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Biology and Biochemistry

D-Index
70
Citations
17609
World Ranking
7003
National Ranking
3223

Overview

Dean Bok is a researcher affiliated with the University of California, Los Angeles in the United States. Their work spans several fields within biochemistry, genetics, molecular biology, and medicine, with a particular focus on retinal development and disorders, immune responses, and gene therapy.

The main fields of study associated with Dean Bok include Biochemistry, Genetics and Molecular Biology, which accounts for the majority of their publications, as well as Medicine. Their subfields of study cover Molecular Biology, Immunology, Genetics, Cell Biology, and Biochemistry.

Their research topics address several key areas: retinal development and disorders, interferon and immune responses, virus-based gene therapy research, retinoids in leukemia and cellular processes, biotin and related studies, antioxidant activity and oxidative stress, and retinal diseases and treatments.

Frequently publishing in several scientific venues, Dean Bok has contributed to Nature Communications, Proceedings of the National Academy of Sciences, Redox Biology, bioRxiv (Cold Spring Harbor Laboratory), and Experimental Eye Research. Each of these venues houses at least one publication from their body of work.

Dean Bok has collaborated often with several coauthors, including Kun Do Rhee, Johanna ten Hoeve, Linsey Stiles, Thao T.T. Nguyen, and Laurent Vergnes. These frequent collaborators have contributed to advancing the research projects documented in their publications.

The following recent papers illustrate Dean Bok's research outputs:

  • Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas, 2022, Nature Communications
  • Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport, 2020, Proceedings of the National Academy of Sciences
  • Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes, 2020, Redox Biology
  • Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • In Memoriam: David S. Papermaster (1937-2024), 2024, Experimental Eye Research

Best Publications

  • Rpe65 is necessary for production of 11- cis-vitamin A in the retinal visual cycle

    T. Michael Redmond;Shirley Yu;Eric Lee;Dean Bok

  • A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A

    Riki Kawaguchi;Jiamei Yu;Jane Honda;Jane Hu

  • The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

    Don H. Anderson;Monte J. Radeke;Natasha B. Gallo;Ethan A. Chapin

  • THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RAT

    Dean Bok;Michael O. Hall

  • The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein.

    Gabriel H. Travis;J.Gregor Sutcliffe;Dean Bok

  • GABA-ergic pathways in the goldfish retina.

    Robert E. Marc;William K. Stell;Dean Bok;Dominic M. K. Lam

  • mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

    Chen Zhao;Douglas Yasumura;Xiyan Li;Michael Matthes

  • Molecular and Biochemical Characterization of Lecithin Retinol Acyltransferase

    Alberto Ruiz;Anette Winston;Young Hee Lim;Bryant A. Gilbert

  • EXPRESSION, SECRETION, AND AGE-RELATED DOWNREGULATION OF PIGMENT EPITHELIUM-DERIVED FACTOR, A SERPIN WITH NEUROTROPHIC ACTIVITY

    Joyce Tombran-Tink;Sunil M. Shivaram;Gerald J. Chader;Lincoln V. Johnson

  • Biosynthesis and assembly of the rod outer segment membrane system. Formation and fate of visual pigment in the frog retina

    Michael O. Hall;Dean Bok;A.D.E. Bacharach

  • Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.

    Roxana A. Radu;Yun Han;Tam V. Bui;Steven Nusinowitz

  • Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation.

    Dean Bok;Douglas Yasumura;Michael T. Matthes;Alberto Ruiz

  • Transport of retinol from the blood to the retina: an autoradiographic study of the pigment epithelial cell surface receptor for plasma retinol-binding protein.

    Dean Bok;Dean Bok;Joram Heller;Joram Heller

  • Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells

    Jo-Ling Liao;Juehua Yu;Kevin Huang;Jane Hu

  • Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.

    Roxana A. Radu;Quan Yuan;Jane Hu;Jennifer H. Peng

  • Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling

    Pranab K. Mukherjee;Victor L. Marcheselli;Sebastian Barreiro;Jane Hu

  • Inducible Expression of Vascular Endothelial Growth Factor in Adult Mice Causes Severe Proliferative Retinopathy and Retinal Detachment

    Kyoko Ohno-Matsui;Akira Hirose;Satoru Yamamoto;Jina Saikia

  • Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

    Lincoln V. Johnson;David L. Forest;Christopher D. Banna;Carolyn M. Radeke

  • Evidence for an inflammatory process in age-related macular degeneration gains new support

    Dean Bok

  • Phagocytosis of outer segments by retinal pigment epithelium: phagosome-lysosome interaction.

    E Bosch;J Horwitz;D Bok

Frequent Co-Authors

Gabriel H. Travis
Gabriel H. Travis University of California, Los Angeles
Robert R. Rando
Robert R. Rando University of Padua
Lorraine J. Gudas
Lorraine J. Gudas Cornell University
Matthew M. LaVail
Matthew M. LaVail University of California, San Francisco
Joseph Horwitz
Joseph Horwitz University of California, Los Angeles
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania
Ira Kurtz
Ira Kurtz University of California, Los Angeles
Norbert B. Ghyselinck
Norbert B. Ghyselinck Institute of Genetics and Molecular and Cellular Biology
Enrique Rodriguez-Boulan
Enrique Rodriguez-Boulan Cornell University
Douglas Vollrath
Douglas Vollrath Stanford University

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