What is he best known for?
The fields of study he is best known for:
His main research concerns Retina, Retinal degeneration, Retinal, Cell biology and Retinal pigment epithelium.
His study in Retina is interdisciplinary in nature, drawing from both Neurotrophic factors, Ciliary neurotrophic factor, Basic fibroblast growth factor and Anatomy.
His research integrates issues of Photoreceptor cell, Rhodopsin, Genetic enhancement and Retinitis pigmentosa in his study of Retinal degeneration.
His Rhodopsin study combines topics in areas such as Molecular biology and Visual phototransduction.
His study in the field of Erg and Electroretinography is also linked to topics like Adeno-associated virus.
In his research on the topic of Cell biology, Regulator, Transgene, Cell culture, Opsin and Signal transduction is strongly related with Apoptosis.
His most cited work include:
- IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response (1030 citations)
- Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat (745 citations)
- Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor (665 citations)
What are the main themes of his work throughout his whole career to date?
Matthew M. LaVail mostly deals with Retinal degeneration, Cell biology, Retina, Retinal and Molecular biology.
His Retinal degeneration research integrates issues from Electroretinography, Degeneration, Retinitis pigmentosa, Photoreceptor cell and Rhodopsin.
His work in Cell biology covers topics such as Ciliary neurotrophic factor which are related to areas like Basic fibroblast growth factor and Glial fibrillary acidic protein.
The Retina study which covers Neurotrophic factors that intersects with Endocrinology.
His Retinal research is multidisciplinary, relying on both Genetic enhancement and Pathology.
His studies deal with areas such as Gene expression and Transgene as well as Molecular biology.
He most often published in these fields:
- Retinal degeneration (46.05%)
- Cell biology (38.14%)
- Retina (36.74%)
What were the highlights of his more recent work (between 2010-2019)?
- Retinal degeneration (46.05%)
- Cell biology (38.14%)
- Retinal (33.95%)
In recent papers he was focusing on the following fields of study:
His main research concerns Retinal degeneration, Cell biology, Retinal, Rhodopsin and Retinitis pigmentosa.
Retina and Genetics are the two main areas of interest in his Retinal degeneration studies.
His research on Retina focuses in particular on Disc shedding.
His Cell biology study integrates concerns from other disciplines, such as Apoptosis, Ceramide and Programmed cell death.
His studies examine the connections between Retinal and genetics, as well as such issues in Neuroscience, with regards to Internal medicine, Endocrinology and Regeneration.
His study in Rhodopsin is interdisciplinary in nature, drawing from both Mutant, Endoplasmic-reticulum-associated protein degradation, Photoreceptor cell, Transgenic Rats and Degenerative disease.
Between 2010 and 2019, his most popular works were:
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice (176 citations)
- Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial (130 citations)
- Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response (70 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Retinal, Retinal degeneration, Cell biology, Retinitis pigmentosa and Molecular biology.
Retinal is closely attributed to Retina in his research.
His work in the fields of Retinal pigment epithelium overlaps with other areas such as C-Mer Tyrosine Kinase.
His work in Retinal degeneration addresses issues such as Rhodopsin, which are connected to fields such as Photoreceptor cell, Degenerative Disorder and Tissue Degeneration.
In his study, which falls under the umbrella issue of Cell biology, Protein kinase B, Sirolimus, PI3K/AKT/mTOR pathway and Cancer research is strongly linked to Programmed cell death.
His Molecular biology research is multidisciplinary, incorporating elements of Gene expression and Outer nuclear layer.
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