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Genetics

D-Index
70
Citations
48445
World Ranking
2227
National Ranking
1002

Research.com Recognitions

  • 2012 - Fellow of John Simon Guggenheim Memorial Foundation
  • 2009 - Fellow of Alfred P. Sloan Foundation

Overview

Adam Siepel is affiliated with Cold Spring Harbor Laboratory in the United States and has a research focus within the broad field of Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields including Molecular Biology, Genetics, Plant Science, Cancer Research, and Ecology, Evolution, Behavior and Systematics.

The primary topics of Adam Siepel's research include:

  • Genomics and Phylogenetic Studies
  • RNA Research and Splicing
  • Evolution and Genetic Dynamics
  • RNA and protein synthesis mechanisms
  • Chromosomal and Genetic Variations
  • RNA modifications and cancer
  • Genetic Mapping and Diversity in Plants and Animals

Notable recent papers authored or co-authored by Adam Siepel include:

  • "A community-maintained standard library of population genetic models," 2020, eLife
  • "Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph," 2020, PLoS Genetics
  • "Identification of constrained sequence elements across 239 primate genomes," 2023, Nature
  • "Genomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweeps," 2020, Proceedings of the National Academy of Sciences
  • "A Deep-Learning Approach for Inference of Selective Sweeps from the Ancestral Recombination Graph," 2021, Molecular Biology and Evolution

Their frequent co-authors include:

  • Yixin Zhao (13 publications)
  • Armin Scheben (12 publications)
  • Noah Dukler (8 publications)
  • Ziyi Mo (7 publications)
  • Ryan N. Gutenkunst (5 publications)

Adam Siepel's research has been published in several prominent venues, among which the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory) with 20 publications
  • PLoS Genetics, 3 publications
  • Nature, 3 publications
  • Molecular Biology and Evolution, 3 publications
  • Nature Communications, 3 publications

Their work in genetics and molecular biology has earned formal recognition with awards including:

  • Fellow of John Simon Guggenheim Memorial Foundation, 2012
  • Fellow of Alfred P. Sloan Foundation, 2009

Best Publications

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

    Adam Siepel;Gill Bejerano;Jakob Skou Pedersen;Angie S Hinrichs

  • The ENCODE (ENCyclopedia of DNA elements) Project

    E. A. Feingold;P. J. Good;M. S. Guyer;S. Kamholz

  • Detection of nonneutral substitution rates on mammalian phylogenies

    Katherine S. Pollard;Melissa J. Hubisz;Kate R. Rosenbloom;Adam Siepel

  • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

    Ladeana W. Hillier;Webb Miller;Ewan Birney;Wesley Warren

  • The UCSC Genome Browser Database: update 2006

    A. S. Hinrichs;D. Karolchik;R. Baertsch;G. P. Barber

  • Phylogenetic Hidden Markov Models

    Adam Siepel;David Haussler

  • Combining phylogenetic and hidden Markov models in biosequence analysis.

    Adam C. Siepel;David Haussler

  • Evolutionary and biomedical insights from the rhesus macaque genome

    Richard A. Gibbs;Jeffrey Rogers

  • A high-resolution map of human evolutionary constraint using 29 mammals.

    Kerstin Lindblad-Toh;Manuel Garber;Or Zuk;Michael F. Lin;Michael F. Lin

  • An RNA gene expressed during cortical development evolved rapidly in humans

    Katherine S Pollard;Sofie R Salama;Nelle Lambert;Marie-Alexandra Lambot

  • Comparative analyses of multi-species sequences from targeted genomic regions

    J. W. Thomas;J. W. Thomas;J. W. Touchman;R. W. Blakesley;G. G. Bouffard

  • Comparative and demographic analysis of orang-utan genomes.

    Devin P. Locke;LaDeana W. Hillier;Wesley C. Warren;Kim C. Worley

  • Genome Sequencing Highlights the Dynamic Early History of Dogs

    Adam H. Freedman;Ilan Gronau;Rena Schweizer;Diego Ortega-Del Vecchyo

  • Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

    Leighton J Core;André L Martins;Charles G Danko;Colin T Waters

  • Bayesian inference of ancient human demography from individual genome sequences

    Ilan Gronau;Melissa J Hubisz;Brad Gulko;Charles G Danko

  • Identification and classification of conserved RNA secondary structures in the human genome

    Jakob Skou Pedersen;Gill Bejerano;Adam C. Siepel;Kate R. Rosenbloom

  • Patterns of positive selection in six Mammalian genomes

    Carolin Kosiol;Tomáš Vinař;Rute R. da Fonseca;Melissa J. Hubisz

  • Forces Shaping the Fastest Evolving Regions in the Human Genome

    Katherine S Pollard;Sofie R Salama;Bryan King;Andrew D Kern

  • A distal enhancer and an ultraconserved exon are derived from a novel retroposon

    Gill Bejerano;Craig B. Lowe;Nadav Ahituv;Nadav Ahituv;Bryan King

Frequent Co-Authors

David Haussler
David Haussler University of California, Santa Cruz
Melissa J. Hubisz
Melissa J. Hubisz Cornell University
John T. Lis
John T. Lis Cornell University
Kerstin Lindblad-Toh
Kerstin Lindblad-Toh Uppsala University
Carlos Bustamante
Carlos Bustamante Stanford University
Webb Miller
Webb Miller Pennsylvania State University
Gill Bejerano
Gill Bejerano Stanford University
Kate R. Rosenbloom
Kate R. Rosenbloom University of California, Santa Cruz
Jakob Skou Pedersen
Jakob Skou Pedersen Aarhus University
Katherine S. Pollard
Katherine S. Pollard University of California, San Francisco

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