Member of the European Molecular Biology Organization (EMBO)
Jean Gruenberg spends much of his time researching Cell biology, Endosome, Endocytic cycle, Endocytosis and Vesicle. The various areas that Jean Gruenberg examines in his Cell biology study include Membrane and Biochemistry. His Endosome study incorporates themes from Cytoplasm, Lipid bilayer fusion, Late endosome and Membrane transport.
His work carried out in the field of Endocytic cycle brings together such families of science as Biological membrane, GTP', Small GTPase and Cytosol. His Endocytosis research incorporates themes from Cell polarity, Protein targeting and Cell Compartmentation. His Vesicle research is multidisciplinary, relying on both Kinesin, Lysosome, Niemann–Pick disease and Homeostasis.
Jean Gruenberg mainly focuses on Cell biology, Endosome, Endocytic cycle, Endocytosis and Vesicle. His Cell biology research incorporates elements of Membrane, Biochemistry and Membrane transport. His work focuses on many connections between Endosome and other disciplines, such as Lysosome, that overlap with his field of interest in Secretion.
In his research, G protein is intimately related to Rab, which falls under the overarching field of Endocytic cycle. His Endocytosis study combines topics in areas such as Small GTPase, Transmembrane protein, Cholesterol, Intracellular and Internalization. His Vesicle study integrates concerns from other disciplines, such as Golgi apparatus, Vesicular stomatitis virus, Endocytic vesicle and Kinesin.
His scientific interests lie mostly in Cell biology, Endosome, Endocytosis, Vesicle and ESCRT. His research on Cell biology frequently connects to adjacent areas such as Secretion. Jean Gruenberg combines subjects such as Transport protein, Endocytic cycle and Lysosome with his study of Endosome.
His work deals with themes such as Multivesicular Body, Chloride channel and Signal transduction, MAPK/ERK pathway, which intersect with Endocytic cycle. His Endocytosis course of study focuses on Cholesterol and Phospholipid. His work investigates the relationship between Organelle and topics such as Cell that intersect with problems in Mitochondrial fission and Endoplasmic reticulum.
His primary scientific interests are in Cell biology, Endosome, Endocytosis, Endocytic cycle and ESCRT. His research integrates issues of Biochemistry, Systems biology and Cytosol in his study of Cell biology. His studies deal with areas such as Vesicle, Lysosome, Membrane lipids and Flux as well as Endosome.
Jean Gruenberg studies Late endosome which is a part of Endocytosis. His study in Endocytic cycle is interdisciplinary in nature, drawing from both Signal transducing adaptor protein, Exocytosis, Secretion, LAMP1 and Secretory pathway. Jean Gruenberg combines subjects such as Plasma protein binding and Cell membrane with his study of ESCRT.
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rab5 controls early endosome fusion in vitro.
Jean-Pierre Gorvel;Philippe Chavrier;Marino Zerial;Jean Gruenberg.
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
Harald Alfred Stenmark;Robert G. Parton;Olivia Steele-Mortimer;Anne Lütcke.
The EMBO Journal (1994)
The endocytic pathway: a mosaic of domains
Nature Reviews Molecular Cell Biology (2001)
The biogenesis of multivesicular endosomes
Jean Gruenberg;Harald Stenmark.
Nature Reviews Molecular Cell Biology (2004)
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
T Kobayashi;E Stang;K S Fang;P de Moerloose.
Membrane transport in the endocytic pathway
Jean Gruenberg;Frederick R Maxfield.
Current Opinion in Cell Biology (1995)
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
Hirotami Matsuo;Julien Chevallier;Nathalie Mayran;Isabelle Le Blanc.
Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.
J Gruenberg;G Griffiths;K E Howell.
Journal of Cell Biology (1989)
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport
Toshihide Kobayashi;Marie-Hélène Beuchat;Margaret Lindsay;Sonia Frias.
Nature Cell Biology (1999)
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
Rutilio A. Fratti;Jonathan M. Backer;Jean Gruenberg;Silvia Corvera.
Journal of Cell Biology (2001)
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