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Biology and Biochemistry

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Overview

Gary S. Hayward is affiliated with Johns Hopkins University in the United States. Their research spans multiple fields with a focus on medicine and agricultural and biological sciences. The scientist's work covers several subfields, including epidemiology, ecology, evolution, behavior and systematics, infectious diseases, agronomy and crop science, and oncology.

The main topics of their research include herpesvirus infections and treatments, vector-borne animal diseases, cytomegalovirus and herpesvirus research, animal disease management and epidemiology, cutaneous melanoma detection and management, melanoma and MAPK pathways, and viral infections and vectors.

Hayward has published research in various venues with notable frequent publications in bioRxiv (Cold Spring Harbor Laboratory), Journal of Zoo and Wildlife Medicine, and Pathology. Specific recent papers include:

  • IDENTIFICATION OF TWO LETHAL CASES OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS HEMORRHAGIC DISEASE IN SUMATRAN ELEPHANT CALVES IN INDONESIA (2021) in Journal of Zoo and Wildlife Medicine
  • 13. Metastatic melanoma with divergent differentiation: PCR and comparative genomic hybridization in three cases (2020) in Pathology
  • Epidemiological, Serological, and Virological Analysis of an Outbreak of Elephant Hemorrhagic Disease in Switzerland (2024) in bioRxiv (Cold Spring Harbor Laboratory)
  • Quiescent Infections of Elephant Endotheliotropic Herpesviruses and Elephant Gammaherpesviruses Detected in African Elephants in Botswana, Gabon, Kenya, South Africa and USA (2024) in bioRxiv (Cold Spring Harbor Laboratory)
  • DISC1-PML protein interaction for congenital CMV infection-induced cortical neural progenitor deficit: perturbance of host signaling via viral IE1 (2025) in bioRxiv (Cold Spring Harbor Laboratory)

Frequent coauthors collaborating with Hayward include Christopher Stremme, Adin Priadi, Arun Zachariah, MT Duffy, and Anand Mahadevan.

Best Publications

  • The order Herpesvirales.

    Andrew J. Davison;Richard Eberle;Bernhard Ehlers;Gary S. Hayward

  • Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region

    Dan R. Rawlins;Gregory Milman;S.Diane Hayward;Gary S. Hayward

  • A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

    Emily H.Y. Cheng;John Nicholas;David S. Bellows;Gary S. Hayward

  • Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6

    John Nicholas;Vivian R. Ruvolo;William H. Burns;William H. Burns;Gordon Sandford;Gordon Sandford

  • The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.

    Andrew J. Davison;Aidan Dolan;Parvis Akter;Clare Addison

  • Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters.

    P O'Hare;G S Hayward

  • Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components.

    G S Hayward;R J Jacob;S C Wadsworth;B Roizman

  • A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency

    Masahiro Fujimuro;Frederick Y Wu;Colette ApRhys;Henry Kajumbula

  • Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation.

    P O'Hare;G S Hayward

  • High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations.

    Jian Chao Zong;Dolores M. Ciufo;Donald J. Alcendor;Xiaoyu Wan

  • The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation.

    Yanxing Yu;Shizhen Emily Wang;Gary S. Hayward

  • The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.

    Jin Hyun Ahn;Gary S. Hayward

  • Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1.

    J. D. Mosca;D. P. Bednarik;N. B. K. Raj;C. A. Rosen

  • trans-acting requirements for replication of Epstein-Barr virus ori-Lyt.

    E D Fixman;G S Hayward;S D Hayward

  • Comparison of Genetic Variability at Multiple Loci across the Genomes of the Major Subtypes of Kaposi’s Sarcoma-Associated Herpesvirus Reveals Evidence for Recombination and for Two Distinct Types of Open Reading Frame K15 Alleles at the Right-Hand End

    Lynn J. Poole;Jian Chao Zong;Dolores M. Ciufo;Donald J. Alcendor

  • The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions.

    P M Lieberman;J M Hardwick;J Sample;G S Hayward

  • trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus.

    M C Pizzorno;P O'Hare;L Sha;R L LaFemina

  • Functional domains of Epstein-Barr virus nuclear antigen EBNA-1.

    R F Ambinder;M A Mullen;Y N Chang;G S Hayward

  • Homology between mammalian cell DNA sequences and human herpesvirus genomes detected by a hybridization procedure with high-complexity probe

    Keith Peden;Phoebe Mounts;Gary S. Hayward

  • The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

    Yanxing Yu;Gary S. Hayward

Frequent Co-Authors

Richard F. Ambinder
Richard F. Ambinder Johns Hopkins University
S. Diane Hayward
S. Diane Hayward Johns Hopkins University
Marvin S. Reitz
Marvin S. Reitz University of Maryland, Baltimore
Paula M. Pitha
Paula M. Pitha Johns Hopkins University
Heng Zhu
Heng Zhu Johns Hopkins University School of Medicine
Barry J. Byrne
Barry J. Byrne University of Florida
Peter O'Hare
Peter O'Hare Imperial College London
Paul M. Lieberman
Paul M. Lieberman The Wistar Institute
Nicholas Muzyczka
Nicholas Muzyczka University of Florida
Andrew J. Davison
Andrew J. Davison University of Glasgow

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