World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
100
Citations
29738
World Ranking
422
National Ranking
193

Medicine

D-Index
100
Citations
30351
World Ranking
8360
National Ranking
4320

Overview

Alan N. Houghton is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions to medicine. Within these fields, they specialize in immunology and oncology.

The main topics in their research include:

  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • CAR-T Cell Therapy Research
  • Immune Cells in Cancer
  • Immune Cell Function and Interaction

Alan N. Houghton has contributed to several recent papers, reflecting their work in immunotherapy and cancer research. Selected publications include:

  • "Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness," 2021, JCI Insight
  • "Abstract 4167: Combination of cyclophosphamide with immune checkpoint blockade inhibition elicits potent tumor control in a preclinical melanoma model," 2022, Cancer Research
  • "791 Immune checkpoint blockade enhances cyclophosphamide induced anti-tumor immunity in a preclinical melanoma model," 2022, Regular and Young Investigator Award Abstracts
  • "789 Immune checkpoint blockade augments cyclophosphamide induced anti-tumor immunity by expanding effector CD8+T cell clones in a preclinical melanoma model," 2023, Regular and Young Investigator Award Abstracts
  • "869-P: OGAP-Diabetes-Proteomics-Based Target Discovery Platform for Type 2 Diabetes," 2025, Diabetes

The scientist's frequent coauthors include:

  • Daniel Hirschhorn
  • Allison Betof Warner
  • Taha Merghoub
  • Jedd D. Wolchok
  • Linda Hamadene

Their research appears in multiple venues, with notable contributions in:

  • Regular and Young Investigator Award Abstracts
  • JCI Insight
  • Cancer Research
  • Diabetes

Best Publications

  • Generation of human monoclonal antibodies reactive with cellular antigens

    Richard J. Cote;Donna M. Morrissey;Alan N. Houghton;Edward J. Beattie

  • Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

    Alan N. Houghton;David Mintzer;Carlos Cordon-Cardo;Sydney Welt

  • Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.

    Mary Jo Turk;José A. Guevara-Patiño;Gabrielle A. Rizzuto;Manuel E. Engelhorn

  • Fc receptors are required in passive and active immunity to melanoma

    Raphael Clynes;Yoshizumi Takechi;Yoichi Moroi;Alan Houghton

  • Diagnosis and Treatment of Early Melanoma: NIH Consensus Development Panel on Early Melanoma

    Lowell A. Goldsmith;Frederic B. Askin;Alfred E. Chang;Cynthia Cohen

  • Cancer antigens: immune recognition of self and altered self.

    A N Houghton

  • Focus on melanoma

    Alan N Houghton;David Polsky

  • Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

    Flora Castellino;Philip E. Boucher;Katrin Eichelberg;Mark Mayhew

  • An Evidence‐based Staging System for Cutaneous Melanoma

    Charles M. Balch;Seng Jaw Soong;Michael B. Atkins;Antonio C. Buzaid

  • A new American Joint Committee on Cancer staging system for cutaneous melanoma.

    Charles M. Balch;Antonio C. Buzaid;Michael B. Atkins;Natale Cascinelli

  • Homozygous deletions within human chromosome band 9p21 in melanoma.

    J W Fountain;M Karayiorgou;M S Ernstoff;J M Kirkwood

  • Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

    A N Houghton;M Eisinger;A P Albino;J G Cairncross

  • Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.

    Philip J. Bergman;Joanne McKnight;Andrew Novosad;Sarah Charney

  • Monocytic CCR2+ Myeloid Derived Suppressor Cells Promote Immune Escape By Limiting Activated CD8 T Cell Infiltration Into The Tumor Microenvironment

    Alexander M. Lesokhin;Tobias M. Hohl;Shigehisa Kitano;Czrina Cortez

  • Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center.

    P.J. Bergman;M.A. Camps-Palau;J.A. McKnight;N.F. Leibman

  • Immunity against cancer: lessons learned from melanoma.

    Alan N Houghton;Jason S Gold;Nathalie E Blachere

  • The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.

    Setaluri Vijayasaradhi;B. Bouchard;A. N. Houghton

  • Tumor immunity and autoimmunity induced by immunization with homologous DNA.

    Lawrence W. Weber;Wilbur B. Bowne;Jedd D. Wolchok;Roopa Srinivasan

  • OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

    Daniel Hirschhorn-Cymerman;Gabrielle A. Rizzuto;Taha Merghoub;Adam D. Cohen

  • Analysis of BRAF and N-RAS Mutations in Metastatic Melanoma Tissues

    Alexis Gorden;Iman Osman;Weiming Gai;Dan He

  • GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

    Stephanie J. Muriglan;Teresa Ramirez-Montagut;Onder Alpdogan;Thomas W. van Huystee

  • Monoclonal antibody therapy for cancer.

    Lovett Dr;Scheinberg Da;Houghton An

Frequent Co-Authors

Jedd D. Wolchok
Jedd D. Wolchok Cornell University
Taha Merghoub
Taha Merghoub Cornell University
Paul B. Chapman
Paul B. Chapman Memorial Sloan Kettering Cancer Center
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Herbert F. Oettgen
Herbert F. Oettgen Memorial Sloan Kettering Cancer Center
Philip O. Livingston
Philip O. Livingston Memorial Sloan Kettering Cancer Center
Miguel-Angel Perales
Miguel-Angel Perales Memorial Sloan Kettering Cancer Center
Richard J. Cote
Richard J. Cote Washington University in St. Louis
Katherine S. Panageas
Katherine S. Panageas Memorial Sloan Kettering Cancer Center
Daniel G. Coit
Daniel G. Coit Memorial Sloan Kettering Cancer Center

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