World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
11092
World Ranking
18603
National Ranking
7605

Overview

Carl D. Bortner is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, they focus on subfields including Molecular Biology, Immunology, Pulmonary and Respiratory Medicine, Cancer Research, and Endocrinology, Diabetes and Metabolism.

The scientist's work covers several main topics, which include:

  • Ferroptosis and cancer prognosis
  • Cancer, Lipids, and Metabolism
  • RNA modifications and cancer
  • Cell death mechanisms and regulation
  • Immune Response and Inflammation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Eicosanoids and Hypertension Pharmacology

Recent publications by Carl D. Bortner illustrate their focus on cell death and molecular mechanisms. Selected papers include:

  • "Apoptotic cell death in disease-Current understanding of the NCCD 2023" (2023) published in Cell Death and Differentiation
  • "Ions, the Movement of Water and the Apoptotic Volume Decrease" (2020) published in Frontiers in Cell and Developmental Biology
  • "Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood" (2020) published in The Journal of Immunology
  • "Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung" (2023) published in JCI Insight
  • "Ferroptosis-Mediated Cell Death Induced by NCX4040, The Non-Steroidal Nitric Oxide Donor, in Human Colorectal Cancer Cells: Implications in Therapy" (2023) published in Cells

Frequent coauthors collaborating with Carl D. Bortner include:

  • John A. Cidlowski
  • Birandra K. Sinha
  • Erik J. Tokar
  • Maria Grazia Petrillo
  • Jian-Liang Li

Their research findings have been disseminated repeatedly in publication venues such as:

  • International Journal of Molecular Sciences
  • Preprints.org
  • UNC Libraries
  • Cell Death and Differentiation
  • Frontiers in Cell and Developmental Biology

Best Publications

  • The role of DNA fragmentation in apoptosis.

    Carl D. Bortner;Nicklas B.E. Oldenburg;John A. Cidlowski

  • A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis

    Carl D. Bortner;Francis M. Hughes;John A. Cidlowski

  • Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.

    Carol S Trempus;Rebecca J Morris;Carl D Bortner;George Cotsarelis

  • Intracellular K+ Suppresses the Activation of Apoptosis in Lymphocytes

    Francis M. Hughes;Carl D. Bortner;Geoffrey D. Purdy;John A. Cidlowski

  • Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis.

    Carl D. Bortner;John A. Cidlowski

  • A necessary role for cell shrinkage in apoptosis

    Carl D. Bortner;John A. Cidlowski

  • Cell shrinkage and monovalent cation fluxes: role in apoptosis.

    Carl D. Bortner;John A. Cidlowski

  • Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

    C. D. Bortner;J. A. Cidlowski

  • Apoptotic volume decrease and the incredible shrinking cell.

    C D Bortner;J A Cidlowski

  • Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity.

    Po See Chen;Chao-Chuan Wang;Chao-Chuan Wang;Carl D. Bortner;Giia-Sheun Peng;Giia-Sheun Peng

  • Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death.

    Carl D. Bortner;John A. Cidlowski

  • Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death

    Janine Hertzog Santos;L'uba Hunakova;Yiming Chen;Carl Bortner

  • Plasma Membrane Depolarization without Repolarization Is an Early Molecular Event in Anti-Fas-induced Apoptosis

    Carl D. Bortner;Mireia Gómez-Angelats;John A. Cidlowski

  • Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells ANALYSIS OF APOPTOSIS AND CELL DEATH

    Danielle R. Mercatante;Carl D. Bortner;John A. Cidlowski;Ryszard Kole

  • The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis

    Carl D. Bortner;John A. Cidlowski

  • CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

    Carol S. Trempus;Rebecca J. Morris;Matthew Ehinger;Amy Elmore

  • Protein kinase C (PKC) inhibits fas receptor-induced apoptosis through modulation of the loss of K+ and cell shrinkage. A role for PKC upstream of caspases.

    Mireia Gómez-Angelats;Carl D. Bortner;John A. Cidlowski

  • The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system.

    Cidlowski Ja;King Kl;Evans-Storms Rb;Montague Jw

  • Cellular mechanisms for the repression of apoptosis.

    Carl D. Bortner;John A. Cidlowski

  • Ion channels and apoptosis in cancer

    Carl D. Bortner;John A. Cidlowski

Frequent Co-Authors

John A. Cidlowski
John A. Cidlowski National Institutes of Health
Anton M. Jetten
Anton M. Jetten National Institutes of Health
Michael P. Waalkes
Michael P. Waalkes National Institutes of Health
Rodrigo Franco
Rodrigo Franco University of Nebraska–Lincoln
Raymond W. Tennant
Raymond W. Tennant National Institutes of Health
Donald N. Cook
Donald N. Cook National Institutes of Health
Florian Lang
Florian Lang University of Tübingen
Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health
George Cotsarelis
George Cotsarelis University of Pennsylvania
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill

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