biology. Her Molecular biology research includes themes of Promoter, Gene expression, Transcription factor, Alpha interferon and Regulation of gene expression.
As part of one scientific family, Paula M. Pitha deals mainly with the area of Virology, narrowing it down to issues related to the Genetic enhancement, and often Viral etiology. Her Gene research integrates issues from Cell culture and Herpes simplex virus. Her research integrates issues of Response element, IRF1 and Transactivation in her study of Interferon regulatory factors.
The scientist’s investigation covers issues in Immunology, Interferon regulatory factors, Virology, Interferon and Transcription factor. Her Immune system and Tumor necrosis factor alpha study in the realm of Immunology interacts with subjects such as Leishmania donovani. Her Interferon regulatory factors research is multidisciplinary, incorporating elements of Cancer research, Antigen, Molecular biology, IRF1 and Primary effusion lymphoma.
Her Molecular biology research incorporates themes from Promoter, TLR3 and PRDM1. Her work carried out in the field of Virology brings together such families of science as Innate immune system and Downregulation and upregulation. Paula M. Pitha combines subjects such as Type I interferon production, TLR7, Gene and IRF3 with her study of Interferon.
Her scientific interests lie mostly in Interferon regulatory factors, Interferon, Ubiquitin, Molecular biology and ISG15. Her biological study spans a wide range of topics, including Signal transduction and TLR3. Her studies in Interferon integrate themes in fields like Cancer research, Transcription factor and Proteasome.
Her research ties Gene isoform and Molecular biology together. The ISG15 study which covers Innate immune system that intersects with Virology, Mononegavirales, Filoviridae, RNA and RNA virus. In her study, which falls under the umbrella issue of Gene, Virus is strongly linked to Cell culture.
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LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Katherine A. Fitzgerald;Daniel C. Rowe;Betsy J. Barnes;Daniel R. Caffrey.
Journal of Experimental Medicine (2003)
E-Cadherin Expression Is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas
Jeremy R. Graff;James G. Herman;Rena G. Lapidus;Hemi Chopra.
Cancer Research (1995)
Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation
Rongtuan Lin;Christophe Heylbroeck;Paula M. Pitha;John Hiscott.
Molecular and Cellular Biology (1998)
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7
Jongdae Lee;Tsung-Hsien Chuang;Vanessa Redecke;Liping She.
Proceedings of the National Academy of Sciences of the United States of America (2003)
The growing family of interferon regulatory factors
Hannah Nguyen;John Hiscott;Paula M. Pitha.
Cytokine & Growth Factor Reviews (1997)
Cutting Edge: Activation of Toll-Like Receptor 2 Induces a Th2 Immune Response and Promotes Experimental Asthma
Vanessa Redecke;Hans Häcker;Sandip K. Datta;Agnes Fermin.
Journal of Immunology (2004)
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Wei-Chun Au;Paul A. Moore;William Lowther;Yuang-Taung Juang.
Proceedings of the National Academy of Sciences of the United States of America (1995)
The Interferon Regulatory Factor, IRF5, Is a Central Mediator of Toll-like Receptor 7 Signaling
Annett Schoenemeyer;Betsy J. Barnes;Margo.E. Mancl;Eicke Latz.
Journal of Biological Chemistry (2005)
Virus-specific Activation of a Novel Interferon Regulatory Factor, IRF-5, Results in the Induction of Distinct Interferon α Genes
Betsy J. Barnes;Paul A. Moore;Paula M. Pitha.
Journal of Biological Chemistry (2001)
On the Role of IRF in Host Defense
Betsy Barnes;Barbora Lubyova;Paula M. Pitha.
Journal of Interferon and Cytokine Research (2002)
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