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Biology and Biochemistry

D-Index
58
Citations
17049
World Ranking
12964
National Ranking
5524

Overview

Douglas Vollrath is affiliated with Stanford University in the United States. Their research spans multiple scientific disciplines, primarily focusing on biochemistry, genetics, and molecular biology as well as medicine.

Their work covers several subfields including molecular biology, ophthalmology, radiology, nuclear medicine and imaging, neurology, and physiology. Key research topics include glaucoma and retinal disorders, retinal diseases and treatments, retinal development and disorders, barrier structure and function studies, Wnt/β-catenin signaling in development and cancer, cancer-related gene regulation, and erythrocyte function and pathophysiology.

Notable recent publications by Douglas Vollrath include:

  • Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries, 2021, Nature Communications
  • Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice, 2023, Nature Communications
  • An RCS-Like Retinal Dystrophy Phenotype in Mer Knockout Mice, 2021, UNC Libraries
  • Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma, 2023, Scientific Reports
  • Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes, 2023, Ophthalmology

The frequent co-authors collaborating with Douglas Vollrath include:

  • Jessica N. Cooke Bailey
  • Douglas Gaasterland
  • Jonathan L. Haines
  • Yutao Liu
  • Sayoko E. Moroi

Their contributions have been published across several venues, with the most frequent being UNC Libraries, followed by Nature Communications, Scientific Reports, Nature, and Ophthalmology.

Best Publications

  • Separation of large DNA molecules by contour-clamped homogeneous electric fields

    Gilbert Chu;Douglas Vollrath;Ronald W. Davis

  • A gene map of the human genome

    G. D. Schuler;M. S. Boguski;E. A. Stewart;L. D. Stein

  • Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

    Patricia M. D’Cruz;Douglas Yasumura;Jessica Weir;Michael T. Matthes

  • Detection of Numerous Y Chromosome Biallelic Polymorphisms by Denaturing High-Performance Liquid Chromatography

    Peter A. Underhill;Li Jin;Alice A. Lin;S. Qasim Mehdi

  • Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa.

    Andreas Gal;Yun Li;Debra A. Thompson;Jessica Weir

  • Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields.

    Douglas Vollrath;Ronald W. Davis

  • mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

    Chen Zhao;Douglas Yasumura;Xiyan Li;Michael Matthes

  • An electrophoretic karyotype of Neurospora crassa.

    M J Orbach;D Vollrath;R W Davis;C Yanofsky

  • Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk

    Douglas Vollrath;Wei Feng;Jacque L. Duncan;Douglas Yasumura

  • Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

    Janey L. Wiggs;Brian L. Yaspan;Michael A. Hauser;Jae H. Kang

  • Mertk Triggers Uptake of Photoreceptor Outer Segments during Phagocytosis by Cultured Retinal Pigment Epithelial Cells

    Wei Feng;Douglas Yasumura;Michael T. Matthes;Matthew M. LaVail

  • An RCS-like retinal dystrophy phenotype in mer knockout mice.

    Jacque L Duncan;Matthew M LaVail;Douglas Yasumura;Michael T Matthes

  • Reversal of mutant myocilin non-secretion and cell killing: Implications for glaucoma

    Y. Liu;D. Vollrath

  • Genome-wide association analysis identifies TXNRD2 , ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

    Jessica N.Cooke Bailey;Stephanie J. Loomis;Jae H. Kang;R. Rand Allingham

  • Population genetic implications from sequence variation in four Y chromosome genes.

    Peidong Shen;Frank Wang;Peter A. Underhill;Claudia Franco

  • Loss-of-function mutations in the LIM-homeodomain gene, LMX1B, in nail-patella syndrome

    Douglas Vollrath;Virna L. Jaramillo-Babb;Mark V. Clough;Iain McIntosh

  • Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma.

    Satoko Shimizu;Satoko Shimizu;Paul R Lichter;A.Tim Johnson;Zhaohui Zhou

  • Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial

    Nicola G. Ghazi;Emad B. Abboud;Sawsan R. Nowilaty;Hisham Alkuraya

  • Physical mapping of large DNA by chromosome fragmentation.

    Douglas Vollrath;Ronald W. Davis;Carla Connelly;Phillip Hieter

  • Tandem array of human visual pigment genes at Xq28.

    Douglas Vollrath;Jeremy Nathans;Ronald W. Davis

Frequent Co-Authors

Julia E. Richards
Julia E. Richards University of Michigan–Ann Arbor
Janey L. Wiggs
Janey L. Wiggs Massachusetts Eye and Ear Infirmary
Matthew M. LaVail
Matthew M. LaVail University of California, San Francisco
Louis R. Pasquale
Louis R. Pasquale Icahn School of Medicine at Mount Sinai
Donald J. Zack
Donald J. Zack Johns Hopkins University School of Medicine
Yutao Liu
Yutao Liu Augusta University
Michael A. Hauser
Michael A. Hauser Duke University
Joel S. Schuman
Joel S. Schuman Wills Eye Hospital
Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami
Terry Gaasterland
Terry Gaasterland University of California, San Diego

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