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Immunology

D-Index
59
Citations
12161
World Ranking
3430
National Ranking
1593

Overview

George Kemble is affiliated with Sagimet Biosciences in the United States and has an active research profile focused on medicine and biochemistry, genetics, and molecular biology. Their work spans several specialized subfields including cancer research, pulmonary and respiratory medicine, molecular biology, epidemiology, and hepatology.

The main topics of their research encompass the intersection of cancer, lipids, and metabolism, liver disease diagnosis and treatment, cancer under hypoxic conditions, ferroptosis and cancer prognosis, RNA modifications related to cancer, lung cancer treatments and mutations, as well as diet and metabolism studies.

Kemble's recent papers include:

  • "Denifanstat for the treatment of metabolic dysfunction-associated steatohepatitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2b trial," 2024, The 'Lancet. Gastroenterology & hepatology
  • "Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer," 2025, Neoplasia
  • "Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," 2022, Nature Communications
  • "Multicenter, randomized, double-blind, placebo-controlled trial of Fatty Acid Synthase (FASN) inhibitor, denifanstat, versus placebo in the treatment of biopsy-proven NASH: A 26-week interim analysis of the FASCINATE-2 Phase 2B trial," 2023, Journal of Hepatology
  • "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," 2021, bioRxiv (Cold Spring Harbor Laboratory)

The scientist often collaborates with several frequent co-authors, including Rohit Loomba, Katharine Grimmer, Eduardo B. Martins, Marie O'Farrell, and Wen-Wei Tsai. Kemble's work has been published mainly in the Journal of Hepatology, with additional publications in The 'Lancet. Gastroenterology & hepatology, Neoplasia, Nature Communications, and bioRxiv (Cold Spring Harbor Laboratory).

The focus on therapeutic interventions and molecular mechanisms is evident through the research on fatty acid synthase inhibition, metabolic dysfunction-associated steatohepatitis, ferroptosis in KRAS-mutant lung cancer, and mitochondrial apoptosis in pancreatic cancer. The use of clinical trial data further highlights Kemble's involvement in translational biomedical research.

Best Publications

  • Live attenuated versus inactivated influenza vaccine in infants and young children.

    Robert B. Belshe;Kathryn M. Edwards;Timo Vesikari;Steven V. Black

  • Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains.

    Tai-An Cha;E. Tom;G. W. Kemble;G. M. Duke

  • Cytomegalovirus encodes a potent alpha chemokine.

    Mark E. T. Penfold;Daniel J. Dairaghi;Gregory M. Duke;Noah Saederup

  • Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (flumist) derived from cold-adapted a/ann arbor/6/60

    Hong Jin;Bin Lu;Helen Zhou;Chienhui Ma

  • Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines.

    Xiao-Song He;Tyson H. Holmes;Caiqiu Zhang;Kutubuddin Mahmood

  • Glycosylation at 158N of the Hemagglutinin Protein and Receptor Binding Specificity Synergistically Affect the Antigenicity and Immunogenicity of a Live Attenuated H5N1 A/Vietnam/1203/2004 Vaccine Virus in Ferrets

    Weijia Wang;Bin Lu;Helen Zhou;Amorsolo L. Suguitan

  • Live, Attenuated Influenza A H5N1 Candidate Vaccines Provide Broad Cross-Protection in Mice and Ferrets

    Amorsolo L Suguitan;Josephine McAuliffe;Kimberly L Mills;Hong Jin

  • Influence of Prior Influenza Vaccination on Antibody and B-Cell Responses

    Sanae Sasaki;Xiao-Song He;Xiao-Song He;Tyson H. Holmes;Cornelia L. Dekker

  • Rescue of influenza B virus from eight plasmids

    Erich Hoffmann;Kutubuddin Mahmood;Chin-Fen Yang;Robert G. Webster

  • A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation.

    Edward S. Mocarski;George W. Kemble;John M. Lyle;Richard F. Greaves

  • Comparison of the Influenza Virus-Specific Effector and Memory B-Cell Responses to Immunization of Children and Adults with Live Attenuated or Inactivated Influenza Virus Vaccines

    Sanae Sasaki;Maria C. Jaimes;Maria C. Jaimes;Tyson H. Holmes;Cornelia L. Dekker

  • Cytomegalovirus UL97 Phosphotransferase Mutations That Affect Susceptibility to Ganciclovir

    Sunwen Chou;Sunwen Chou;Rachel H. Waldemer;Rachel H. Waldemer;Anne E. Senters;Anne E. Senters;Kevin S. Michels;Kevin S. Michels

  • Persistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children

    Wenwei Tu;Sharon Chen;Margaret Sharp;Corry Dekker

  • A review of genetic differences between limited and extensively passaged human cytomegalovirus strains.

    M. N. Prichard;M. E. T. Penfold;G. M. Duke;R. R. Spaete

  • Generation of Live Attenuated Novel Influenza Virus A/California/7/09 (H1N1) Vaccines with High Yield in Embryonated Chicken Eggs

    Zhongying Chen;Weijia Wang;Helen Zhou;Amorsolo L. Suguitan

  • T cell–dependent production of IFN-γ by NK cells in response to influenza A virus

    Xiao Song He;Monia Draghi;Kutubuddin Mahmood;Tyson H. Holmes

  • Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target.

    Douglas Buckley;Gregory Duke;Timothy S. Heuer;Marie O'Farrell

  • Improvement of Influenza A/Fujian/411/02 (H3N2) Virus Growth in Embryonated Chicken Eggs by Balancing the Hemagglutinin and Neuraminidase Activities, Using Reverse Genetics

    Bin Lu;Helen Zhou;Dan Ye;George Kemble

  • Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults.

    Ruth A. Karron;Kawsar Talaat;Catherine Luke;Karen Callahan

  • Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99.

    Hong Jin;Helen Zhou;Hui Liu;Winnie Chan

  • Defined large-scale alterations of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids.

    G Kemble;G Duke;R Winter;R Spaete

Frequent Co-Authors

Hong Jin
Hong Jin AstraZeneca (United Kingdom)
Harry B. Greenberg
Harry B. Greenberg Stanford University
Kanta Subbarao
Kanta Subbarao University of Melbourne
Ann M. Arvin
Ann M. Arvin Stanford University
Xiao-Song He
Xiao-Song He University of California, Davis
Cornelia L. Dekker
Cornelia L. Dekker Stanford University
Brian R. Murphy
Brian R. Murphy National Institute of Allergy and Infectious Diseases
David E. Swayne
David E. Swayne United States Department of Agriculture
Edward S. Mocarski
Edward S. Mocarski Emory University
Ruth A. Karron
Ruth A. Karron Johns Hopkins University

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