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61
Citations
12665
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1910
National Ranking
947

Overview

Alfred S. Lewin is affiliated with the University of Florida in the United States and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans several subfields including Molecular Biology, Ophthalmology, Cellular and Molecular Neuroscience, Immunology, and Oncology.

The main topics of their work focus on retinal health and disease, encompassing areas such as Retinal Development and Disorders, Retinal Diseases and Treatments, Photoreceptor and Optogenetics Research, and Ocular Diseases including Behçet's Syndrome. Additionally, their research covers interferon and immune responses, Cytokine Signaling Pathways and Interactions, and Glaucoma and retinal disorders.

Lewin's publication record includes a number of significant papers that show the scope of their research interests and collaborations. Notable papers include:

  • SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19, 2020, Frontiers in Immunology
  • Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium, 2021, Antioxidants
  • Automated segmentation and analysis of retinal microglia within ImageJ, 2020, Experimental Eye Research
  • Gene Therapy for Rhodopsin-associated Autosomal Dominant Retinitis Pigmentosa, 2021, International Ophthalmology Clinics
  • Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa, 2020, Scientific Reports

Frequent coauthors who have collaborated with Lewin include Cristhian J. Ildefonso, Chulbul M. Ahmed, Michael T. Massengill, Howard M. Johnson, and Anil Patel.

Their work has been published in various academic venues, with repeated contributions to:

  • Harvard Dataverse
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antioxidants
  • Scientific Reports

Through these varied publication outlets and collaborative partnerships, Alfred S. Lewin's research has addressed key areas within immunology, molecular biology, and ocular disease treatment. Their cross-disciplinary approach is reflected in the integration of molecular and cellular neuroscience with immunological and genetic perspectives on retinal conditions.

Best Publications

  • Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.

    Alfred S. Lewin;Kimberly A. Drenser;William W. Hauswirth;Shimpei Nishikawa

  • High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

    Hilda Petrs-Silva;Astra Dinculescu;Qiuhong Li;Seok-Hong Min

  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.

    Sayak K Mitter;Chunjuan Song;Xiaoping Qi;Haoyu Mao

  • Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.

    Edgardo Rodriguez-Lebron;Eileen M. Denovan-Wright;Kevin Nash;Alfred S. Lewin

  • A comprehensive review of retinal gene therapy.

    Shannon E Boye;Sanford L Boye;Alfred S Lewin;William W Hauswirth

  • Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy

    John Guy;Xiaoping Qi;Francesco Pallotti;Eric A. Schon

  • Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

    William A. Beltran;Artur V. Cideciyan;Alfred S. Lewin;Simone Iwabe

  • Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

    Marina. S. Gorbatyuk;Tessa Knox;Matthew M. LaVail;Oleg S. Gorbatyuk

  • Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina

    Hilda Petrs-Silva;Astra Dinculescu;Qiuhong Li;Wen-Tao Deng

  • Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Long-term survival and late-stage therapy

    Matthew M. LaVail;Douglas Yasumura;Michael T. Matthes;Kimberly A. Drenser

  • SOD2 knockdown mouse model of early AMD

    Verline Justilien;Ji-Jing Pang;Kutralanathan Renganathan;Xianquan Zhan

  • In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

    Oleg S Gorbatyuk;Shoudong Li;Kevin Nash;Marina Gorbatyuk

  • Production and purification of recombinant adeno-associated virus

    William W. Hauswirth;Alfred S. Lewin;Sergei Zolotukhin;Nicholas Muzyczka

  • Ribozyme gene therapy: applications for molecular medicine

    Alfred S Lewin;William W Hauswirth

  • Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

    Emily E. Brown;Alexander J. DeWeerd;Cristhian J. Ildefonso;Alfred S. Lewin

  • Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

    Marina S Gorbatyuk;Arseniy Shabashvili;Weijun Chen;Craig Meyers

  • ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy

    Amrisha Verma;Zhiying Shan;Bo Lei;Lihui Yuan

  • Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model

    Hong Yu;Rajeshwari D. Koilkonda;Tsung Han Chou;Vittorio Porciatti

  • Selective autophagy of peroxisomes in methylotrophic yeasts.

    Tuttle Dl;Lewin As;Dunn Wa

  • Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis.

    Xiaoping Qi;Alfred S. Lewin;Liang Sun;William W. Hauswirth

Frequent Co-Authors

William W. Hauswirth
William W. Hauswirth University of Florida
Gregory S. Schultz
Gregory S. Schultz University of Florida
Sanford L. Boye
Sanford L. Boye University of Florida
Gustavo D. Aguirre
Gustavo D. Aguirre University of Pennsylvania
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
Artur V. Cideciyan
Artur V. Cideciyan University of Pennsylvania
Maria B. Grant
Maria B. Grant University of Alabama at Birmingham
Matthew M. LaVail
Matthew M. LaVail University of California, San Francisco
Michael E. Boulton
Michael E. Boulton University of Alabama at Birmingham
Ronald J. Mandel
Ronald J. Mandel University of Florida

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