D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics D-index 49 Citations 10,827 80 World Ranking 3221 National Ranking 1403

Research.com Recognitions

Awards & Achievements

2014 - Fellow of John Simon Guggenheim Memorial Foundation

2006 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

Joseph W. Thornton focuses on Evolutionary biology, Phylogenetics, Molecular evolution, Receptor and Phylogenetic tree. In general Evolutionary biology, his work in Function is often linked to Functional synthesis linking many areas of study. His research integrates issues of Gene duplication, Peptide sequence, Sequence alignment and Vertebrate in his study of Phylogenetics.

He works mostly in the field of Molecular evolution, limiting it down to concerns involving Protein structure and, occasionally, Epistasis. His work carried out in the field of Receptor brings together such families of science as Endocrinology and Steroidogenic factor 1. His work on Nuclear receptor and Genome as part of general Genetics research is frequently linked to GPR18, thereby connecting diverse disciplines of science.

His most cited work include:

  • Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling (529 citations)
  • Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions (501 citations)
  • Evolution of Hormone-Receptor Complexity by Molecular Exploitation (469 citations)

What are the main themes of his work throughout his whole career to date?

Joseph W. Thornton mainly investigates Evolutionary biology, Genetics, Gene, Molecular evolution and Phylogenetics. His research in Evolutionary biology intersects with topics in Epistasis, Sequence, Genomics and Phylogenetic tree. His Genetics study frequently draws parallels with other fields, such as Protein structure.

The concepts of his Protein structure study are interwoven with issues in Mutation, Structural biology and Sequence alignment. His Transcription factor research focuses on Receptor and how it connects with Hormone, Endocrinology and Gene expression. His studies in Multiprotein complex integrate themes in fields like Mutagenesis and Molecular machine.

He most often published in these fields:

  • Evolutionary biology (63.64%)
  • Genetics (65.66%)
  • Gene (32.32%)

What were the highlights of his more recent work (between 2017-2021)?

  • Evolutionary biology (63.64%)
  • Phylogenetic tree (23.23%)
  • Gene (32.32%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Evolutionary biology, Phylogenetic tree, Gene, Contingency and Sequence. His Evolutionary biology research includes elements of Homeobox, Phylogenetics, Molecular evolution, Drosophila embryogenesis and Allosteric regulation. His studies deal with areas such as Lineage and Genetic variation as well as Molecular evolution.

His Allosteric regulation research includes themes of Gene duplication, Protein structure, Protein subunit and Cooperativity. Joseph W. Thornton has included themes like Positive selection and Fixation in his Phylogenetic tree study. His research on Gene concerns the broader Genetics.

Between 2017 and 2021, his most popular works were:

  • Multinucleotide mutations cause false inferences of lineage-specific positive selection. (74 citations)
  • Pervasive contingency and entrenchment in a billion years of Hsp90 evolution. (44 citations)
  • Origin of complexity in haemoglobin evolution (19 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Genetics

The scientist’s investigation covers issues in Evolutionary biology, Gene, Allosteric regulation, Molecular evolution and Phylogenetic tree. The Evolutionary biology study combines topics in areas such as Protein structure, Heterotetramer and Phylogenetics. His Gene research incorporates elements of Biophysics, Function and Structural bioinformatics.

His biological study spans a wide range of topics, including Cooperativity, Natural selection, Protein subunit, Negative selection and Gene duplication. His Molecular evolution study combines topics from a wide range of disciplines, such as Positive selection, Fixation, Population genetics and Human evolutionary genetics. His Phylogenetic tree research is multidisciplinary, incorporating elements of Homeobox, Transcription factor, Evolutionary developmental biology and Drosophila embryogenesis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

Joseph W. Thornton;Joseph W. Thornton;Eleanor Need;Eleanor Need;David P Crews;David P Crews.
Science (2003)

730 Citations

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

Joseph W. Thornton.
Proceedings of the National Academy of Sciences of the United States of America (2001)

694 Citations

Evolution of Hormone-Receptor Complexity by Molecular Exploitation

Jamie T. Bridgham;Sean M. Carroll;Joseph W. Thornton.
Science (2006)

646 Citations

Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous

Bryan Kolaczkowski;Joseph W. Thornton.
Nature (2004)

628 Citations

Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts.

Mary Beth Hawkins;Joseph W. Thornton;David P Crews;James K. Skipper.
Proceedings of the National Academy of Sciences of the United States of America (2000)

591 Citations

Crystal structure of an ancient protein: evolution by conformational epistasis.

Eric A. Ortlund;Jamie T. Bridgham;Matthew R. Redinbo;Joseph W. Thornton.
Science (2007)

471 Citations

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Irina N. Krylova;Elena P. Sablin;Jamie Moore;Robert X. Xu.
Cell (2005)

461 Citations

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

Jamie T. Bridgham;Eric A. Ortlund;Joseph W. Thornton.
Nature (2009)

425 Citations

Resurrecting ancient genes: experimental analysis of extinct molecules

Joseph W. Thornton.
Nature Reviews Genetics (2004)

405 Citations

Mechanistic approaches to the study of evolution: The functional synthesis

Antony M. Dean;Joseph W. Thornton.
Nature Reviews Genetics (2007)

378 Citations

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