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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
8243
World Ranking
17709
National Ranking
20

Overview

Sergei N. Orlov was affiliated with Lomonosov Moscow State University in the Russian Federation. Their research primarily focused on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a substantial emphasis on Molecular Biology and related subfields.

Their scientific work covered a range of topics, including:

  • Ion Transport and Channel Regulation
  • Hormonal Regulation and Hypertension
  • Ion channel regulation and function
  • Phytochemistry and Bioactive Compounds
  • Hemoglobin structure and function
  • Erythrocyte Function and Pathophysiology
  • Exercise and Physiological Responses

Among the frequent publication venues where Orlov contributed were:

  • Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology
  • International Journal of Molecular Sciences
  • Biochemistry (Moscow)
  • Genes & Diseases
  • Frontiers in Physiology

Orlov's notable recent papers included:

  • "Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?" (2020), published in Genes & Diseases
  • "Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression" (2020), published in Frontiers in Physiology
  • "Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids" (2021), published in International Journal of Molecular Sciences
  • "Neural population dynamics reveals disruption of spinal circuits' responses to proprioceptive input during electrical stimulation of sensory afferents" (2024), published in Cell Reports
  • "In vitro assay for the efficacy assessment of AAV vectors expressing microdystrophin" (2020), published in Experimental Cell Research

They worked closely with a group of frequent co-authors, including:

  • Е. А. Климанова
  • Svetlana V. Sidorenko
  • O. D. Lopina
  • Artem M. Tverskoi
  • Г. В. Максимов

The subfields within the main areas of study encompassed Molecular Biology, Physiology, Endocrinology, Diabetes and Metabolism, Cognitive Neuroscience, and Cellular and Molecular Neuroscience.

Sergei N. Orlov's career contributed to advancing understanding in biochemical and physiological mechanisms, particularly related to ion transport and hormonal regulation. Their body of work extended over multiple years, and their findings were disseminated mainly through scientific journals specializing in molecular sciences and biochemistry.

Best Publications

  • Apoptosis in Target Organs of Hypertension

    Pavel Hamet;Lucie Richard;Than-Vinh Dam;Emmanuel Teiger

  • Altered permeability of the erythrocyte membrane for sodium and potassium ions in spontaneously hypertensive rats.

    Y.V. Postnov;S.N. Orlov;P.V. Gulak;A.S. Shevchenko

  • Ion transport across plasma membrane in primary hypertension

    Y. V. Postnov;S. N. Orlov

  • Decrease of calcium binding by the red blood cell membrane in spontaneously hypertensive rats and in essential hypertension.

    Yu. V. Postnov;S. N. Orlov;N. I. Pokudin

  • Mechanisms of cell volume regulation and possible nature of the cell volume sensor.

    Alexander A. Mongin;Sergei N. Orlov;Sergei N. Orlov

  • Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3.

    Sergei N. Orlov;Sergei N. Orlov;Nathalie Thorin-Trescases;Sergei V. Kotelevtsev;Johanne Tremblay

  • Salt-sensing mechanisms in blood pressure regulation and hypertension

    Sergei N. Orlov;Alexander A. Mongin

  • Proteome Analysis and Functional Expression Identify Mortalin as an Antiapoptotic Gene Induced by Elevation of [Na+]i/[K+]i Ratio in Cultured Vascular Smooth Muscle Cells

    Sebastien Taurin;Volkan Seyrantepe;Sergei N. Orlov;Tammy-Lynn Tremblay

  • Cell membrane alteration as a source of primary hypertension.

    Yuvenali V. Postnov;Sergei N. Orlov

  • Membrane reserves and hypotonic cell swelling.

    Nicolas Groulx;Francis Boudreault;Sergei N. Orlov;Ryszard Grygorczyk

  • Intracellular Monovalent Ions as Second Messengers

    S.N. Orlov;P. Hamet

  • Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3

    Sergei N Orlov;Nathalie Thorin-Trescases;Nickolai O Dulin;Than-Vinh Dam

  • Hemolysis is a primary ATP-release mechanism in human erythrocytes

    Jacek Sikora;Sergei N. Orlov;Kishio Furuya;Ryszard Grygorczyk

  • Ca2+ Binding and Membrane Fluidity in Essential and Renal Hypertension

    Sergei N. Orlov;Yuvenali V. Postnov

  • The time window of apoptosis: a new component in the therapeutic strategy for cardiovascular remodeling.

    P. Hamet;P. Moreau;T.-V. Dam;S. N. Orlov

  • Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension.

    Sergei N. Orlov;Sergei N. Orlov;Norma C. Adragna;Viacheslav A. Adarichev;Pavel Hamet

  • Cardiotonic Steroids Differentially Affect Intracellular Na+ and [Na+]i/[K+]i-independent Signaling in C7-MDCK Cells

    Olga A. Akimova;Olga A. Akimova;Alexei Y. Bagrov;Olga D. Lopina;Alexey V. Kamernitsky

  • Protection Against Necrosis but Not Apoptosis by Heat-Stress Proteins in Vascular Smooth Muscle Cells: Evidence for Distinct Modes of Cell Death

    Marie-Josée Champagne;Pierre Dumas;Sergei N. Orlov;Martin R. Bennett

  • K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation.

    Norma C. Adragna;Richard E. White;Sergei N. Orlov;Peter K. Lauf

  • Quantitative Founder-Effect Analysis of French Canadian Families Identifies Specific Loci Contributing to Metabolic Phenotypes of Hypertension

    P. Hamet;E. Merlo;O. Šeda;U. Broeckel

Frequent Co-Authors

Pavel Hamet
Pavel Hamet University of Montreal
Gerald Maurer
Gerald Maurer Medical University of Vienna
Alison H. Goodall
Alison H. Goodall University of Leicester
Timothy O'Brien
Timothy O'Brien University of Minnesota
Michael Laffan
Michael Laffan Imperial College London
Robert S. Reneman
Robert S. Reneman Maastricht University
Michael Gekle
Michael Gekle Martin Luther University Halle-Wittenberg
Martin Lauritzen
Martin Lauritzen University of Copenhagen
Martin Fabricius
Martin Fabricius University of Copenhagen

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