Joseph W. Thornton

Research.com Recognitions

• 2014 - Fellow of John Simon Guggenheim Memorial Foundation
• 2006 - Fellow of Alfred P. Sloan Foundation

Overview

Best Publications

• Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

  Joseph W. Thornton;Joseph W. Thornton;Eleanor Need;Eleanor Need;David P Crews;David P Crews

  782
  Citations

• Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

  Joseph W. Thornton

  739
  Citations

• Evolution of Hormone-Receptor Complexity by Molecular Exploitation

  Jamie T. Bridgham;Sean M. Carroll;Joseph W. Thornton

  705
  Citations

• Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous

  Bryan Kolaczkowski;Joseph W. Thornton

  687
  Citations

• Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts.

  Mary Beth Hawkins;Joseph W. Thornton;David P Crews;James K. Skipper

  604
  Citations

• Epistasis in protein evolution

  Tyler N. Starr;Joseph W. Thornton

  523
  Citations

• Crystal structure of an ancient protein: evolution by conformational epistasis.

  Eric A. Ortlund;Jamie T. Bridgham;Matthew R. Redinbo;Joseph W. Thornton

  512
  Citations

• Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

  Irina N. Krylova;Elena P. Sablin;Jamie Moore;Robert X. Xu

  492
  Citations

• An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

  Jamie T. Bridgham;Eric A. Ortlund;Joseph W. Thornton

  464
  Citations

• Resurrecting ancient genes: experimental analysis of extinct molecules

  Joseph W. Thornton

  440
  Citations

• Mechanistic approaches to the study of evolution: The functional synthesis

  Antony M. Dean;Joseph W. Thornton

  398
  Citations

• Evolutionary biochemistry: revealing the historical and physical causes of protein properties

  Michael J. Harms;Joseph W. Thornton;Joseph W. Thornton

  389
  Citations

• Gene Family Evolution and Homology: Genomics Meets Phylogenetics

  Joseph W. Thornton;Rob DeSalle

  283
  Citations

• Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.

  Jamie T. Bridgham;Geeta N. Eick;Claire Larroux;Kirti Deshpande

  254
  Citations

• Analyzing protein structure and function using ancestral gene reconstruction.

  Michael J Harms;Joseph W Thornton

  254
  Citations

• The interface of protein structure, protein biophysics, and molecular evolution.

  David A Liberles;Sarah A Teichmann;Ivet Bahar;Ugo Bastolla

  252
  Citations

• Evolution of increased complexity in a molecular machine

  Gregory C. Finnigan;Victor Hanson-Smith;Tom H. Stevens;Joseph W. Thornton;Joseph W. Thornton;Joseph W. Thornton

  248
  Citations

• The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications.

  June Keay;Jamie T. Bridgham;Joseph W. Thornton

  231
  Citations

• Alternative evolutionary histories in the sequence space of an ancient protein

  Tyler N. Starr;Lora K. Picton;Joseph W. Thornton

  209
  Citations

• Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty

  Victor Hanson-Smith;Bryan Kolaczkowski;Joseph W. Thornton;Joseph W. Thornton

  200
  Citations