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Genetics

D-Index
88
Citations
37699
World Ranking
1150
National Ranking
552

Overview

Eric C. Lai is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology, Cancer Research, Plant Science, Genetics, and Infectious Diseases.

The scientist's work covers several interconnected topics, including:

  • RNA Research and Splicing
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Circular RNAs in diseases
  • Chromosomal and Genetic Variations
  • RNA Interference and Gene Delivery

Eric C. Lai has coauthored numerous publications with several frequent collaborators. Key coauthors include Seungjae Lee with 14 joint publications, Renfu Shang with 12, Jeffrey Vedanayagam with 8, Brian Joseph with 7, and David Jee also with 7 collaborative works.

Their research has been disseminated across multiple high-profile venues, notably including:

  • bioRxiv (Cold Spring Harbor Laboratory) with 18 publications
  • Nature Communications with 5 publications
  • PLoS Genetics with 4 publications
  • Life Science Alliance with 3 publications
  • Molecular Cell with 3 publications

Some of the recent scientific papers by Eric C. Lai include:

  • "microRNAs in action: biogenesis, function and regulation" (2023), published in Nature Reviews Genetics
  • "Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution" (2023), published in Science
  • "A neural m6A/Ythdf pathway is required for learning and memory in Drosophila" (2021), published in Nature Communications
  • "Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision" (2023), published in Nature Methods
  • "Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila" (2020), published in Molecular Cell

Best Publications

  • Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.

    Eric C. Lai

  • Notch signaling: control of cell communication and cell fate

    Eric C. Lai

  • The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila

    Katsutomo Okamura;Joshua W. Hagen;Hong Duan;David M. Tyler

  • Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

    Sushmita Roy;Jason Ernst;Peter V. Kharchenko;Pouya Kheradpour

  • Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

    Mark B. Gerstein;Zhi John Lu;Eric L. Van Nostrand;Chao Cheng

  • Mammalian mirtron genes.

    Eugene Berezikov;Wei Jen Chung;Jason Willis;Edwin Cuppen

  • Computational identification of Drosophila microRNA genes

    Eric C Lai;Pavel Tomancak;Robert W Williams;Gerald M Rubin

  • Unlocking the Secrets of the Genome

    Susan E. Celniker;Laura A. L. Dillon;Mark B. Gerstein;Kristin C. Gunsalus

  • Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

    Jakub O. Westholm;Pedro Miura;Pedro Miura;Sara Olson;Sol Shenker;Sol Shenker

  • Biological principles of microRNA-mediated regulation: shared themes amid diversity

    Alex S. Flynt;Eric C. Lai

  • Diversity and dynamics of the Drosophila transcriptome

    James B. Brown;James B. Brown;Nathan Boley;Robert Eisman;Gemma E. May

  • miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling.

    Alberto Dávalos;Leigh Goedeke;Peter Smibert;Cristina M. Ramírez

  • Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

    Alexander Stark;Michael F Lin;Pouya Kheradpour;Jakob Skou Pedersen;Jakob Skou Pedersen

  • Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs

    J. Graham Ruby;Alexander Stark;Wendy K. Johnston;Manolis Kellis

  • The regulatory activity of microRNA * species has substantial influence on microRNA and 3′ UTR evolution

    Katsutomo Okamura;Michael D Phillips;David M Tyler;Hong Duan

  • Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants

    Jr Shiuan Yang;Eric C. Lai

  • Vive la différence: biogenesis and evolution of microRNAs in plants and animals.

    Michael J Axtell;Jakub O Westholm;Eric C Lai

  • Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs

    Qingfa Wu;Yingjun Luo;Rui Lu;Nelson Lau

  • Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

    Jr.-Shiuan Yang;Thomas Maurin;Nicolas Robine;Kasper D. Rasmussen

  • The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs.

    Katsutomo Okamura;Wei-Jen Chung;J. Graham Ruby;Huili Guo

Frequent Co-Authors

Norbert Perrimon
Norbert Perrimon Harvard University
Susan E. Celniker
Susan E. Celniker Lawrence Berkeley National Laboratory
Adam Siepel
Adam Siepel Cold Spring Harbor Laboratory
James W. Posakony
James W. Posakony University of California, San Diego
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute
Thomas C. Kaufman
Thomas C. Kaufman Indiana University
Thomas R. Gingeras
Thomas R. Gingeras Cold Spring Harbor Laboratory
Brenton R. Graveley
Brenton R. Graveley University of Connecticut Health Center
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Eugene Berezikov
Eugene Berezikov University Medical Center Groningen

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