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Biology and Biochemistry

D-Index
101
Citations
29931
World Ranking
1475
National Ranking
840

Overview

Shmuel Muallem is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in medicine. Key subfields include molecular biology, physiology, sensory systems, cell biology, and surgery, reflecting a multidisciplinary approach to understanding cellular and molecular mechanisms.

The scientist's work is concentrated on several main topics: ion channels and receptors, ion channel regulation and function, pancreatic function and diabetes, calcium signaling and nucleotide metabolism, cellular transport and secretion, ion transport and channel regulation, as well as phytochemicals and antioxidant activities.

Frequent publication venues for their research include Cell Calcium, Biophysical Journal, The Journal of Cell Biology, Proceedings of the National Academy of Sciences, and The EMBO Journal. These journals are known for their focus on cellular processes, biochemical mechanisms, and physiological functions.

Their recent papers illustrate a focus on calcium channels, lipid signaling, and cellular transport mechanisms:

  • TRPC3 channel gating by lipids requires localization at the ER/PM junctions defined by STIM1, 2022, The Journal of Cell Biology
  • The intracellular Ca2+ channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis, 2022, Proceedings of the National Academy of Sciences
  • PtdSer as a signaling lipid determined by privileged localization of ORP5 and ORP8 at ER/PM junctional foci to determine PM and ER PtdSer/PI(4)P ratio and cell function, 2023, Proceedings of the National Academy of Sciences
  • OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage, 2024, Journal of Clinical Investigation
  • The sun, cholesterol and Orai1 conspire in melanoma, 2022, The EMBO Journal

Collaboration is an important part of their scientific work, with frequent co-authors including Malini Ahuja, Woo Young Chung, Weiyin Lin, Ava Movahed Abtahi, and Spencer R. Leibow. These collaborations have occurred across multiple projects emphasizing the study of ion channels, lipid signaling, and cellular physiology.

Best Publications

  • SOAR and the polybasic STIM1 domains gate and regulate Orai channels

    Joseph P. Yuan;Weizhong Zeng;Michael R. Dorwart;Young Jin Choi

  • STIM1 carboxyl-terminus activates native SOC, I crac and TRPC1 channels

    Guo N. Huang;Weizhong Zeng;Joo Young Kim;Joseph P. Yuan

  • Functional interaction between InsP3 receptors and store-operated Htrp3 channels.

    Kirill Kiselyov;Xin Xu;Galina Mozhayeva;Tuan Kuo

  • Dynamic Association of Proteasomal Machinery with the Centrosome

    W. Christian Wigley;Rosalind P. Fabunmi;Min Goo Lee;Christopher R. Marino

  • Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.

    Joseph P Yuan;Kirill Kiselyov;Dong Ming Shin;Jin Chen

  • STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.

    Joseph P. Yuan;Weizhong Zeng;Guo N. Huang;Paul F. Worley

  • Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis.

    Joo Young Choi;Daniella Muallem;Kirill Kiselyov;Min Goo Lee

  • Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

    Shmuel Muallem;Katarzyna Kwiatkowska;Xin Xu;Helen L. Yin

  • Gating of CFTR by the STAS domain of SLC26 transporters.

    Shigeru B.H. Ko;Weizhong Zeng;Michael R. Dorwart;Xiang Luo

  • Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion

    Min Goo Lee;Ehud Ohana;Ehud Ohana;Ehud Ohana;Hyun Woo Park;Dongki Yang;Dongki Yang;Dongki Yang

  • NaBC1 Is a Ubiquitous Electrogenic Na+-Coupled Borate Transporter Essential for Cellular Boron Homeostasis and Cell Growth and Proliferation

    Meeyoung Park;Qin Li;Nikolay Shcheynikov;Weizong Zeng

  • STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.

    Weizhong Zeng;Joseph P. Yuan;Min Seuk Kim;Young Jin Choi

  • Hormone-evoked calcium release from intracellular stores is a quantal process

    Shmuel Muallem;S. J. Pandol;T. G. Beeker

  • A molecular mechanism for aberrantCFTR-dependent HCO3– transport in cystic fibrosis

    Shigeru B.H. Ko;Nikolay Shcheynikov;Joo Young Choi;Xiang Luo

  • Evolution of calcium homeostasis: From birth of the first cell to an omnipresent signalling system

    R. Maynard Case;David Eisner;Alison Gurney;Owen Jones

  • The N-Terminal Domain of the IP3 Receptor Gates Store-Operated hTrp3 Channels

    Kirill Kiselyov;Gregory A Mignery;Michael X Zhu;Shmuel Muallem

  • Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels.

    D T Yamaguchi;T J Hahn;A Iida-Klein;C R Kleeman

  • Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells CORRELATION WITH INITIATION AND PROPAGATION OF [Ca2+] i WAVES

    Min Goo Lee;Xin Xu;Weizhong Zeng;Julie Diaz

  • RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

    Xin Xu;Weizhong Zeng;Serguei Popov;David M. Berman

  • Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

    Joseph P Yuan;Kirill Kiselyov;Paul F Worley;Shmuel Muallem

Frequent Co-Authors

Min Goo Lee
Min Goo Lee Yonsei University
Philip J. Thomas
Philip J. Thomas The University of Texas Southwestern Medical Center
Paul F. Worley
Paul F. Worley Johns Hopkins University School of Medicine
Stephen J. Pandol
Stephen J. Pandol Cedars-Sinai Medical Center
Sandip Patel
Sandip Patel University College London
Orson W. Moe
Orson W. Moe The University of Texas Southwestern Medical Center
Hidemi Goto
Hidemi Goto Nagoya University
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Gary S. Sachs
Gary S. Sachs Harvard University
Alexei Verkhratsky
Alexei Verkhratsky University of Manchester

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