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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
11411
World Ranking
10426
National Ranking
753

Overview

Michael Gekle is affiliated with Martin Luther University Halle-Wittenberg in Germany and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans various subfields including Molecular Biology, Clinical Psychology, Infectious Diseases, Neurology, and Cardiology and Cardiovascular Medicine.

The scientist's work covers several main topics, prominently focusing on COVID-19 and Mental Health, Long-Term Effects of COVID-19, and COVID-19 Clinical Research Studies. Additional areas of research include Receptor Mechanisms and Signaling, SARS-CoV-2 and COVID-19 Research, Hormonal Regulation and Hypertension, and Renin-Angiotensin System Studies.

Among their recent publications are:

  • The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19 (2022, Cell Reports Medicine)
  • The risk of indoor sports and culture events for the transmission of COVID-19 (2021, Nature Communications)
  • Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19 (2022, Journal of Medical Virology)
  • Angiotensin II receptor type 1 - An update on structure, expression and pathology (2021, Biochemical Pharmacology)
  • Association between virus variants, vaccination, previous infections, and post-COVID-19 risk (2023, International Journal of Infectious Diseases)

Frequent co-authors with whom Michael Gekle has collaborated include Rafael Mikolajczyk, Cornelia Gottschick, Bianca Klee, Matthias Girndt, and Mascha Binder.

Publication venues frequently featuring their work include bioRxiv (Cold Spring Harbor Laboratory), SSRN Electronic Journal, Biomedicines, Scientific Reports, and Biochemical Pharmacology.

Best Publications

  • Renal tubule albumin transport.

    Michael Gekle

  • Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney

    Xiao Yue Zhai;Rikke Nielsen;Rikke Nielsen;Rikke Nielsen;Henrik Birn;Henrik Birn;Henrik Birn;Karina Drumm;Karina Drumm;Karina Drumm

  • Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties.

    Michael Gekle;Stefan Wünsch;Hans Oberleithner;Stefan Silbernagl

  • Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions.

    Claudia Grossmann;Andreas Benesic;Alexander W. Krug;Ruth Freudinger

  • Nephrotoxicity of platinum complexes is related to basolateral organic cation transport

    Thomas Ludwig;Christoph Riethmüller;Christoph Riethmüller;Michael Gekle;Michael Gekle;Gerald Schwerdt;Gerald Schwerdt

  • Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance.

    Michael Gekle;Nikola Golenhofen;Hans Oberleithner;Stefan Silbernagl

  • Angiotensin Converting Enzyme Inhibition and Angiotensin II AT1-Receptor Blockade Reduce the Levels of Asymmetrical NG, NG-Dimethylarginine in Human Essential Hypertension*

    Christian Delles;Markus P Schneider;Stefan John;Michael Gekle

  • Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs.

    Oliver Thews;Birgit Gassner;Debra K Kelleher;Gerald Schwerdt

  • Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

    Anne Riemann;Bettina Schneider;Angelika Ihling;Martin Nowak

  • Inhibition of Na+‐H+ exchange impairs receptor‐mediated albumin endocytosis in renal proximal tubule‐derived epithelial cells from opossum

    Michael Gekle;Karina Drumm;Sigrid Mildenberger;Ruth Freudinger

  • Aldosterone stimulates epidermal growth factor receptor expression.

    Alexander W. Krug;Claudia Grossmann;Claudia Schuster;Ruth Freudinger

  • New aspects of rapid aldosterone signaling

    C. Grossmann;M. Gekle

  • Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

    Alexander W. Krug;Lena Allenhöfer;Robert Monticone;Gaia Spinetti

  • Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum

    Stefan Wünsch;Cecilia P. Sanchez;Michael Gekle;Lars Große-Wortmann

  • Rapid activation of Na + /H + -exchange in MDCK cells by aldosterone involves MAP-kinases ERK 1/2

    Michael Gekle;Ruth Freudinger;Sigrid Mildenberger;Kai Schenk

  • Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.

    Michael Gekle;Gerald Schwerdt;Ruth Freudinger;Sigrid Mildenberger

  • Transforming growth factor‐β1 reduces megalin‐ and cubilin‐mediated endocytosis of albumin in proximal‐tubule‐derived opossum kidney cells

    Michael Gekle;Petra Knaus;Rikke Nielsen;Sigrid Mildenberger

  • Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells.

    Michael Gekle;Christoph Sauvant;Gerald Schwerdt

  • Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.

    Christoph Sauvant;Martin Nowak;Claudia Wirth;Bettina Schneider

  • The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells.

    G Schwerdt;R Freudinger;S Mildenberger;S Silbernagl

Frequent Co-Authors

Hans-Christian Pape
Hans-Christian Pape University of Münster
Hans Oberleithner
Hans Oberleithner University of Münster
Malte Kelm
Malte Kelm Heinrich Heine University Düsseldorf
Andreas Draguhn
Andreas Draguhn Heidelberg University
Ulrike M. Krämer
Ulrike M. Krämer University of Lübeck
Heiko J. Luhmann
Heiko J. Luhmann Johannes Gutenberg University of Mainz
Ulf T. Eysel
Ulf T. Eysel Ruhr University Bochum
Hans-Ulrich Humpf
Hans-Ulrich Humpf University of Münster
Christoph Wanner
Christoph Wanner University of Würzburg
Sergei N. Orlov
Sergei N. Orlov Lomonosov Moscow State University

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