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Chemistry

D-Index
58
Citations
12436
World Ranking
10586
National Ranking
604

Overview

Stephen Caddick is affiliated with University College London in the United Kingdom and has conducted research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Radiology, Nuclear Medicine and Imaging, Molecular Biology, Oncology, Organic Chemistry, and Biochemistry.

They have contributed to the following topical areas:

  • Monoclonal and Polyclonal Antibodies Research
  • Glycosylation and Glycoproteins Research
  • Click Chemistry and Applications
  • HER2/EGFR in Cancer Research
  • Pancreatic and Hepatic Oncology Research
  • Phytochemical compounds biological activities
  • Traditional and Medicinal Uses of Annonaceae

Recent publications by Stephen Caddick include:

  • A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics, 2020, Bioconjugate Chemistry
  • Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer, 2020, British Journal of Cancer
  • Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents, 2023, ChemMedChem
  • Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis, 2021, Organic & Biomolecular Chemistry
  • Front Cover: Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents (ChemMedChem 13/2023), 2023, ChemMedChem

Frequent co-authors associated with their research include:

  • James R. Baker
  • Vijay Chudasama
  • Késsia H. S. Andrade
  • Jaime A. S. Coelho
  • Raquel F. M. Frade

The venues where Stephen Caddick has most commonly published are:

  • ChemMedChem
  • Bioconjugate Chemistry
  • British Journal of Cancer
  • Organic & Biomolecular Chemistry

Best Publications

  • Microwave assisted organic reactions

    S. Caddick

  • Palladium reagents and catalysts: Innovation on Organic synthesis

    Unknown

  • Microwave enhanced synthesis

    Stephen Caddick;Richard Fitzmaurice

  • Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

    Mark E. B. Smith;Felix F. Schumacher;Chris P. Ryan;Lauren M. Tedaldi

  • Recent advances in the construction of antibody–drug conjugates

    Vijay Chudasama;Antoine Maruani;Stephen Caddick

  • Dynamic resolutions in asymmetric synthesis

    S. Caddick;K. Jenkins

  • A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

    Antoine Maruani;Mark E.B. Smith;Enrique Miranda;Kerry A. Chester

  • Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids.

    Stephen Caddick;Jonathan D Wilden;Duncan B Judd

  • A generic approach for the catalytic reduction of nitriles

    Stephen Caddick;Duncan B Judd;Alexandra K.de K Lewis;Melanie T Reich

  • Unusual Reactivity of a Nickel N‐Heterocyclic Carbene Complex: tert‐Butyl Group Cleavage and Silicone Grease Activation

    Stephen Caddick;F. Geoffrey N. Cloke;Peter B. Hitchcock;Alexandra K. de K. Lewis

  • Hydroacylation of α,β-unsaturated esters via aerobic C–H activation

    Vijay Chudasama;Richard J. Fitzmaurice;Stephen Caddick

  • Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents

    Mathew W. Jones;Rachel A. Strickland;Felix F. Schumacher;Stephen Caddick

  • In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

    Schumacher Ff;Nobles M;Ryan Cp;Smith Me

  • Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

    Felix F. Schumacher;João P. M. Nunes;Antoine Maruani;Vijay Chudasama

  • Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: Relevance to catalytic amination

    Alexandra K de K Lewis;Stephen Caddick;F Geoffrey N Cloke;Norman C Billingham

  • Suzuki–Miyaura cross-coupling of aryl and alkyl halides using palladium/imidazolium salt protocols

    Katherine Arentsen;Stephen Caddick;F.Geoffrey N Cloke;Adam P Herring

  • Tuning the Reactivity of Dirhodium(II) Complexes with Axial N‐Heterocyclic Carbene Ligands: The Arylation of Aldehydes

    Pedro M. P. Gois;Pedro M. P. Gois;Pedro M. P. Gois;Alexandre F. Trindade;Luís F. Veiros;Vania André

  • Unexpected reactivity of two-coordinate palladium carbene complexes; synthetic and catalytic implications

    Lisa R. Titcomb;Stephen Caddick;F. Geoffrey N. Cloke;D. James Wilson

  • Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

    João P. M. Nunes;Maurício Morais;Vessela Vassileva;Eifion Robinson

  • Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.

    Belinda Loh;Luciano Vozzolo;B. James Mok;Chien Chi Lee

  • Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

    Chris P. Ryan;Mark E. B. Smith;Felix F. Schumacher;Dina Grohmann

Frequent Co-Authors

F. Geoffrey N. Cloke
F. Geoffrey N. Cloke University of Sussex
Carlos A. M. Afonso
Carlos A. M. Afonso University of Lisbon
Peter B. Hitchcock
Peter B. Hitchcock University of Sussex
Derek A. Tocher
Derek A. Tocher University College London
Luis F. Veiros
Luis F. Veiros Instituto Superior Técnico
Derek N. Woolfson
Derek N. Woolfson University of Bristol
Mark E. Smith
Mark E. Smith University of Southampton
William B. Motherwell
William B. Motherwell University College London
Rachel C. Chambers
Rachel C. Chambers University College London
Gabriel Waksman
Gabriel Waksman University College London

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