What is he best known for?
The fields of study he is best known for:
- Gene
- Surgery
- Gene expression
His primary areas of investigation include Genetics, Histone code, Chromatin, Regulation of gene expression and RNA polymerase II.
In general Genetics study, his work on P-TEFb, Histone H2A, TAF2 and TAF4 often relates to the realm of MED1, thereby connecting several areas of interest.
His Histone code study combines topics in areas such as Histone methyltransferase, Histone H4, MSL complex, Molecular biology and Cell biology.
His study brings together the fields of DNA-binding protein and Chromatin.
His Regulation of gene expression research is multidisciplinary, incorporating perspectives in Acetyltransferase, Acetylation and Hox gene.
His work is dedicated to discovering how RNA polymerase II, Transcription are connected with Methyltransferase, RNA-Directed DNA Methylation, Promoter and Methylation and other disciplines.
His most cited work include:
- Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF (548 citations)
- Covalent modifications of histones during development and disease pathogenesis. (522 citations)
- AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia (408 citations)
What are the main themes of his work throughout his whole career to date?
Edwin R. Smith spends much of his time researching Cell biology, Genetics, Chromatin, RNA polymerase II and Histone.
His Cell biology study also includes
- Chromatin remodeling which is related to area like Epigenomics,
- Helicase most often made with reference to Nucleosome.
His studies deal with areas such as Stem cell, Transcription factor, Computational biology and Cellular differentiation as well as Chromatin.
His study in RNA polymerase II is interdisciplinary in nature, drawing from both Molecular biology, Transcription, Regulatory sequence and Transcription factor II D.
His biological study spans a wide range of topics, including RNA, MSL complex, RNA polymerase II holoenzyme and Histone code.
Edwin R. Smith has included themes like Methylation, Acetylation, Drosophila Protein and Chromodomain in his Histone study.
He most often published in these fields:
- Cell biology (36.90%)
- Genetics (35.71%)
- Chromatin (38.10%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (36.90%)
- Chromatin (38.10%)
- Enhancer (17.86%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Cell biology, Chromatin, Enhancer, Transcription and RNA polymerase II.
His Cell biology study combines topics in areas such as PRC2, DNA methylation, Mutation, Regulation of gene expression and Epigenetics.
The various areas that Edwin R. Smith examines in his Chromatin study include Histone, Computational biology and Transcriptional regulation.
RNA polymerase II is a subfield of Gene that Edwin R. Smith studies.
His Gene study necessitates a more in-depth grasp of Genetics.
His Promoter research is multidisciplinary, incorporating elements of Molecular biology and Immediate early protein.
Between 2016 and 2021, his most popular works were:
- Born to run: control of transcription elongation by RNA polymerase II (128 citations)
- Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. (83 citations)
- Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. (65 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Surgery
- Gene expression
His primary scientific interests are in Enhancer, Cell biology, Epigenetics, Regulation of gene expression and Gene.
His work in Enhancer is not limited to one particular discipline; it also encompasses Chromatin.
His Chromatin research is multidisciplinary, incorporating perspectives in H3K4me3 and Protein family.
H3K4me3 is a subfield of Genetics that Edwin R. Smith tackles.
His research in Cell biology intersects with topics in Histone H3, Cellular differentiation and Demethylase.
His research integrates issues of Molecular biology, Polymerase and Transcription factor in his study of Gene expression.
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