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Biology and Biochemistry

D-Index
51
Citations
9172
World Ranking
17194
National Ranking
7079

Overview

James E. Melvin is affiliated with the National Institutes of Health in the United States and has contributed to multiple areas within medicine, biochemistry, genetics, molecular biology, and environmental science. Their research integrates aspects of molecular biology, physiology, and cellular and molecular neuroscience, with a focus on related subfields such as oncology, global and planetary change.

The scientist's work covers several key topics, including neuropeptides and animal physiology, protein hydrolysis and bioactive peptides, peptidase inhibition and analysis, erythrocyte function and pathophysiology, S100 proteins and annexins, cell adhesion molecule research, and salivary gland disorders and functions.

Notable recent papers by James E. Melvin include:

  • Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism (2022) published in Frontiers in Drug Discovery
  • Ano6 disruption impairs acinar cell regulatory volume decrease and protein secretion in murine submandibular salivary glands (2020) published in Journal of Cellular Physiology
  • Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands (2024) published in Developmental Biology
  • Antarctic Krill with parasites grow slower than uninfected peers (2025) published in Marine Biology

James E. Melvin collaborates frequently with several researchers, including:

  • Taro Mukaibo
  • Christopher R. Apostol
  • Kelsey Bernard
  • Parthasaradhireddy Tanguturi
  • G Molnár

The scientist's work has appeared across a range of publication venues reflecting interdisciplinary interests:

  • Frontiers in Drug Discovery
  • Journal of Cellular Physiology
  • Developmental Biology
  • Marine Biology

Best Publications

  • The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions

    Paul Denny;Fred K. Hagen;Markus Hardt;Lujian Liao

  • Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

    James E. Melvin;David Yule;Trevor Shuttleworth;Ted Begenisich

  • Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation.

    Carissa M. Krane;James E. Melvin;Ha Van Nguyen;Linda Richardson

  • Mouse Down-regulated in Adenoma (DRA) Is an Intestinal Cl−/HCO3 − Exchanger and Is Up-regulated in Colon of Mice Lacking the NHE3 Na+/H+Exchanger

    James E. Melvin;Keerang Park;Linda Richardson;Patrick J. Schultheis

  • Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)

    Mireya Gonzalez-Begne;Bingwen Lu;Xuemei Han;Fred K. Hagen

  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

    Kazuyoshi Toyama;Heike Wulff;K. George Chandy;Philippe Azam

  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery

    Xibao Liu;Bidhan B. Bandyopadhyay;Tetsuji Nakamoto;Brij B. Singh

  • Systematic comparison of the human saliva and plasma proteomes

    Weihong Yan;Rolf Apweiler;Brian M Balgley;Pinmanee Boontheung

  • Physiological Roles of the Intermediate Conductance, Ca2+-activated Potassium Channel Kcnn4

    Ted Begenisich;Tesuji Nakamoto;Catherine E. Ovitt;Keith Nehrke

  • Tmem16A Encodes the Ca2+-activated Cl− Channel in Mouse Submandibular Salivary Gland Acinar Cells

    Victor G. Romanenko;Marcelo A. Catalán;David A. Brown;Ilva Putzier

  • Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.

    Richard L. Evans;Keerang Park;R. James Turner;Gene E. Watson

  • Activation of calcium-dependent chloride channels in rat parotid acinar cells.

    J Arreola;J E Melvin;T Begenisich

  • Molecular Cloning and Functional Expression of a Rat Na+/H+ Exchanger (NHE5) Highly Expressed in Brain

    Surat Attaphitaya;Keerang Park;James E. Melvin

  • Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex

    Jitesh D. Kawedia;Michelle L. Nieman;Gregory P. Boivin;James E. Melvin

  • The salivary gland fluid secretion mechanism.

    Marcelo A Catalán;Tetsuji Nakamoto;James E Melvin

  • Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice.

    Keith Nehrke;Jorge Arreola;Ha-Van Nguyen;Jodi Pilato

  • Regulation of chloride channels in secretory epithelia.

    T. Begenisich;J.E. Melvin

  • Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene.

    Jorge Arreola;Ted Begenisich;Keith Nehrke;Ha‐Van Nguyen

  • Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.

    Gaspar Peña-Münzenmayer;Marcelo Catalán;Isabel Cornejo;Isabel Cornejo;Carlos D. Figueroa

  • The role of HCO3- and Na+/H+ exchange in the response of rat parotid acinar cells to muscarinic stimulation.

    J E Melvin;A Moran;R J Turner

Frequent Co-Authors

Gary E. Shull
Gary E. Shull University of Cincinnati Medical Center
John R. Yates
John R. Yates Scripps Research Institute
David I. Yule
David I. Yule University of Rochester
David T.W. Wong
David T.W. Wong University of California, Los Angeles
Arthur R. Hand
Arthur R. Hand University of Connecticut
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Indu S. Ambudkar
Indu S. Ambudkar National Institutes of Health
Carlo Brugnara
Carlo Brugnara Boston Children's Hospital
Wolfgang LiedtkeRegeneron
Wolfgang LiedtkeRegeneron Regeneron (United States)
Bruce J. Baum
Bruce J. Baum National Institutes of Health

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