Deniz Kirik

Research.com Recognitions

• The Science Academy Society of Turkey - Bilim Akademisi Neuroscience
• The Science Academy Society of Turkey - Bilim Akademisi Neuroscience

Overview

Best Publications

• Neuronal replacement from endogenous precursors in the adult brain after stroke

  Andreas Arvidsson;Tove Collin;Deniz Kirik;Zaal Kokaia

  3653
  Citations

• Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

  Deniz Kirik;Carl Rosenblad;Corinna Burger;Cecilia Lundberg

  868
  Citations

• Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

  M. Lundblad;M. Andersson;C. Winkler;C. Winkler;D. Kirik

  805
  Citations

• Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat

  Deniz Kirik;Carl Rosenblad;Anders Björklund

  786
  Citations

• Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.

  Manolo Carta;Thomas Carlsson;Deniz Kirik;Anders Björklund

  723
  Citations

• Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

  Deniz Kirik;Carl Rosenblad;Anders Björklund;Ronald J. Mandel

  629
  Citations

• Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model.

  Anders Björklund;Deniz Kirik;C Rosenblad;B Georgievska

  506
  Citations

• L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function.

  Christian Winkler;Christian Winkler;Deniz Kirik;Anders Björklund;M.Angela Cenci

  488
  Citations

• Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.

  Deniz Kirik;Lucy E. Annett;Corinna Burger;Nicholas Muzyczka

  475
  Citations

• Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

  Brian A. Horger;Merry C. Nishimura;Mark P. Armanini;Li-Chong Wang

  412
  Citations

• Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle

  Carl Rosenblad;Deniz Kirik;Brigitte Devaux;Barbara Moffat

  375
  Citations

• Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease

  Andisheh Eslamboli;Biljana Georgievska;Rosalind M. Ridley;Harry F. Baker

  349
  Citations

• Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

  Hélène Hall;Stefanie Reyes;Natalie Landeck;Chris Bye

  346
  Citations

• Localized striatal delivery of GDNF as a treatment for Parkinson disease

  Deniz Kirik;Biljana Georgievska;Anders Björklund

  338
  Citations

• Aberrant Sprouting and Downregulation of Tyrosine Hydroxylase in Lesioned Nigrostriatal Dopamine Neurons Induced by Long-Lasting Overexpression of Glial Cell Line Derived Neurotrophic Factor in the Striatum by Lentiviral Gene Transfer

  Biljana Georgievska;Deniz Kirik;Anders Björklund

  332
  Citations

• Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease.

  Anders Björklund;Carl Rosenblad;Christian Winkler;Deniz Kirik

  332
  Citations

• Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.

  Lachlan Thompson;Perrine Barraud;Elin Andersson;Deniz Kirik

  325
  Citations

• Cell transplantation in Parkinson's disease: how can we make it work?

  Christian Winkler;Deniz Kirik;Anders Björklund

  314
  Citations

• Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.

  Vanesa Sanchez-Guajardo;Fabia Febbraro;Deniz Kirik;Marina Romero-Ramos;Marina Romero-Ramos

  290
  Citations

• α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

  Isabel Lastres-Becker;Ayse Ulusoy;Ayse Ulusoy;Nadia G. Innamorato;Gurdal Sahin

  287
  Citations

• Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.

  Ana Muñoz;Qin Li;Fabrizio Gardoni;Elena Marcello

  284
  Citations