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Chemistry

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56
Citations
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World Ranking
11714
National Ranking
661

Biology and Biochemistry

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Overview

Timothy R. Dafforn is a researcher affiliated with the University of Birmingham in the United Kingdom. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with notable activity in Medicine.

Their research touches on several subfields, including Molecular Biology, Infectious Diseases, Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, and Ecology.

Key topics within their research portfolio include:

  • Lipid Membrane Structure and Behavior
  • Monoclonal and Polyclonal Antibodies Research
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms
  • Biosensors and Analytical Detection
  • Receptor Mechanisms and Signaling
  • SARS-CoV-2 detection and testing

Timothy R. Dafforn has contributed to a variety of scientific publications with particular engagement in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Biomacromolecules
  • Archives of Biochemistry and Biophysics
  • Journal of Colloid and Interface Science

Some of the recent publications featuring their work include:

  • Ultrarapid detection of SARS-CoV-2 RNA using a reverse transcription-free exponential amplification reaction, RTF-EXPAR, 2021, Proceedings of the National Academy of Sciences
  • Ligand-induced conformational changes in a SMALP-encapsulated GPCR., 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Improvements in the production of purified M13 bacteriophage bio-nanoparticle, 2020, Scientific Reports
  • Determination and characterisation of the surface charge properties of the bacteriophage M13 to assist bio-nanoengineering, 2020, RSC Advances
  • Influence of DIBMA Polymer Length on Lipid Nanodisc Formation and Membrane Protein Extraction, 2020, Biomacromolecules

The frequent coauthors collaborating with Timothy R. Dafforn are:

  • James H. R. Tucker
  • Jake G. Carter
  • Bert Klumperman
  • Naomi L. Pollock
  • Thomas Arnold

Best Publications

  • Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer.

    Timothy J. Knowles;Rachael Finka;Corinne Smith;Yu-Pin Lin

  • A method for detergent-free isolation of membrane proteins in their local lipid environment

    Sarah C Lee;Tim J Knowles;Vincent L G Postis;Vincent L G Postis;Mohammed Jamshad

  • Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: the power of native nanodiscs.

    Jonas M. Dörr;Martijn C. Koorengevel;Marre Schäfer;Alexander V. Prokofyev

  • A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain

    David J. Owen;Yvonne Vallis;Martin E.M. Noble;Jack B. Hunter

  • Linear Dichroism and Circular Dichroism: A Textbook on Polarized-Light Spectroscopy

    Bengt Nordén;Alison Rodger;Tim Dafforn

  • Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

    Thomas H Millard;Guillaume Bompard;Man Yeung Heung;Timothy R Dafforn

  • Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

    Tomas Laursen;Jonas Borch;Camilla Knudsen;Krutika Bavishi

  • A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

    Timothy R. Dafforn;Ravi Mahadeva;Peter R. Elliott;Pasupathy Sivasothy

  • Detergent-free purification of ABC (ATP-binding-cassette) transporters

    Sonali Gulati;Mohammed Jamshad;Timothy J Knowles;Kerrie A Morrison

  • Topography of a 2.0 A Structure of Alpha1-Antitrypsin Reveals Targets for Rational Drug Design to Prevent Conformational Disease.

    Peter R. Elliott;Xue Y. Pei;Timothy R. Dafforn;David A. Lomas

  • Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins.

    Mohammed Jamshad;Vinciane Grimard;Ilaria Idini;Timothy J. Knowles

  • G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

    Mohammed Jamshad;Jack Charlton;Yu-Pin Lin;Sarah J Routledge

  • Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

    Bibek Gooptu;Bart Hazes;Wun-Shaing W. Chang;Timothy R. Dafforn

  • The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy

    Vincent Postis;Shaun Rawson;Jennifer K. Mitchell;Sarah C. Lee

  • Heteropolymerization of S, I, and Z α1-antitrypsin and liver cirrhosis

    Ravi Mahadeva;Wun-Shaing W. Chang;Timothy R. Dafforn;Diana J. Oakley

  • 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.

    Ravi Mahadeva;Timothy R. Dafforn;Robin W. Carrell;David A. Lomas

  • Pathogenic α1-Antitrypsin Polymers are Formed by Reactive Loop-β-Sheet a Linkage

    P Sivasothy;TD Dafforn;Pwg Gettins;DA Lomas

  • The Molecular Interactions of Heat Shock Protein 47 (Hsp47) and Their Implications for Collagen Biosynthesis

    Timothy R. Dafforn;Marina Della;Andrew D. Miller

  • Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody.

    Peter A. Smethurst;Lotta Joutsi-Korhonen;Marie N. O'Connor;Erica Wilson

  • Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure.

    Kerrie A. Morrison;Aneel Akram;Ashlyn Mathews;Zoeya A. Khan

  • Linear Dichroism and Circular Dichroism

    Bengt Nordén;Alison Rodger;Tim Dafforn

Frequent Co-Authors

Alison Rodger
Alison Rodger Macquarie University
David A. Lomas
David A. Lomas University College London
Michael Overduin
Michael Overduin University of Alberta
Robin W. Carrell
Robin W. Carrell University of Cambridge
Robert A. Stockley
Robert A. Stockley University of Birmingham
Louise C. Serpell
Louise C. Serpell University of Sussex
Roslyn M. Bill
Roslyn M. Bill Aston University
Karen J. Edler
Karen J. Edler University of Bath
Richard B. Sessions
Richard B. Sessions University of Bristol
David R. Poyner
David R. Poyner Aston University

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