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Molecular Biology

D-Index
96
Citations
33859
World Ranking
612
National Ranking
336

Medicine

D-Index
99
Citations
34929
World Ranking
8618
National Ranking
4444

Research.com Recognitions

  • 2016 - Fellow, National Academy of Inventors

Overview

Nicholas Muzyczka is affiliated with the University of Florida in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with additional contributions in medicine. Their work intersects several subfields, including genetics, molecular biology, infectious diseases, ecology, and animal science and zoology.

The scientist's research topics largely revolve around virus-based gene therapy research, viral gastroenteritis research and epidemiology, viral infectious diseases and gene expression in insects, RNA interference and gene delivery, CRISPR and genetic engineering, bacteriophages and microbial interactions, and bacterial genetics and biotechnology.

Frequent publication venues for their work include:

  • UNC Libraries
  • Journal of Virology

Their recent papers include:

  • Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants, 2023, Journal of Virology
  • Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo, 2020, UNC Libraries
  • Charge-to-Alanine Mutagenesis of the Adeno-Associated Virus Type 2 Rep78/68 Proteins Yields Temperature-Sensitive and Magnesium-Dependent Variants, 2020, UNC Libraries
  • Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?, 2020, UNC Libraries

Frequent co-authors collaborating with Nicholas Muzyczka are:

  • R. Jude Samulski
  • Arun Srivastava
  • Antonette Bennett
  • Joseph Gargas
  • Austin Kansol

Recognition of their contributions includes being named a Fellow of the National Academy of Inventors in 2016.

Best Publications

  • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

    S Zolotukhin;B J Byrne;E Mason;I Zolotukhin

  • Site-specific integration by adeno-associated virus

    R M Linden;P Ward;C Giraud;E Winocour

  • Use of adeno-associated virus as a general transduction vector for mammalian cells.

    Muzyczka N

  • AAV transduction vectors

    Nicholas Muzyczka;Paul L. Hermonat;Kenneth I. Berns;Richard J. Samulski

  • Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.

    Corinna Burger;Oleg S. Gorbatyuk;Margaret J. Velardo;Carmen S. Peden

  • Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

    Deniz Kirik;Carl Rosenblad;Corinna Burger;Cecilia Lundberg

  • A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells.

    Sergei Zolotukhin;Mark Potter;William W. Hauswirth;John Guy

  • Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells

    Paul L. Hermonat;Nicholas Muzyczka

  • Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.

    Li Zhong;Baozheng Li;Cathryn S. Mah;Lakshmanan Govindasamy

  • Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells

    Richard J. Samulski;Kenneth I. Berns;Ming Tan;Nicholas Muzyczka

  • The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity

    Dong-Soo Im;Nicholas Muzyczka

  • Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.

    Sergei Zolotukhin;Mark Potter;Irene Zolotukhin;Yoshihisa Sakai

  • Adeno-associated virus general transduction vectors: analysis of proviral structures.

    S K McLaughlin;P Collis;P L Hermonat;N Muzyczka

  • AAV-Mediated Gene Therapy for Research and Therapeutic Purposes.

    R Jude Samulski;Nicholas Muzyczka

  • Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism

    Pei Wu;Wu Xiao;Thomas Conlon;Jeffrey Hughes

  • Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

    J G Flannery;S Zolotukhin;M I Vaquero;M M LaVail

  • Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants.

    P L Hermonat;M A Labow;R Wright;K I Berns

  • Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.

    Deniz Kirik;Lucy E. Annett;Corinna Burger;Nicholas Muzyczka

  • Studies on the Biochemical Basis of Spontaneous Mutation I. A COMPARISON OF THE DEOXYRIBONUCLEIC ACID POLYMERASES OF MUTATOR, ANTIMUTATOR, AND WILD TYPE STRAINS OF BACTERIOPHAGE T4

    Nicholas Muzyczka;Ronald L. Poland;Maurice J. Bessman

  • Identification of Amino Acid Residues in the Capsid Proteins of Adeno-Associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding

    Shaun R. Opie;Kenneth H. Warrington;Mavis Agbandje-McKenna;Sergei Zolotukhin

Frequent Co-Authors

Sergei Zolotukhin
Sergei Zolotukhin University of Florida
Ronald J. Mandel
Ronald J. Mandel University of Florida
Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida
William W. Hauswirth
William W. Hauswirth University of Florida
Barry J. Byrne
Barry J. Byrne University of Florida
Robert McKenna
Robert McKenna University of Florida
Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Arun Srivastava
Arun Srivastava University of Florida
Richard J. Samulski
Richard J. Samulski University of North Carolina at Chapel Hill
Kenneth I. Berns
Kenneth I. Berns University of Florida

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