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Chemistry

D-Index
50
Citations
7406
World Ranking
14560
National Ranking
813

Overview

J. John Holbrook is a researcher affiliated with the University of Bristol in the United Kingdom.

The data available does not list specific research papers, making it difficult to provide details on individual studies or publication history. Similarly, no information on frequent co-authors or publication venues is provided.

Holbrook's areas of scholarly focus and research topics are not explicitly documented in the available data.

No information is given regarding book publications or awards received by Holbrook.

The profile reflects the information currently accessible about this academic researcher without extended narrative on research contributions or career milestones due to limited data.

Best Publications

  • A Specific, Highly Active Malate Dehydrogenase by Redesign of a Lactate Dehydrogenase Framework

    Helen M. Wilks;Keith W. Hart;Raymond Feeney;Cameron R. Dunn

  • Equilibrium binding of nicotinamide nucleotides to lactate dehydrogenases.

    Robert A. Stinson;J. John Holbrook

  • Binding and hydrolysis of nucleotides in the chaperonin catalytic cycle: Implications for the mechanism of assisted protein folding

    Graham S. Jackson;Rosemary A. Staniforth;David J. Halsall;Tony Atkinson

  • Ethidium Bromide as a Cooperative Effector of a DNA Structure

    Fritz M. Pohl;Thomas M. Jovin;W. Baehr;J. J. Holbrook

  • Ionic properties of an essential histidine residue in pig heart lactate dehydrogenase

    J. John Holbrook;V. Ann Ingram

  • Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis

    Anthony R. Clarke;Dale B. Wigley;William N. Chia;David Barstow

  • The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design.

    C R Dunn;M J Banfield;J J Barker;C W Higham

  • Binding of a chaperonin to the folding intermediates of lactate dehydrogenase

    Ian G. Badcoe;Corinne J. Smith;Steven Wood;David J. Halsall

  • Design and synthesis of new enzymes based on the lactate dehydrogenase framework

    CR Dunn;HM Wilks;DJ Halsall;T Atkinson

  • Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution.

    Dale B. Wigley;Steven J. Gamblin;Johan P. Turkenburg;Eleanor J. Dodson

  • From analysis to synthesis: new ligand binding sites on the lactate dehydrogenase framework. Part I

    Anthony R. Clarke;Tony Atkinson;J.John Holbrook

  • Role of solvent reorganization energies in the catalytic activity of enzymes

    Arpita Yadav;Richard M. Jackson;J. John Holbrook;Arieh Warshel

  • Designs for a broad substrate specificity keto acid dehydrogenase.

    Helen M. Wilks;David J. Halsall;Tony Atkinson;William N. Chia

  • Approaches to the study of enzyme mechanisms lactate dehydrogenase

    J.J. Holbrook;H. Gutfreund

  • The multiple complexes formed by the interaction of platelet factor 4 with heparin.

    P E Bock;M Luscombe;S E Marshall;D S Pepper

  • An investigation of the contribution made by the carboxylate group of an active site histidine-aspartate couple to binding and catalysis in lactate dehydrogenase.

    Anthony R. Clarke;Helen M. Wilks;David A. Barstow;Tony Atkinson

  • Cloning, expression and complete nucleotide sequence of the Bacillus stearothermophilus L-lactate dehydrogenase gene.

    Barstow Da;Clarke Ar;Clarke Ar;Chia Wn;Chia Wn;Wigley D;Wigley D

  • A single amino acid substitution in lactate dehydrogenase improves the catalytic efficiency with an alternative coenzyme.

    Raymond Feeney;Anthony R. Clarke;J.John Holbrook

  • The stability and hydrophobicity of cytosolic and mitochondrial malate dehydrogenases and their relation to chaperonin‐assisted folding

    Rosemary A. Staniforth;Antonio Cortés;Steven G. Burston;Tony Atkinson

  • NAD(+)-dependent D-2-hydroxyisocaproate dehydrogenase of Lactobacillus delbrueckii subsp. bulgaricus. Gene cloning and enzyme characterization.

    Nathalie Bernard;Keyji Johnsen;Thierry Ferain;Dominique Garmyn

  • Design of a specific phenyllactate dehydrogenase by peptide loop exchange on the Bacillus stearothermophilus lactate dehydrogenase framework

    Helen M. Wilks;Kathleen M. Moreton;David J. Halsall;Keith W. Hart

Frequent Co-Authors

Anthony R. Clarke
Anthony R. Clarke University of Bristol
Richard B. Sessions
Richard B. Sessions University of Bristol
Dale B. Wigley
Dale B. Wigley Imperial College London
William Chia
William Chia National University of Singapore
Timothy R. Dafforn
Timothy R. Dafforn University of Birmingham
Paul E. Bock
Paul E. Bock Vanderbilt University
James D. Friesen
James D. Friesen University of Toronto
Wim G. J. Hol
Wim G. J. Hol University of Washington
Bruce A. Roe
Bruce A. Roe University of Oklahoma
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute

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Best Scientists Citing J. John Holbrook