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Min-Xin Guan

Min-Xin Guan

D-Index & Metrics

Genetics

D-Index
66
Citations
13831
World Ranking
2633
National Ranking
70

Overview

Min-Xin Guan is affiliated with Zhejiang University in China and specializes in Biochemistry, Genetics and Molecular Biology with a total of 127 publications in this field. Their research interest is strongly focused on Molecular Biology, which accounts for 110 of their works, along with contributions to Clinical Biochemistry, Sensory Systems, Cancer Research, and Neurology.

The scientist's main topics of study include:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Metabolism and Genetic Disorders
  • Hearing, Cochlea, Tinnitus, Genetics
  • RNA Research and Splicing

Min-Xin Guan has published in several prominent journals multiple times. Frequent publication venues encompass:

  • Journal of Biological Chemistry (10 publications)
  • Nucleic Acids Research (6 publications)
  • JCI Insight (4 publications)
  • Human Molecular Genetics (4 publications)
  • PubMed (4 publications)

Recent papers authored or co-authored by Min-Xin Guan include:

  • ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA, 2021, The EMBO Journal
  • Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, 2022, Nature Communications
  • Emerging functions of mitochondria-encoded noncoding RNAs, 2022, Trends in Genetics
  • PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy, 2020, Journal of Clinical Investigation
  • A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation, 2020, Nucleic Acids Research

Their network of frequent coauthors reflects collaborations with the following researchers:

  • Yanchun Ji (17 collaborations)
  • Feilong Meng (14 collaborations)
  • Juanjuan Zhang (13 collaborations)
  • Meng Wang (9 collaborations)
  • Qiuzi Yi (9 collaborations)

Overall, Min-Xin Guan's scientific contributions cover diverse aspects of mitochondrial biology, RNA processes, and genetic mechanisms related to metabolism and sensory systems, supported by extensive publication activity in leading journals and active collaborative research.

Best Publications

  • DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

    C. E. Aalseth;F. Acerbi;P. Agnes;I. F. M. Albuquerque

  • Maternally inherited aminoglycoside-induced and nonsyndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family.

    Hui Zhao;Ronghua Li;Qiuju Wang;Qingfeng Yan

  • Biochemical Evidence for Nuclear Gene Involvement in Phenotype of Non-Syndromic Deafness Associated with Mitochondrial 12S rRNA Mutation

    Min-Xin Guan;Nathan Fischel-Ghodsian;Giuseppe Attardi

  • Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss

    Zhiyuan Li;Ronghua Li;Jianfu Chen;Zhisu Liao

  • Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations

    Min-Xin Guan;Min-Xin Guan;Qingfeng Yan;Xiaoming Li;Yelena Bykhovskaya

  • The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

    Qianqian Li;Zewen Gao;Ye Chen;Min-Xin Guan

  • A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity

    Min-Xin Guan;Nathan Fischel-Ghodsian;Giuseppe Attardi

  • Species identification through mitochondrial rRNA genetic analysis

    Li Yang;Zongqing Tan;Daren Wang;Ling Xue

  • Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation

    Min-Xin Guan;Nathan Fischel-Ghodsian;Giuseppe Attardi

  • Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

    Nuno Raimundo;Lei Song;Timothy E. Shutt;Sharen E. McKay

  • Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss.

    Ronghua Li;Guangqian Xing;Ming Yan;Xing Cao

  • Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity

    Min-Xin Guan

  • The Deafness-Associated Mitochondrial DNA Mutation at Position 7445, Which Affects tRNASer(UCN) Precursor Processing, Has Long-Range Effects on NADH Dehydrogenase Subunit ND6 Gene Expression

    Min-Xin Guan;José Antonio Enriquez;Nathan Fischel-Ghodsian;Ram S. Puranam

  • Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNALeu(UUR) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes

    Ronghua Li;Min-Xin Guan;Min-Xin Guan

  • Isolation and Characterization of the Putative Nuclear Modifier Gene MTO1 Involved in the Pathogenesis of Deafness-associated Mitochondrial 12 S rRNA A1555G Mutation

    Xiaoming Li;Ronghua Li;Xinhua Lin;Min-Xin Guan

  • Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness

    Xiaoming Li;Nathan Fischel‐Ghodsian;Faina Schwartz;Qingfeng Yan

  • The novel A4435G mutation in the mitochondrial tRNAMet may modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation.

    Jia Qu;Ronghua Li;Xiangtian Zhou;Yi Tong

  • Molecular pathogenetic mechanism of maternally inherited deafness.

    Min-Xin Guan

  • Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss

    Jianxin Lu;Zhiyuan Li;Yi Zhu;Aifen Yang

  • Prevalence of Mitochondrial 12S rRNA Mutations Associated with Aminoglycoside Ototoxicity.

    Min-Xin Guan

Frequent Co-Authors

Jia Qu
Jia Qu Wenzhou Medical University
J. Napolitano
J. Napolitano Temple University

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