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Biology and Biochemistry

D-Index
80
Citations
19927
World Ranking
4153
National Ranking
311

Overview

Derek N. Woolfson is a researcher affiliated with the University of Bristol in the United Kingdom. Their work primarily spans the field of Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Biomaterials, Materials Chemistry, Cell Biology, and Infectious Diseases as specialized subfields.

The scientific inquiry focuses on several main topics, including:

  • Protein Structure and Dynamics
  • Chemical Synthesis and Analysis
  • RNA and protein synthesis mechanisms
  • Enzyme Structure and Function
  • Supramolecular Self-Assembly in Materials
  • Microtubule and mitosis dynamics
  • Glycosylation and Glycoproteins Research

The research output includes publications in prominent venues, with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Chemical Science, Zenodo (CERN European Organization for Nuclear Research), Nature Chemistry, and Nature Communications.

Recent notable papers include:

  • "A Brief History of De Novo Protein Design: Minimal, Rational, and Computational," 2021, Journal of Molecular Biology
  • "An atlas of protein homo-oligomerization across domains of life," 2024, Cell
  • "Constructing ion channels from water-soluble α-helical barrels," 2021, Nature Chemistry
  • "Understanding a protein fold: The physics, chemistry, and biology of α-helical coiled coils," 2023, Journal of Biological Chemistry
  • "BAlaS: fast, interactive and accessible computational alanine-scanning using BudeAlaScan," 2020, Bioinformatics

Collaborations have been frequently established with colleagues such as William Dawson, Jessica A. Cross, Judith Mantell, Andrey Romanyuk, and Mark P. Dodding, with multiple coauthored publications indicating ongoing research partnerships.

Best Publications

  • The design of coiled-coil structures and assemblies

    Derek N Woolfson

  • Self-Assembling Cages from Coiled-Coil Peptide Modules

    Jordan M. Fletcher;Robert L. Harniman;Frederick R. H. Barnes;Aimee L. Boyle

  • Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Chrisostomos Prodromou;Giuliano Siligardi;Ronan O'Brien;Derek N. Woolfson

  • Rational design and application of responsive α-helical peptide hydrogels

    Eleanor F. Banwell;Edgardo S. Abelardo;Edgardo S. Abelardo;Dave J. Adams;Martin A. Birchall

  • Carbohydrate–Aromatic Interactions in Proteins

    Kieran L. Hudson;Gail J. Bartlett;Roger C. Diehl;Jon Agirre

  • Socket: a program for identifying and analysing coiled-coil motifs within protein structures

    John Walshaw;Derek N Woolfson

  • Sticky-end assembly of a designed peptide fiber provides insight into protein fibrillogenesis.

    Maya J. Pandya;Gillian M. Spooner;Margaret Sunde;Julian R. Thorpe

  • n → π * interactions in proteins

    Gail J Bartlett;Amit Choudhary;Ronald T Raines;Derek N Woolfson

  • Computational design of water-soluble α-helical barrels

    Andrew R. Thomson;Christopher W. Wood;Antony J. Burton;Gail J. Bartlett

  • Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

    Giuliano Siligardi;Barry Panaretou;Philippe Meyer;Shradha Singh

  • A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology

    Jordan M. Fletcher;Aimee L. Boyle;Marc Bruning;Gail J. Bartlett

  • Engineering the morphology of a self-assembling protein fibre

    Maxim G. Ryadnov;Derek N. Woolfson

  • Buried polar residues and structural specificity in the GCN4 leucine zipper.

    Lino Gonzalez;Derek N. Woolfson;Tom Alber

  • Peptide-based fibrous biomaterials: Some things old, new and borrowed.

    Derek N Woolfson;Maxim G Ryadnov

  • Engineering nanoscale order into a designed protein fiber

    David Papapostolou;Andrew M. Smith;Edward D. T. Atkins;Seb J. Oliver

  • Predicting oligomerization states of coiled coils

    Derek N. Woolfson;Tom Alber

  • Peptide and Protein Building Blocks for Synthetic Biology: From Programming Biomolecules to Self-Organized Biomolecular Systems

    Elizabeth H. C. Bromley;Kevin Channon;Efrosini Moutevelis;Derek N. Woolfson

  • More than just bare scaffolds: towards multi-component and decorated fibrous biomaterials

    Derek N. Woolfson;Zahra N. Mahmoud

  • Determinants of strand register in antiparallel beta-sheets of proteins

    EG Hutchinson;RB Sessions;JM Thornton;DN Woolfson

  • A periodic table of coiled-coil protein structures.

    Efrosini Moutevelis;Derek N. Woolfson

Frequent Co-Authors

Richard B. Sessions
Richard B. Sessions University of Bristol
Paul M. G. Curmi
Paul M. G. Curmi University of New South Wales
Paul Verkade
Paul Verkade University of Bristol
Stephen Caddick
Stephen Caddick University College London
Matthew P. Crump
Matthew P. Crump University of Bristol
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison
Dudley H. Williams
Dudley H. Williams University of Cambridge
Adrian J. Mulholland
Adrian J. Mulholland University of Bristol
Tom Alber
Tom Alber University of California, Berkeley
Louise C. Serpell
Louise C. Serpell University of Sussex

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