His scientific interests lie mostly in Melanoma, Internal medicine, Surgery, Vemurafenib and Oncology. His Melanoma research is multidisciplinary, incorporating perspectives in V600E, Ipilimumab and Metastasis. His study focuses on the intersection of Metastasis and fields such as Immunology with connections in the field of Haematopoiesis and Microvesicles.
His study brings together the fields of Gastroenterology and Internal medicine. In the subject of general Surgery, his work in Clinical endpoint is often linked to Stage IIIC, thereby combining diverse domains of study. His Oncology research incorporates elements of Median survival, Randomization and Pathology.
The scientist’s investigation covers issues in Melanoma, Internal medicine, Oncology, Cancer research and Immunology. His primary area of study in Melanoma is in the field of Vemurafenib. His Vemurafenib study integrates concerns from other disciplines, such as Dermatology, V600E and Overall survival.
His studies in Internal medicine integrate themes in fields like Gastroenterology and Surgery. Paul B. Chapman has included themes like Metastatic melanoma, Advanced melanoma, Clinical trial, Dabrafenib and Disease in his Oncology study. His Cancer research research is multidisciplinary, incorporating perspectives in Mutation, MEK inhibitor, Kinase, MAPK/ERK pathway and Neuroblastoma RAS viral oncogene homolog.
His primary areas of investigation include Internal medicine, Oncology, Melanoma, Ipilimumab and Nivolumab. His studies link Surgery with Internal medicine. His Oncology research includes themes of Cancer treatment, Cancer, Advanced melanoma, Clinical trial and Vemurafenib.
The concepts of his Vemurafenib study are interwoven with issues in Clinical endpoint and Survival analysis. His Melanoma study contributes to a more complete understanding of Cancer research. His studies examine the connections between Cancer research and genetics, as well as such issues in Neuroblastoma RAS viral oncogene homolog, with regards to Kinase.
Paul B. Chapman mostly deals with Internal medicine, Melanoma, Oncology, Ipilimumab and In patient. His Hazard ratio, Pembrolizumab, Cohort and Adverse effect study in the realm of Internal medicine connects with subjects such as MEDLINE. His Hazard ratio research is multidisciplinary, incorporating elements of Vemurafenib and Dacarbazine.
In his study, he carries out multidisciplinary Melanoma and Erdheim–Chester disease research. His Oncology research integrates issues from Trametinib, Proportional hazards model and Retrospective cohort study. His research investigates the connection with Ipilimumab and areas like Nivolumab which intersect with concerns in Common Terminology Criteria for Adverse Events, Clinical trial and Surgery.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Paul B. Chapman;Axel Hauschild;Caroline Robert;John B. Haanen.
The New England Journal of Medicine (2011)
Inhibition of mutated, activated BRAF in metastatic melanoma.
Keith T. Flaherty;Igor Puzanov;Kevin B. Kim;Antoni Ribas.
The New England Journal of Medicine (2010)
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
Axel Hauschild;Jean Jacques Grob;Lev V. Demidov;Thomas Jouary.
The Lancet (2012)
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado;Maša Alečković;Simon Lavotshkin;Irina Matei.
Nature Medicine (2012)
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
Gideon Bollag;Peter Hirth;James Tsai;Jiazhong Zhang.
Nature (2010)
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
Ravid Straussman;Teppei Morikawa;Kevin Shee;Michal Barzily-Rokni.
Nature (2012)
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Poulikos I. Poulikakos;Yogindra Persaud;Manickam Janakiraman;Xiangju Kong.
Nature (2011)
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
Fei Su;Amaya Viros;Carla Milagre;Kerstin Trunzer.
The New England Journal of Medicine (2012)
Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study
Grant A McArthur;Paul B Chapman;Caroline Robert;James Larkin.
Lancet Oncology (2014)
Phase III Multicenter Randomized Trial of the Dartmouth Regimen Versus Dacarbazine in Patients With Metastatic Melanoma
Paul B. Chapman;Lawrence H. Einhorn;Michael L. Meyers;Scott Saxman.
Journal of Clinical Oncology (1999)
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