His primary areas of investigation include Genetics, Histone code, Chromatin, Regulation of gene expression and RNA polymerase II. In general Genetics study, his work on P-TEFb, Histone H2A, TAF2 and TAF4 often relates to the realm of MED1, thereby connecting several areas of interest. His Histone code study combines topics in areas such as Histone methyltransferase, Histone H4, MSL complex, Molecular biology and Cell biology.
His study brings together the fields of DNA-binding protein and Chromatin. His Regulation of gene expression research is multidisciplinary, incorporating perspectives in Acetyltransferase, Acetylation and Hox gene. His work is dedicated to discovering how RNA polymerase II, Transcription are connected with Methyltransferase, RNA-Directed DNA Methylation, Promoter and Methylation and other disciplines.
Edwin R. Smith spends much of his time researching Cell biology, Genetics, Chromatin, RNA polymerase II and Histone. His Cell biology study also includes
His study in RNA polymerase II is interdisciplinary in nature, drawing from both Molecular biology, Transcription, Regulatory sequence and Transcription factor II D. His biological study spans a wide range of topics, including RNA, MSL complex, RNA polymerase II holoenzyme and Histone code. Edwin R. Smith has included themes like Methylation, Acetylation, Drosophila Protein and Chromodomain in his Histone study.
His primary areas of study are Cell biology, Chromatin, Enhancer, Transcription and RNA polymerase II. His Cell biology study combines topics in areas such as PRC2, DNA methylation, Mutation, Regulation of gene expression and Epigenetics. The various areas that Edwin R. Smith examines in his Chromatin study include Histone, Computational biology and Transcriptional regulation.
RNA polymerase II is a subfield of Gene that Edwin R. Smith studies. His Gene study necessitates a more in-depth grasp of Genetics. His Promoter research is multidisciplinary, incorporating elements of Molecular biology and Immediate early protein.
His primary scientific interests are in Enhancer, Cell biology, Epigenetics, Regulation of gene expression and Gene. His work in Enhancer is not limited to one particular discipline; it also encompasses Chromatin. His Chromatin research is multidisciplinary, incorporating perspectives in H3K4me3 and Protein family.
H3K4me3 is a subfield of Genetics that Edwin R. Smith tackles. His research in Cell biology intersects with topics in Histone H3, Cellular differentiation and Demethylase. His research integrates issues of Molecular biology, Polymerase and Transcription factor in his study of Gene expression.
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Covalent modifications of histones during development and disease pathogenesis.
Sukesh R Bhaumik;Edwin Smith;Ali Shilatifard.
Nature Structural & Molecular Biology (2007)
Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF
Yali Dou;Thomas A. Milne;Thomas A. Milne;Alan J. Tackett;Edwin R. Smith.
The language of histone crosstalk.
Jung Shin Lee;Edwin Smith;Ali Shilatifard.
AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
Chengqi Lin;Edwin R. Smith;Hidehisa Takahashi;Ka Chun Lai.
Molecular Cell (2010)
The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation.
Edwin R. Smith;Edwin R. Smith;Antonio Pannuti;Weigang Gu;Arnd Steurnagel.
Molecular and Cellular Biology (2000)
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.
Pengfei Wang;Chengqi Lin;Edwin R. Smith;Hong Guo.
Molecular and Cellular Biology (2009)
ESA1 is a histone acetyltransferase that is essential for growth in yeast
E. R. Smith;A. Eisen;Weigang Gu;M. Sattah.
Proceedings of the National Academy of Sciences of the United States of America (1998)
The super elongation complex (SEC) and MLL in development and disease.
Edwin Smith;Chengqi Lin;Ali Shilatifard.
Genes & Development (2011)
Human Mediator Subunit Med26 Functions As A Docking Site For Transcription Elongation Factors
Hidehisa Takahashi;Tari J. Parmely;Shigeo Sato;Chieri Tomomori-Sato.
A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16
Edwin R. Smith;Christelle Cayrou;Rong Huang;William S. Lane.
Molecular and Cellular Biology (2005)
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