World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
56
Citations
11702
World Ranking
2204
National Ranking
174

Overview

Rachel C. Chambers is affiliated with University College London in the United Kingdom and has produced extensive research primarily in the field of Medicine. Their work spans several subfields, with the most publications in Pulmonary and Respiratory Medicine, followed by Infectious Diseases, Molecular Biology, Neurology, and Physiology.

The research topics covered by Chambers include a significant focus on Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis, COVID-19 Clinical Research Studies, and Long-Term Effects of COVID-19. Other notable areas of study involve SARS-CoV-2 and COVID-19 Research, Respiratory Support and Mechanisms, Chronic Obstructive Pulmonary Disease (COPD) Research, and Medical Imaging and Pathology Studies.

The scientist has published multiple papers in widely recognized venues. Recent publications include:

  • Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities, 2020, The Lancet Respiratory Medicine
  • Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID-19 Study, 2022, American Journal of Respiratory and Critical Care Medicine
  • Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis, 2020, Nature Communications
  • Human SARS-CoV-2 challenge uncovers local and systemic response dynamics, 2024, Nature
  • Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis, 2021, Science Signaling

Chambers frequently collaborates with other researchers, including Puja Mehta, Manuela Platé, Joanna C. Porter, Gísli Jenkins, and Iain Stewart. These collaborations contribute notably to the breadth and depth of their research outputs.

The primary venues for Chambers's publications feature bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, The Lancet Rheumatology, European Respiratory Review, and Thorax. These journals highlight the scientist's engagement with both preprint platforms and peer-reviewed medical and respiratory research outlets.

Best Publications

  • Molecular Targets in Pulmonary Fibrosis: The Myofibroblast in Focus

    Unknown

  • Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.

    Rachael A Evans;Hamish McAuley;Ewen M Harrison;Aarti Shikotra

  • Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

    R. Gisli Jenkins;Xiao Su;George Su;Christopher J. Scotton

  • The pathogenesis of pulmonary fibrosis: a moving target

    Wim A Wuyts;Carlo Agostini;Katerina M Antoniou;Demosthenes Bouros

  • Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-β1 Reveals the Induction of Inhibitor of Differentiation-1 and Provides Evidence of Smooth Muscle Cell Phenotypic Switching

    Rachel C. Chambers;Patricia Leoni;Naftali Kaminski;Geoffrey J. Laurent

  • Thrombin Is a Potent Inducer of Connective Tissue Growth Factor Production via Proteolytic Activation of Protease-activated Receptor-1

    Rachel C. Chambers;Patricia Leoni;Olivier P. Blanc-Brude;David E. Wembridge

  • Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch

    Ching-Hsin Ku;Philip H. Johnson;Puspa Batten;Padmini Sarathchandra

  • Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1.

    Rachel C. Chambers;Karim Dabbagh;Robin J. McANULTY;Andy J. Gray

  • Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

    Vitor H. Teixeira;Christodoulos P. Pipinikas;Adam Pennycuick;Henry Lee-Six

  • A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

    Chris J. C. Johnston;Danielle J. Smyth;Danielle J. Smyth;Ravindra B. Kodali;Madeleine P. J. White

  • Activation of Fibroblast Procollagen α1(I) Transcription by Mechanical Strain Is Transforming Growth Factor-β-dependent and Involves Increased Binding of CCAAT-binding Factor (CBF/NF-Y) at the Proximal Promoter

    Gisela E. Lindahl;Rachel C. Chambers;Jenny Papakrivopoulou;Sally J. Dawson

  • The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

    Hannah V. Woodcock;Jessica D. Eley;Delphine Guillotin;Manuela Platé

  • Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

    Paul F Mercer;Hannah V Woodcock;Jessica D Eley;Manuela Platé

  • Molecules in focus Thrombin

    Neil R Goldsack;Rachel C Chambers;Karim Dabbagh;Geoffrey J Laurent

  • mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.

    Unknown

  • Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats.

    Steven E. Mutsaers;Martyn L. Foster;Rachel C. Chambers;Geoffrey J. Laurent

  • Coagulation cascade proteases and tissue fibrosis.

    R. C. Chambers;G. J. Laurent

  • Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation.

    Olivier P. Blanc-Brude;Fabienne Archer;Patricia Leoni;Claudia Derian

  • Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways.

    Karim Dabbagh;Geoffrey J. Laurent;Anthony Shock;Patricia Leoni

  • Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism.

    K Dabbagh;G J Laurent;R J McAnulty;R C Chambers

Frequent Co-Authors

Geoffrey J. Laurent
Geoffrey J. Laurent University College London
Toby M. Maher
Toby M. Maher University of Southern California
David W. Ray
David W. Ray University of Oxford
Charles Swanton
Charles Swanton The Francis Crick Institute
Andrew G. Nicholson
Andrew G. Nicholson Royal Brompton Hospital
Peter H. Howarth
Peter H. Howarth University of Southampton
David H. Dockrell
David H. Dockrell University of Edinburgh
Peter J. M. Openshaw
Peter J. M. Openshaw Imperial College London
David A. Isenberg
David A. Isenberg University College London
Simon S. Cross
Simon S. Cross University of Sheffield

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