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Genetics
USA
2026
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Molecular Biology
USA
2026

D-Index & Metrics

Genetics

D-Index
159
Citations
124488
World Ranking
100
National Ranking
50

Molecular Biology

D-Index
159
Citations
124488
World Ranking
65
National Ranking
44

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2015 - Genetics Society of America Medal
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2005 - Member of the National Academy of Sciences

Overview

Steven Henikoff is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily falls within Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Plant Science, Cancer Research, Genetics, and Oncology as subfields. The main topics of their work include Genomics and Chromatin Dynamics, Epigenetics and DNA Methylation, RNA Research and Splicing, RNA modifications and cancer, Chromosomal and Genetic Variations, Single-cell and spatial transcriptomics, and Cancer Genomics and Diagnostics.

Henikoff has contributed to a number of scientific publications, notably including:

  • Efficient low-cost chromatin profiling with CUT&Tag, 2020, Nature Protocols
  • What makes a centromere?, 2020, Experimental Cell Research
  • Sequence, Chromatin and Evolution of Satellite DNA, 2021, International Journal of Molecular Sciences
  • Histone variants at a glance, 2021, Journal of Cell Science
  • Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression, 2021, Nature Biotechnology

The scientist frequently collaborates with several other researchers, including Kami Ahmad, Derek H. Janssens, Jay F. Sarthy, Paul B. Talbert, and Michael P. Meers.

Henikoff has a substantial record of publication venues, with the most frequent being bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, eLife, and Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature.

Among awards received by Henikoff are the Genetics Society of America Medal (2015), Fellowship of the American Association for the Advancement of Science (AAAS) awarded in 2012, and membership in the National Academy of Sciences since 2005.

Best Publications

  • Amino acid substitution matrices from protein blocks

    Steven Henikoff;Jorja G. Henikoff

  • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.

    Prateek Kumar;Steven Henikoff;Steven Henikoff;Pauline C Ng;Pauline C Ng

  • SIFT: predicting amino acid changes that affect protein function

    Pauline C. Ng;Steven Henikoff

  • Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

    Steven Henikoff

  • Predicting Deleterious Amino Acid Substitutions

    Pauline C. Ng;Steven Henikoff

  • The epigenetic progenitor origin of human cancer

    Andrew P. Feinberg;Rolf Ohlsson;Steven Henikoff

  • SIFT web server: predicting effects of amino acid substitutions on proteins

    Ngak-Leng Sim;Prateek Kumar;Jing Hu;Steven Henikoff

  • Comparative Genomics of the Eukaryotes

    Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor

  • Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription

    Daniel Zilberman;Mary Gehring;Mary Gehring;Robert K Tran;Robert K Tran;Robert K Tran;Tracy Ballinger;Tracy Ballinger

  • CUT&Tag for efficient epigenomic profiling of small samples and single cells

    Hatice S. Kaya-Okur;Steven J. Wu;Steven J. Wu;Christine A. Codomo;Erica S. Pledger

  • An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

    Peter J Skene;Steven Henikoff

  • The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.

    Kami Ahmad;Steven Henikoff

  • The centromere paradox: stable inheritance with rapidly evolving DNA.

    Steven Henikoff;Kami Ahmad;Harmit S. Malik

  • Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

    Sushmita Roy;Jason Ernst;Peter V. Kharchenko;Pouya Kheradpour

  • Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

    Mark B. Gerstein;Zhi John Lu;Eric L. Van Nostrand;Chao Cheng

  • Targeting induced local lesions IN genomes (TILLING) for plant functional genomics.

    Claire M. McCallum;Luca Comai;Elizabeth A. Greene;Steven Henikoff;Steven Henikoff

  • Predicting the Effects of Amino Acid Substitutions on Protein Function

    Pauline C. Ng;Steven Henikoff

  • Regulation of nucleosome dynamics by histone modifications

    Gabriel E Zentner;Steven Henikoff

  • Unidirectional digestion with exonuclease III in DNA sequence analysis.

    Steven Henikoff

  • Author response: An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

    Peter J Skene;Steven Henikoff

Frequent Co-Authors

Luca Comai
Luca Comai University of California, Davis
Lincoln Stein
Lincoln Stein Ontario Institute for Cancer Research
Mark Gerstein
Mark Gerstein Yale University
Harmit S. Malik
Harmit S. Malik Fred Hutchinson Cancer Research Center
Shmuel Pietrokovski
Shmuel Pietrokovski Weizmann Institute of Science
Michael Snyder
Michael Snyder Stanford University
Suzanna E. Lewis
Suzanna E. Lewis Lawrence Berkeley National Laboratory
Fabio Piano
Fabio Piano New York University
Eran Segal
Eran Segal Weizmann Institute of Science
Chao Cheng
Chao Cheng Baylor College of Medicine

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