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Antony M. Dean

Antony M. Dean

University of Minnesota
United States

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Genetics

Antony M. Dean spends much of his time researching Genetics, Phylogenetics, Gene, Isocitrate dehydrogenase and Biochemistry. His study in the field of Mutation, Nonsynonymous substitution and Plant defense against herbivory is also linked to topics like Pattern recognition receptor. The Phylogenetics study which covers Evolutionary biology that intersects with Amino acid, Mutagenesis and Biological evolution.

His study in Isocitrate dehydrogenase is interdisciplinary in nature, drawing from both IDH1 and Active site. His studies in Active site integrate themes in fields like Stereochemistry, Allosteric regulation and Binding site. Antony M. Dean undertakes multidisciplinary studies into Biochemistry and Nicotinamide adenine dinucleotide phosphate in his work.

His most cited work include:

  • Local migration promotes competitive restraint in a host–pathogen 'tragedy of the commons' (311 citations)
  • Mechanistic approaches to the study of evolution: The functional synthesis (292 citations)
  • Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. (290 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Genetics, Biochemistry, Isocitrate dehydrogenase, Evolutionary biology and Enzyme. The Genetics study combines topics in areas such as Flux and Natural selection. His study in Dehydrogenase, Cofactor, NAD+ kinase, Enzyme kinetics and Mutant is done as part of Biochemistry.

His Isocitrate dehydrogenase study incorporates themes from IDH1, Active site, Stereochemistry, Phosphorylation and Binding site. Within one scientific family, he focuses on topics pertaining to Amino acid under Stereochemistry, and may sometimes address concerns connected to Protein structure. His work carried out in the field of Evolutionary biology brings together such families of science as Adaptation, Molecular evolution, Gene duplication and Common ancestry.

He most often published in these fields:

  • Genetics (43.56%)
  • Biochemistry (49.50%)
  • Isocitrate dehydrogenase (37.62%)

What were the highlights of his more recent work (between 2011-2021)?

  • Evolutionary biology (21.78%)
  • Genetics (43.56%)
  • Ecology (16.83%)

In recent papers he was focusing on the following fields of study:

His main research concerns Evolutionary biology, Genetics, Ecology, Statistical physics and Fitness landscape. In his work, Directed evolution and Molecular evolution is strongly intertwined with Gene duplication, which is a subfield of Evolutionary biology. His study on Genetics is mostly dedicated to connecting different topics, such as Population size.

His work in the fields of Ecology, such as Carrying capacity, overlaps with other areas such as Variable and Mode. His work carried out in the field of Active site brings together such families of science as Amino acid and Isocitrate dehydrogenase. Antony M. Dean combines subjects such as Biochemistry and Enzyme with his study of Promiscuity.

Between 2011 and 2021, his most popular works were:

  • Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases. (54 citations)
  • Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases. (54 citations)
  • Bounded population sizes, fluctuating selection and the tempo and mode of coexistence (41 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Ecology, Genetics, Reaction type, Promiscuity and Lyase. His Coexistence theory and Carrying capacity study, which is part of a larger body of work in Ecology, is frequently linked to Bounded function, Statistical physics and Mode, bridging the gap between disciplines. As part of his studies on Genetics, Antony M. Dean often connects relevant subjects like Population genetics.

There are a combination of areas like Catalytic triad, Biochemistry, Enzyme, Esterase and Catalysis integrated together with his Reaction type study. Promiscuity is closely attributed to myr in his research.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Local migration promotes competitive restraint in a host–pathogen 'tragedy of the commons'

.
Nature (2006)

400 Citations

Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution.

J. G. Bishop;A. M. Dean;T. Mitchell-Olds.
Proceedings of the National Academy of Sciences of the United States of America (2000)

399 Citations

Mechanistic approaches to the study of evolution: The functional synthesis

Antony M. Dean;Joseph W. Thornton.
Nature Reviews Genetics (2007)

378 Citations

The structural basis of molecular adaptation.

G B Golding;A M Dean;A M Dean.
Molecular Biology and Evolution (1998)

327 Citations

Regulation of an enzyme by phosphorylation at the active site

James H. Hurley;Antony M Dean;Antony M Dean;Julie L. Sohl;Daniel E. Koshland.
Science (1991)

318 Citations

Limits of adaptation: the evolution of selective neutrality.

Daniel L. Hartl;Daniel E. Dykhuizen;Antony M. Dean.
Genetics (1985)

302 Citations

Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.

James H. Hurley;Antony M. Dean;Daniel E. Koshland;Robert M. Stroud.
Biochemistry (1991)

298 Citations

The biochemical architecture of an ancient adaptive landscape.

Mark Lunzer;Stephen P. Miller;Roderick Felsheim;Antony M. Dean.
Science (2005)

283 Citations

Metabolic flux and fitness.

Daniel E. Dykhuizen;Antony M. Dean;Daniel L. Hartl.
Genetics (1987)

282 Citations

The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the Products

Daniel M. Stoebel;Antony M. Dean;Daniel E. Dykhuizen.
Genetics (2008)

229 Citations

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