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Molecular Biology

D-Index
64
Citations
14838
World Ranking
1740
National Ranking
874

Overview

Ruth Lupu is affiliated with the Mayo Clinic in the United States, where they contribute to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their scientific work is concentrated on cancer biology, with a strong focus on cancer research and molecular biology. Oncology, pulmonary and respiratory medicine, and pharmacology also form part of their research scope.

The main topics addressed in Ruth Lupu's work include:

  • Cancer, Lipids, and Metabolism
  • Cancer, Hypoxia, and Metabolism
  • Peroxisome Proliferator-Activated Receptors
  • Lung Cancer Treatments and Mutations
  • Cancer Immunotherapy and Biomarkers
  • RNA modifications and cancer
  • HER2/EGFR in Cancer Research

Ruth Lupu has co-authored numerous papers with several frequently collaborating researchers, notably:

  • Javier A. Menéndez (16 publications)
  • Elisabet Cuyàs (15 publications)
  • Sara Verdura (15 publications)
  • Travis Vander Steen (9 publications)
  • Begoña Martı́n-Castillo (6 publications)

Their research is regularly published in journals such as:

  • Cancers (3 publications)
  • Annals of Oncology (3 publications)
  • Cell Death Discovery (2 publications)
  • Expert Opinion on Therapeutic Targets (2 publications)
  • International Journal of Molecular Sciences (2 publications)

Some of Ruth Lupu's recent papers include:

  • Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells, 2021, Cell Death and Disease
  • Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer, 2021, Cancers
  • Fatty acid synthase: a druggable driver of breast cancer brain metastasis, 2022, Expert Opinion on Therapeutic Targets
  • Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer, 2020, International Journal of Molecular Sciences
  • Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy, 2020, Cancers

Best Publications

  • Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

    Fei Wang;Valerie M. Weaver;Ole W. Petersen;Carolyn A. Larabell

  • Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

    Ruth Lupu;Ramon Colomer;Gerhard Zugmaier;Jay Sarup

  • Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin™) in breast cancer cells with Her-2/neu oncogene amplification

    J. A. Menendez;L. Vellon;R. Colomer;R. Lupu;R. Lupu

  • Expression and regulation of estrogen receptor beta in human breast tumors and cell lines.

    Unknown

  • Expression of Estrogen Receptor β Messenger RNA Variant in Breast Cancer

    Unknown

  • Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells.

    A. Vazquez-Martin;R. Colomer;J. Brunet;R. Lupu

  • Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

    Ruth Lupu;Javier A Menendez;Javier A Menendez

  • Antibody‐induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c‐erbb‐2 (her‐2/neu) gene product p185

    Fengji Xu;Ruth Lupu;Gustavo C. Rodriguez;Regina S. Whitaker

  • Involvement of Heregulin-β2 in the Acquisition of the Hormone-independent Phenotype of Breast Cancer Cells

    Unknown

  • Transforming Growth Factor β1 Induces Cachexia and Systemic Fibrosis without an Antitumor Effect in Nude Mice

    Gerhard Zugmaier;Soonmyoung Paik;George Wilding;Cornelius Knabbe

  • A genomic explanation connecting “Mediterranean diet”, olive oil and cancer: Oleic acid, the main monounsaturated Fatty acid of olive oil, induces formation of inhibitory “PEA3 transcription factor-PEA3 DNA binding site” complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells

    Javier A. Menendez;Adriana Papadimitropoulou;Adriana Papadimitropoulou;Luciano Vellon;Luciano Vellon;Ruth Lupu;Ruth Lupu

  • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    Javier A. Menendez;Luciano Vellon;Luciano Vellon;Ramon Colomer;Ruth Lupu;Ruth Lupu

  • The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives.

    J A Menéndez;I Mehmi;D W Griggs;R Lupu

  • Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

    Ruth Lupu;Ramon Colomer;Bhanu Kannan;Marc E. Lippman

  • Neu Differentiation Factor (Heregulin) Induces Expression of Intercellular Adhesion Molecule 1: Implications for Mammary Tumors

    Sarah S. Bacus;Andrei V. Gudkov;Carolyn R. Zelnick;Dot Chin

  • erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification.

    R. Colomer;R. Lupu;S. S. Bacus;E. P. Gelmann

  • A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells

    Sarah S. Bacus;Eliezer Huberman;Dot Chin;Kaoru Kiguchi

  • Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9)

    Javier A Menendez;Ruth Lupu

  • Increased miR-708 Expression in NSCLC and Its Association with Poor Survival in Lung Adenocarcinoma from Never Smokers

    Jin Sung Jang;Hyo Sung Jeon;Zhifu Sun;Marie Christine Aubry

  • Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.

    Javier A Menendez;Ruth Lupu

Frequent Co-Authors

Javier A. Menendez
Javier A. Menendez Catalan Institute of Oncology
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Erik W. Thompson
Erik W. Thompson Queensland University of Technology
George Kemble
George Kemble Sagimet Biosciences
María J. Vicent
María J. Vicent Cardiff University
Jorge Joven
Jorge Joven Rovira i Virgili University
Edward B. Leof
Edward B. Leof Mayo Clinic
Marvin C. Gershengorn
Marvin C. Gershengorn National Institutes of Health
Vicente Micol
Vicente Micol Miguel Hernandez University
Walter Berger
Walter Berger Medical University of Vienna

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