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Genetics

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Citations
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1169
National Ranking
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Medicine

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Citations
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Overview

Alex W. Hewitt is affiliated with the University of Tasmania in Australia, focusing on research within medicine and biochemistry, genetics, and molecular biology. Their work intersects several specialized subfields, including ophthalmology, molecular biology, radiology, nuclear medicine, imaging, genetics, and epidemiology.

The scientist's main research topics revolve around glaucoma and retinal disorders, retinal diseases and treatments, retinal imaging and analysis, retinal development and disorders, CRISPR and genetic engineering, corneal surgery and disorders, and pluripotent stem cells research.

Frequent collaboration is a significant aspect of Hewitt's research profile. Notable frequent co-authors include:

  • David A. Mackey
  • Jamie E. Craig
  • Stuart MacGregor
  • Puya Gharahkhani
  • Xikun Han

Their publications are commonly found in a range of scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Ophthalmology
  • JAMA Ophthalmology
  • Nature Communications
  • Scientific Reports

Among the recently published papers, key titles include:

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression, 2021, Nature Genetics
  • Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease, 2022, Science
  • Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries, 2021, Nature Communications
  • Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression, 2020, Nature Genetics
  • Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia, 2020, Nature Genetics

Best Publications

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

    Urmo Võsa;Annique Claringbould;Annique Claringbould;Harm-Jan Westra;Marc Jan Bonder

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

    Lars G. Fritsche;Wilmar Igl;Jessica N.Cooke Bailey;Felix Grassmann

  • Genome-Wide Association Study of Retinopathy in Individuals Without Diabetes

    Richard A. Jensen;Xueling Sim;Xiaohui Li;Mary Frances Cotch

  • Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

    Virginie J M Verhoeven;Pirro G Hysi;Robert Wojciechowski;Robert Wojciechowski;Qiao Fan

  • Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

    Kathryn P Burdon;Stuart Macgregor;Alex W Hewitt;Alex W Hewitt;Shiwani Sharma

  • Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

    Gudmar Thorleifsson;G Bragi Walters;Alex W Hewitt;Alex W Hewitt;Gisli Masson

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Valérie Turcot;Yingchang Lu;Yingchang Lu;Heather M Highland;Heather M Highland;Claudia Schurmann

  • Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

    Yi Lu;Veronique Vitart;Kathryn P. Burdon;Chiea Chuen Khor

  • Genetic influences on handedness: Data from 25,732 Australian and Dutch twin families

    Sarah E. Medland;Sarah E. Medland;David L. Duffy;Margaret J. Wright;Gina M. Geffen

  • A single-cell transcriptome atlas of the adult human retina

    Samuel W. Lukowski;Camden Y. Lo;Alexei A. Sharov;Quan Nguyen

  • Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4.

    Peter Johansson;Lauren G Aoude;Karin Wadt;William J Glasson

  • Genome-wide association analysis identifies TXNRD2 , ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

    Jessica N.Cooke Bailey;Stephanie J. Loomis;Jae H. Kang;R. Rand Allingham

  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25

    Pirro G Hysi;Terri L Young;David A Mackey;David A Mackey;Toby Andrew

  • Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

    Jamie E. Craig;Xikun Han;Xikun Han;Ayub Qassim;Mark Hassall

  • A systematic meta-analysis of genetic association studies for diabetic retinopathy.

    Sotoodeh Abhary;Alex W. Hewitt;Kathryn P. Burdon;Jamie E. Craig

  • Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

    Pirro G Hysi;Ching-Yu Cheng;Henriët Springelkamp;Stuart Macgregor

  • Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

    Pirro G Hysi;Pirro G Hysi;Hélène Choquet;Anthony P Khawaja;Anthony P Khawaja;Robert Wojciechowski

  • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

    Puya Gharahkhani;Kathryn P. Burdon;Kathryn P. Burdon;Rhys Fogarty;Shiwani Sharma

  • Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

    Gabriel Cuellar-Partida;Jamie E Craig;Kathryn Penelope Burdon;Jie Jin Wang

  • Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

    K. P. Burdon;S. MacGregor;A. W. Hewitt;S. Sharma

Frequent Co-Authors

David A. Mackey
David A. Mackey University of Western Australia
Jamie E. Craig
Jamie E. Craig Flinders University
Kathryn P. Burdon
Kathryn P. Burdon University of Tasmania
Stuart MacGregor
Stuart MacGregor QIMR Berghofer Medical Research Institute
Christopher J. Hammond
Christopher J. Hammond King's College London
Jie Jin Wang
Jie Jin Wang University of Sydney
Paul Mitchell
Paul Mitchell University of Sydney
Terri L. Young
Terri L. Young University of Wisconsin–Madison
Nicholas G. Martin
Nicholas G. Martin QIMR Berghofer Medical Research Institute
Grant W. Montgomery
Grant W. Montgomery University of Queensland

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