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Biology and Biochemistry

D-Index
68
Citations
46878
World Ranking
7602
National Ranking
589

Overview

Michael J. Clague is affiliated with the University of Liverpool in the United Kingdom. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Significant subfields within their work include Molecular Biology, Epidemiology, Immunology, Cell Biology, and Oncology.

Clague's research topics cover diverse areas with a particular focus on ubiquitin and proteasome pathways and autophagy in disease and therapy. Other central topics include mitochondrial function and pathology, peptidase inhibition and analysis, cellular transport and secretion, interferon and immune responses, and Parkinson's disease mechanisms and treatments.

They have published extensively in various scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Life Science Alliance
  • The Journal of Cell Biology
  • Biochemical Journal
  • Molecular Cell

Recent papers authored or co-authored by Clague include:

  • "USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation," 2020, Life Science Alliance
  • "Protein degradation on the global scale," 2022, Molecular Cell
  • "Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy," 2021, Life Science Alliance
  • "FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels," 2023, The EMBO Journal
  • "The deubiquitylase USP9X controls ribosomal stalling," 2020, The Journal of Cell Biology

Collaborative relationships are also notable in Clague's career. Frequent co-authors include:

  • Sylvie Urbé
  • Emma V. Rusilowicz-Jones
  • Francesco G. Barone
  • Heather Mortiboys
  • Hannah Elcocks

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Breaking the chains: structure and function of the deubiquitinases.

    David Komander;Michael J. Clague;Sylvie Urbé

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

    Hannah E.J. Polson;Jane de Lartigue;Daniel J. Rigden;Marco Reedijk

  • Breaking the chains: deubiquitylating enzyme specificity begets function.

    Michael J Clague;Sylvie Urbé;David Komander

  • Ubiquitin: same molecule, different degradation pathways.

    Michael J. Clague;Sylvie Urbé

  • Vacuolar ATPase activity is required for endosomal carrier vesicle formation.

    Michael J. Clague;Sylvie Urbé;Fernando Aniento;Jean Gruenberg

  • Deubiquitylases From Genes to Organism

    Michael J. Clague;Igor Barsukov;Judy M. Coulson;Han Liu

  • AMSH is an endosome-associated ubiquitin isopeptidase

    John McCullough;Michael J. Clague;Sylvie Urbé

  • Molecular basis of USP7 inhibition by selective small-molecule inhibitors

    Andrew P. Turnbull;Stephanos Ioannidis;Wojciech W. Krajewski;Adan Pinto-Fernandez

  • Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC

    Mary K Doherty;Dean E Hammond;Michael J Clague;Simon J Gaskell

  • The demographics of the ubiquitin system.

    Michael J. Clague;Claire Heride;Sylvie Urbé

  • Endocytosis: the DUB version.

    Michael J. Clague;Sylvie Urbé

  • Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

    Juliette J. Lee;Alvaro Sanchez-Martinez;Aitor Martinez Zarate;Aitor Martinez Zarate;Cristiane Benincá

  • The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation

    Paula E. Row;Ian A. Prior;John McCullough;Michael J. Clague

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes

    Ian G. Mills;Arwyn T. Jones;Michael J. Clague

  • PIKfyve Regulation of Endosome‐Linked Pathways

    Jane de Lartigue;Hannah Polson;Morri Feldman;Kevan Shokat

Frequent Co-Authors

Sylvie Urbé
Sylvie Urbé University of Liverpool
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Ian A. Prior
Ian A. Prior University of Liverpool
Ian G. Mills
Ian G. Mills University of Oxford
Sergio Lavandero
Sergio Lavandero University of Chile
Daniel J. Rigden
Daniel J. Rigden University of Liverpool
Richard J. Cherry
Richard J. Cherry University of Essex
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Evelina Gatti
Evelina Gatti Aix-Marseille University
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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