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D-Index & Metrics

Molecular Biology

D-Index
65
Citations
15678
World Ranking
1668
National Ranking
132

Research.com Recognitions

  • 2004 - Fellow of the Royal Society, United Kingdom

Overview

Dale B. Wigley is affiliated with Imperial College London in the United Kingdom. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions in several interconnected subfields. These include molecular biology, ecology, genetics, surgery, and endocrinology, diabetes, and metabolism.

The scientist's published work addresses a range of topics including DNA repair mechanisms, bacteriophages and microbial interactions, genomics and chromatin dynamics, bacterial genetics and biotechnology, pancreatic function and diabetes, diet, metabolism, and disease, as well as RNA and protein synthesis mechanisms.

Frequent co-authors in their research efforts are Kaiying Cheng, Martin Wilkinson, Adam S. B. Jalal, Paul Girvan, and Elizabeth A. McCormack.

The typical venues for publication reflect a focus on molecular and cellular biology and related fields, appearing in journals such as bioRxiv (Cold Spring Harbor Laboratory), Nature Structural & Molecular Biology, eLife, Molecular Metabolism, and Molecular Cell.

Recent papers authored or co-authored by Wigley include:

  • A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair, 2020, Nature Structural & Molecular Biology
  • Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub, 2022, eLife
  • The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis, 2020, Molecular Metabolism
  • Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex, 2024, Molecular Cell
  • Nucleosome flipping drives kinetic proofreading and processivity by SWR1, 2024, Nature

Wigley was recognized as a Fellow of the Royal Society, United Kingdom, in 2004.

Best Publications

  • Structure and mechanism of helicases and nucleic acid translocases.

    Martin R Singleton;Mark S Dillingham;Dale B Wigley

  • Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.

    Sameer S Velankar;Panos Soultanas;Mark S Dillingham;Hosahalli S Subramanya

  • Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

    Dale B. Wigley;Gideon J. Davies;Eleanor J. Dodson;Anthony Maxwell

  • Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides.

    Martin R Singleton;Michael R Sawaya;Tom Ellenberger;Dale B Wigley

  • Crystal structure of a DExx box DNA helicase.

    Hosahalli S. Subramanya;Louise E. Bird;James A. Brannigan;Dale B. Wigley

  • Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

    Martin R. Singleton;Mark S. Dillingham;Martin Gaudier;Stephen C. Kowalczykowski

  • THE NATURE OF INHIBITION OF DNA GYRASE BY THE COUMARINS AND THE CYCLOTHIALIDINES REVEALED BY X-RAY CRYSTALLOGRAPHY

    R. J. Lewis;O. M. P. Singh;C. V. Smith;T. Skarzynski

  • The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.

    Jeremy P. Derrick;Dale B. Wigley

  • Structural Analysis of DNA Replication Fork Reversal by RecG

    Martin R. Singleton;Sarah Scaife;Dale B. Wigley

  • Crystal Structure of an ATP-Dependent DNA Ligase from Bacteriophage T7

    Hosahalli S. Subramanya;Aidan J. Doherty;Stephen R. Ashford;Dale B. Wigley

  • X-Ray Crystallography Reveals a Large Conformational Change during Guanyl Transfer by mRNA Capping Enzymes

    Kjell Håkansson;Aidan J. Doherty;Stewart Shuman;Dale B. Wigley

  • Structure of the single-strand annealing domain of human RAD52 protein

    Martin R. Singleton;Lois M. Wentzell;Yilun Liu;Stephen C. West

  • Modularity and specialization in superfamily 1 and 2 helicases.

    Martin R. Singleton;Dale B. Wigley

  • Crystal structure of the site-specific recombinase, XerD

    Hosahalli S. Subramanya;Lidia K. Arciszewska;Rachel A. Baker;Louise E. Bird

  • Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed.

    Mark S. Dillingham;Dale B. Wigley;Martin R. Webb

  • High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation.

    Douglas H. Juers;Raymond H. Jacobson;Dale Wigley;Xue‐Jun Zhang

  • Crystal structure of a streptococcal protein G domain bound to an Fab fragment.

    Jeremy P. Derrick;Dale B. Wigley

  • DNA ligases in the repair and replication of DNA.

    David J Timson;Martin R Singleton;Dale B Wigley

  • Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis

    Anthony R. Clarke;Dale B. Wigley;William N. Chia;David Barstow

  • Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase

    Mark S Dillingham;D B Wigley;M R Webb

Frequent Co-Authors

Mark S. Dillingham
Mark S. Dillingham University of Bristol
J. John Holbrook
J. John Holbrook University of Bristol
Anthony R. Clarke
Anthony R. Clarke University of Bristol
Xiaodong Zhang
Xiaodong Zhang Imperial College London
Anthony Maxwell
Anthony Maxwell John Innes Centre
Eleanor J. Dodson
Eleanor J. Dodson University of York
Keith S. Wilson
Keith S. Wilson University of York
Gideon J. Davies
Gideon J. Davies University of York
David J. Sherratt
David J. Sherratt University of Oxford
Stephen C. Kowalczykowski
Stephen C. Kowalczykowski University of California, Davis

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