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Biology and Biochemistry

D-Index
65
Citations
16034
World Ranking
9108
National Ranking
613

Overview

Yasunobu Okada is affiliated with Kyoto Prefectural University of Medicine in Japan, focusing research on ion channel regulation and function with extensive work in biochemistry, genetics, and molecular biology.

The scientist's primary research topics include:

  • Ion channel regulation and function
  • Ion Channels and Receptors
  • Cardiac electrophysiology and arrhythmias
  • Ion Transport and Channel Regulation
  • S100 Proteins and Annexins
  • Neuroscience and Neuropharmacology Research
  • Magnesium in Health and Disease

Main fields of study cover biochemistry, genetics, and molecular biology with a notable presence also in neuroscience.

Key subfields of study related to Yasunobu Okada's work include:

  • Molecular Biology
  • Sensory Systems
  • Cardiology and Cardiovascular Medicine
  • Nutrition and Dietetics
  • Physiology

Yasunobu Okada has published several papers, notably:

  • Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation, 2020, Communications Biology
  • Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death, 2021, Frontiers in Cell and Developmental Biology
  • Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 2: Functional and Molecular Properties of ASOR/PAC Channels and Their Roles in Cell Volume Dysregulation and Acidotoxic Cell Death, 2021, Frontiers in Cell and Developmental Biology
  • The ATP-Releasing Maxi-Cl Channel: Its Identity, Molecular Partners, and Physiological/Pathophysiological Implications, 2021, Life
  • Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification, 2024, The Journal of Physiological Sciences

Frequent co-authors in their work include:

  • Tomohiro Numata
  • Kaori Sato
  • Ravshan Z. Sabirov
  • Toshiaki Okada
  • Petr G. Merzlyak

Publication venues commonly featuring Yasunobu Okada's research are:

  • Frontiers in Cell and Developmental Biology
  • The Journal of Physiological Sciences
  • Communications Biology
  • Life
  • Frontiers in Physiology

Best Publications

  • Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.

    Emi Maeno;Yasuki Ishizaki;Toku Kanaseki;Akihiro Hazama

  • LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

    Yuji Hara;Minoru Wakamori;Masakazu Ishii;Emi Maeno;Emi Maeno

  • Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor.

    Y. Okada

  • Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

    Yasunobu Okada;Emi Maeno;Takahiro Shimizu;Katsuya Dezaki

  • Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase

    M V Zamaraeva;R Z Sabirov;E Maeno;Y Ando-Akatsuka

  • Macula densa cell signaling involves ATP release through a maxi anion channel

    Phillip Darwin Bell;Jean-Yves Lapointe;Ravshan Sabirov;Seiji Hayashi

  • Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death.

    Y. Okada;T. Shimizu;E. Maeno;S. Tanabe

  • A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl- channel

    Takahiro Shimizu;Tomohiro Numata;Yasunobu Okada

  • Apoptosis, cell volume regulation and volume-regulatory chloride channels.

    Yasunobu Okada;Emi Maeno

  • TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.

    Tomohiro Numata;Takahiro Shimizu;Yasunobu Okada

  • Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release.

    Ravshan Z. Sabirov;Amal K. Dutta;Yasunobu Okada

  • ATP release via anion channels

    Ravshan Z. Sabirov;Yasunobu Okada

  • Swelling-Induced, Cftr-Independent Atp Release from a Human Epithelial Cell Line: Lack of Correlation with Volume-Sensitive Cl− Channels

    Akihiro Hazama;Akihiro Hazama;Takahiro Shimizu;Takahiro Shimizu;Yuhko Ando-Akatsuka;Seiji Hayashi

  • Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency

    L F Barros;T Kanaseki;R Sabirov;S Morishima

  • Ion channels and transporters involved in cell volume regulation and sensor mechanisms.

    Yasunobu Okada

  • Pathophysiology and puzzles of the volume‐sensitive outwardly rectifying anion channel

    Yasunobu Okada;Kaori Sato;Tomohiro Numata

  • Roles of two types of anion channels in glutamate release from mouse astrocytes under ischemic or osmotic stress.

    Hong-Tao Liu;Bekjan A. Tashmukhamedov;Hana Inoue;Yasunobu Okada;Yasunobu Okada

  • Dual roles of plasmalemmal chloride channels in induction of cell death.

    Yasunobu Okada;Emi Maeno;Takahiro Shimizu;Kenichi Manabe

  • TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

    Takahiro Shimizu;Takahiro Iehara;Kaori Sato;Takuto Fujii

  • Direct mechano-stress sensitivity of TRPM7 channel.

    Tomohiro Numata;Takahiro Shimizu;Yasunobu Okada

Frequent Co-Authors

Makoto Tominaga
Makoto Tominaga National Institutes of Natural Sciences
Yasuo Mori
Yasuo Mori Kyoto University
Minoru Horie
Minoru Horie Shiga University of Medical Science
Yoichi Ueta
Yoichi Ueta University of Occupational and Environmental Health Japan
Carl C. H. Petersen
Carl C. H. Petersen École Polytechnique Fédérale de Lausanne
Sei Sasaki
Sei Sasaki Tokyo Medical and Dental University
Seiji Shioda
Seiji Shioda Shonan University of Medical Sciences
Shinichi Uchida
Shinichi Uchida Tokyo Medical and Dental University
Kimitoshi Kohno
Kimitoshi Kohno University of Occupational and Environmental Health Japan
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University

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