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Mikiko C. Siomi

Mikiko C. Siomi

D-Index & Metrics

Genetics

D-Index
60
Citations
25282
World Ranking
3107
National Ranking
135

Overview

Mikiko C. Siomi is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a significant focus also on agricultural and biological sciences. The researcher's work covers various subfields, including molecular biology, plant science, public health, environmental and occupational health, genetics, and biomaterials.

The main research topics addressed by Mikiko C. Siomi include:

  • Chromosomal and genetic variations
  • CRISPR and genetic engineering
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms
  • Plant virus research studies
  • Animal genetics and reproduction
  • Silk-based biomaterials and applications

Siomi's recent publications span several notable venues and highlight key aspects of RNA biology, particularly within Drosophila and other model organisms:

  • "The piRNA pathway in Drosophila ovarian germ and somatic cells," 2020, Proceedings of the Japan Academy Series B
  • "Crystal structure of Drosophila Piwi," 2020, Nature Communications
  • "piRNA- and siRNA-mediated transcriptional repression in Drosophila, mice, and yeast: new insights and biodiversity," 2021, EMBO Reports
  • "Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation," 2021, Nucleic Acids Research
  • "The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation," 2020, Nature Communications

Mikiko C. Siomi frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • EMBO Reports
  • The EMBO Journal
  • Proceedings of the Japan Academy Series B

Collaborative efforts mark an important dimension of this researcher's career, with frequent co-authors including:

  • Hidenori Nishihara
  • Kazumichi M. Nishida
  • Soichiro Yamanaka
  • Yuka W. Iwasaki
  • Tetsutaro Sumiyoshi

Overall, Mikiko C. Siomi's research contributions focus on molecular mechanisms impacting gene regulation, piRNA pathways, and chromatin remodeling, frequently intersecting with genetic engineering and biosensing technologies. The combination of work within animal and plant systems reflects a broad interdisciplinary approach to molecular biology and genetics.

Best Publications

  • Biogenesis of small RNAs in animals.

    V. Narry Kim;Jinju Han;Mikiko C. Siomi

  • PIWI-interacting small RNAs: the vanguard of genome defence.

    Mikiko C. Siomi;Kaoru Sato;Dubravka Pezic;Alexei A. Aravin

  • A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.

    Lalith S. Gunawardane;Kuniaki Saito;Kazumichi M. Nishida;Keita Miyoshi

  • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

    Katsutomo Okamura;Akira Ishizuka;Haruhiko Siomi;Mikiko C. Siomi

  • On the road to reading the RNA-interference code.

    Haruhiko Siomi;Mikiko C. Siomi

  • A NOVEL RECEPTOR-MEDIATED NUCLEAR PROTEIN IMPORT PATHWAY

    Victoria W Pollard;W.Matthew Michael;Sara Nakielny;Mikiko C Siomi

  • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

    Akira Ishizuka;Mikiko C. Siomi;Haruhiko Siomi

  • Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome

    Kuniaki Saito;Kazumichi M. Nishida;Tomoko Mori;Yoshinori Kawamura

  • Posttranscriptional regulation of microRNA biogenesis in animals.

    Haruhiko Siomi;Mikiko C. Siomi

  • PIWI-Interacting RNA: Its Biogenesis and Functions

    Yuka W. Iwasaki;Mikiko C. Siomi;Haruhiko Siomi

  • Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome.

    Haruhiko Siomi;Mleyoung Choi;Mikiko C. Siomi;Robert L. Nussbaum

  • Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

    Yoshinori Kawamura;Kuniaki Saito;Kuniaki Saito;Taishin Kin;Yukiteru Ono

  • Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

    Kuniaki Saito;Akira Ishizuka;Haruhiko Siomi;Mikiko C Siomi

  • Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi- interacting RNAs at their 3′ ends

    Kuniaki Saito;Yuriko Sakaguchi;Takeo Suzuki;Tsutomu Suzuki

  • Slicer function of Drosophila Argonautes and its involvement in RISC formation

    Keita Miyoshi;Hiroko Tsukumo;Tomoko Nagami;Haruhiko Siomi

  • A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

    Kuniaki Saito;Sachi Inagaki;Toutai Mituyama;Yoshinori Kawamura;Yoshinori Kawamura

  • The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.

    Y Zhang;J P O'Connor;M C Siomi;S Srinivasan

  • Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines

    Hirotsugu Ishizu;Haruhiko Siomi;Mikiko C. Siomi;Mikiko C. Siomi

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila

    Kuniaki Saito;Hirotsugu Ishizu;Miharu Komai;Hazuki Kotani

Frequent Co-Authors

Haruhiko Siomi
Haruhiko Siomi Keio University
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Osamu Nureki
Osamu Nureki University of Tokyo
Kiyoshi Asai
Kiyoshi Asai University of Tokyo
Hideyuki Okano
Hideyuki Okano Keio University
Gideon Dreyfuss
Gideon Dreyfuss University of Pennsylvania
Tohru Natsume
Tohru Natsume National Institute of Advanced Industrial Science and Technology
Norio Ishida
Norio Ishida National Institute of Advanced Industrial Science and Technology
Tatsuhiko Kodama
Tatsuhiko Kodama University of Tokyo

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