World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
118
Citations
46250
World Ranking
284
National Ranking
168

Research.com Recognitions

  • 2015 - Member of the National Academy of Sciences
  • 2013 - Fellow of the American Academy of Arts and Sciences
  • 2000 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1992 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John T. Lis is affiliated with Cornell University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with an emphasis on Molecular Biology, Plant Science, Genetics, Computational Theory and Mathematics, and Infectious Diseases.

The scientist's major research topics include:

  • Genomics and Chromatin Dynamics
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Plant Molecular Biology Research
  • Molecular Biology Techniques and Applications
  • Bioinformatics and Genomic Networks

Their recent publications cover a range of topics and appear in several notable venues. Examples of these papers include:

  • "A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets" (2022), published in Nature Biotechnology
  • "Prediction of histone post-translational modification patterns based on nascent transcription data" (2022), published in Nature Genetics
  • "Distinct properties and functions of CTCF revealed by a rapidly inducible degron system" (2021), published in Cell Reports
  • "A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers" (2022), published in Nature Biotechnology
  • "Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions" (2021), published in Molecular Cell

The scientist frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Biotechnology
  • The FASEB Journal
  • Nature Genetics
  • Cell Reports

Collaborations are a significant aspect of their work, with frequent co-authors including Haiyuan Yu, Abdullah Ozer, Philip Versluis, Mauricio I. Paramo, and Alexandra G. Chivu.

Over the course of their career, John T. Lis has received several recognitions, including:

  • Member of the National Academy of Sciences (2015)
  • Fellow of the American Academy of Arts and Sciences (2013)
  • Fellow of John Simon Guggenheim Memorial Foundation (2000)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1992)

Best Publications

  • Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

    Leighton J. Core;Joshua J. Waterfall;John T. Lis

  • Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

    Karen Adelman;John T. Lis

  • Getting up to speed with transcription elongation by RNA polymerase II

    Iris Jonkers;John T. Lis

  • The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

    Ann E. Rougvie;John T. Lis

  • Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing

    Hojoong Kwak;Nicholas J. Fuda;Leighton J. Core;John T. Lis

  • PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

    Kenichi Nishioka;Judd C. Rice;Kavitha Sarma;Hediye Erdjument-Bromage

  • PARP Goes Transcription

    W.Lee Kraus;John T Lis

  • Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

    Leighton J Core;André L Martins;Charles G Danko;Colin T Waters

  • The 4D nucleome project

    Job Dekker;Andrew S. Belmont;Mitchell Guttman;Victor O. Leshyk

  • NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1

    Mi Young Kim;Steven Mauro;Nicolas Gévry;John T. Lis

  • Defining mechanisms that regulate RNA polymerase II transcription in vivo

    Nicholas J. Fuda;M. Behfar Ardehali;John T. Lis

  • Breaking barriers to transcription elongation.

    Abbie Saunders;Leighton J Core;John T Lis

  • Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

    Iris Jonkers;Hojoong Kwak;John T Lis

  • Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA

    Brent D. Brower-Toland;Corey Lewis Smith;Richard C. Yeh;John T. Lis

  • A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

    Nasun Hah;Charles G. Danko;Leighton Core;Joshua J. Waterfall

  • Germline transformation used to define key features of heat-shock response elements

    Hua Xiao;John T. Lis

  • Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit.

    Olga Perisic;Hua Xiao;John T. Lis

  • In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.

    Eric B. Rasmussen;John T. Lis

  • Control of Transcriptional Elongation

    Hojoong Kwak;John T. Lis

  • Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

    John Lis;Carl Wu

Frequent Co-Authors

Harold G. Craighead
Harold G. Craighead Cornell University
Adam Siepel
Adam Siepel Cold Spring Harbor Laboratory
W. Lee Kraus
W. Lee Kraus The University of Texas Southwestern Medical Center
Hua Xiao
Hua Xiao Michigan State University
Karen Adelman
Karen Adelman Harvard University
Vivian G. Cheung
Vivian G. Cheung University of Michigan–Ann Arbor
Jeffrey A. Simon
Jeffrey A. Simon University of Minnesota
Peter J. Park
Peter J. Park Harvard University
David Shalloway
David Shalloway Cornell University
Danny Reinberg
Danny Reinberg University of Miami

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