Stephen P. Bottomley

Overview

Best Publications

• A Common Fold Mediates Vertebrate Defense and Bacterial Attack

  Carlos J. Rosado;Ashley M. Buckle;Ruby H. P. Law;Rebecca E. Butcher;Rebecca E. Butcher

  335
  Citations

• Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

  Roberto Cappai;Su-Ling Leck;Deborah J Tew;Deborah J Tew;Nicholas A Williamson

  320
  Citations

• MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

  Brett Verstak;Kamalpreet Nagpal;Stephen Paul Bottomley;Douglas T Golenbock

  277
  Citations

• Functional insights from the distribution and role of homopeptide repeat-containing proteins.

  Noel Garry Faux;Stephen Paul Bottomley;Arthur M Lesk;James Alexander Irving

  237
  Citations

• The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

  Andrew Malcolm Ellisdon;Bronwen Thomas;Stephen Paul Bottomley

  217
  Citations

• Antithrombin: in control of coagulation.

  Noelene Sheila Quinsey;Ainsley L Greedy;Stephen Paul Bottomley;James C Whisstock

  213
  Citations

• A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production.

  Lisa D Cabrita;Weiwen Dai;Stephen Paul Bottomley

  210
  Citations

• Molecular gymnastics: serpin structure, folding and misfolding

  James Whisstock;Stephen Paul Bottomley

  194
  Citations

• Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion.

  Danielle Zernich;Anthony W Purcell;Whitney A Macdonald;Lars Kjer-Nielsen

  194
  Citations

• Enhancing the stability and solubility of TEV protease using in silico design.

  Lisa Cabrita;Dimitri Gilis;Amy Louise Robertson;Yves Dehouck

  181
  Citations

• Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.

  Gary A Silverman;James C Whisstock;Stephen Paul Bottomley;James A Huntington

  164
  Citations

• Protein expression and refolding - a practical guide to getting the most out of inclusion bodies

  Lisa D Cabrita;Stephen P Bottomley

  153
  Citations

• Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

  Travis Clarke Beddoe;Zhenjun Chen;Craig Steven Clements;Lauren Kate Ely

  148
  Citations

• Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency.

  Glyn L. Devlin;Helen Parfrey;Deborah J. Tew;David A. Lomas

  130
  Citations

• Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer's Disease Amyloid-β Peptide

  Deborah J Tew;Deborah J Tew;Stephen Paul Bottomley;David P Smith;David P Smith;Giuseppe Ciccotosto;Giuseppe Ciccotosto

  125
  Citations

• Serpins Flex Their Muscle II. STRUCTURAL INSIGHTS INTO TARGET PEPTIDASE RECOGNITION, POLYMERIZATION, AND TRANSPORT FUNCTIONS

  James C Whisstock;Gary A Silverman;Phillip Ian Bird;Stephen Paul Bottomley

  125
  Citations

• The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins.

  Anita Julieanne Horvath;James Alexander Irving;James Alexander Irving;Jamie Rossjohn;Jamie Rossjohn;Ruby H P Law;Ruby H P Law

  124
  Citations

• The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G.

  Fiona L. Scott;Claire E. Hirst;Jiuru Sun;Catherina H. Bird

  123
  Citations

• The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

  Ruth M. Kennan;Ruth M. Kennan;Wilson Wong;Wilson Wong;Om P. Dhungyel;Xiaoyan Han;Xiaoyan Han

  111
  Citations

• The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance

  Andrew Ian Webb;Natalie A Borg;Michelle Anne Dunstone;Lars Kjer-Nielsen

  28
  Citations