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Molecular Biology

D-Index
53
Citations
14283
World Ranking
2365
National Ranking
1168

Overview

Karen Adelman is affiliated with Harvard University in the United States, focusing on research within the field of Biochemistry, Genetics, and Molecular Biology. Their work primarily spans molecular biology and extends into related subfields including pathology and forensic medicine, cancer research, oncology, and immunology.

The scientist's research topics cover various aspects of RNA and genetics, including:

  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • CRISPR and Genetic Engineering
  • Lymphoma Diagnosis and Treatment
  • Cancer-related molecular mechanisms research

Frequent coauthors in their collaborative work include Claudia A. Mimoso, Geoffrey M. Nelson, Benjamín Martín, Seth Goldman, and Eric J. Wagner.

Their publications are often found in prominent scientific journals and preprint servers, reflecting a consistent research output. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Blood
  • Cell
  • SSRN Electronic Journal

Selected recent papers illustrate the scope and focus of Karen Adelman's research contributions:

  • "Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq," 2022, Cell
  • "Evaluating Enhancer Function and Transcription," 2020, Annual Review of Biochemistry
  • "Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis," 2021, Molecular Cell
  • "Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination," 2020, Molecular Cell
  • "Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis," 2022, Molecular Cell

Best Publications

  • Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

    Karen Adelman;John T. Lis

  • RNA polymerase is poised for activation across the genome

    Ginger W Muse;Daniel A Gilchrist;Sergei Nechaev;Ruchir Shah

  • RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo.

    Julia Zeitlinger;Alexander Stark;Manolis Kellis;Joung Woo Hong

  • Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila

    Sergei Nechaev;David C. Fargo;Gilberto dos Santos;Liwen Liu

  • Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

    Leighton Core;Karen Adelman

  • Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation

    Daniel A. Gilchrist;Gilberto Dos Santos;David C. Fargo;Bin Xie

  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

    Bartlomiej Bartkowiak;Pengda Liu;Hemali P. Phatnani;Nicholas J. Fuda

  • Widespread transcriptional pausing and elongation control at enhancers

    Telmo Henriques;Telmo Henriques;Benjamin S. Scruggs;Michiko O. Inouye;Michiko O. Inouye;Ginger W. Muse

  • Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

    Kristel M. Dorighi;Tomek Swigut;Telmo Henriques;Natarajan V. Bhanu

  • NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly

    Daniel A. Gilchrist;Sergei Nechaev;Chanhyo Lee;Saikat Kumar B. Ghosh

  • Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation

    Sergei Nechaev;Karen Adelman

  • Defining the Status of RNA Polymerase at Promoters

    Leighton J. Core;Joshua J. Waterfall;Daniel A. Gilchrist;David C. Fargo

  • Stable Pausing by RNA Polymerase II Provides an Opportunity to Target and Integrate Regulatory Signals

    Telmo Henriques;Daniel A. Gilchrist;Sergei Nechaev;Michael Bern

  • Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior.

    Karen Adelman;Arthur La Porta;Thomas J. Santangelo;John T. Lis

  • Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin.

    Benjamin S. Scruggs;Daniel A. Gilchrist;Sergei Nechaev;Ginger W. Muse

  • PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.

    Erdem Sendinc;David Valle-Garcia;David Valle-Garcia;Abhinav Dhall;Abhinav Dhall;Hao Chen;Hao Chen

  • Pausing of RNA Polymerase II Regulates Mammalian Developmental Potential through Control of Signaling Networks

    Lucy H. Williams;George Fromm;Nolan G. Gokey;Telmo Henriques

  • Efficient Release from Promoter-Proximal Stall Sites Requires Transcript Cleavage Factor TFIIS

    Karen Adelman;Michael T. Marr;Janis Werner;Abbie Saunders

  • The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

    Nathan D. Elrod;Telmo Henriques;Kai Lieh Huang;Deirdre C. Tatomer

  • Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25.

    Karen Adelman;Julia Yuzenkova;Arthur La Porta;Nikolay Zenkin

Frequent Co-Authors

John T. Lis
John T. Lis Cornell University
Brian D. Strahl
Brian D. Strahl University of North Carolina at Chapel Hill
Robert J. Duronio
Robert J. Duronio University of North Carolina at Chapel Hill
A. Gregory Matera
A. Gregory Matera University of North Carolina at Chapel Hill
Julia Zeitlinger
Julia Zeitlinger Stowers Institute for Medical Research
Leonard I. Zon
Leonard I. Zon Harvard University
Yang Shi
Yang Shi University of Oxford
Karla M. Neugebauer
Karla M. Neugebauer Yale University
Peter J. Park
Peter J. Park Harvard University

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