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Frederick R. Maxfield

Frederick R. Maxfield

D-Index & Metrics

Biology and Biochemistry

D-Index
115
Citations
43087
World Ranking
800
National Ranking
503

Overview

Frederick R. Maxfield is affiliated with Cornell University in the United States, contributing extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans several interrelated subfields including molecular biology, physiology, surgery, cell biology, and neurology. The scientist has a notable focus on topics such as lipoproteins and cardiovascular health, lysosomal storage disorders research, neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, caveolin-1 and cellular processes, lipid membrane structure and behavior, and RNA interference and gene delivery.

Maxfield's recent research outputs include studies published in high-profile journals. Some of these are:

  • "Cholesterol and matrisome pathways dysregulated in astrocytes and microglia," 2022, Cell
  • "A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination," 2020, Brain
  • "Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis," 2020, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • "Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes," 2022, Journal of Biological Chemistry
  • "The formation and consequences of cholesterol-rich deposits in atherosclerotic lesions," 2023, Frontiers in Cardiovascular Medicine

Frederick R. Maxfield frequently collaborates with several researchers, including:

  • J. Cheng-I
  • Nina H. Pipalia
  • Noah Steinfeld
  • Santiago Solé-Domènech
  • Weixiang A Wang

The scientist's work regularly appears in selected publication venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Journal of Biological Chemistry
  • ACS Pharmacology & Translational Science
  • Cell Reports Methods

Best Publications

  • Role of cholesterol and lipid organization in disease.

    Frederick R. Maxfield;Ira Tabas

  • Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

    H.T. Haigler;F.R. Maxfield;M.C. Willingham;I. Pastan

  • Membrane transport in the endocytic pathway

    Jean Gruenberg;Frederick R Maxfield

  • Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

    Donata M. Paresce;Richik N. Ghosh;Frederick R. Maxfield;Frederick R. Maxfield

  • Rapid acidification of endocytic vesicles containing α2-macroglobulin

    Benjamin Tycko;Frederick R. Maxfield

  • Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

    Darrell J. Yamashiro;Benjamin Tycko;Sharon R. Fluss;Frederick R. Maxfield

  • Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts.

    Frederick R. Maxfield

  • Ca 2+ - and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

    Moira A. Lawson;Frederick R. Maxfield

  • Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process

    S Mayor;J F Presley;F R Maxfield

  • Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking

    Satyajit Mayor;Karen G. Rothberg;Frederick R. Maxfield

  • Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.

    Peter J. A. Davies;Dana R. Davies;Alexander Levitzki;Alexander Levitzki;Frederick R. Maxfield

  • Legionella pneumophila inhibits acidification of its phagosome in human monocytes.

    M A Horwitz;F R Maxfield

  • Intracellular cholesterol transport

    Frederick R. Maxfield;Daniel Wüstner

  • Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome.

    Kenneth Dunn;T. E. McGraw;F. R. Maxfield

  • Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails.

    Sushmita Mukherjee;Thwe Thwe Soe;Frederick R. Maxfield

  • Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

    Frederick R. Maxfield;Joseph Schlessinger;Joseph Schlessinger;Yoram Shechter;Ira Pastan

  • Cholesterol, the central lipid of mammalian cells.

    Frederick R Maxfield;Gerrit van Meer

  • Cholesterol depletion induces large scale domain segregation in living cell membranes

    Mingming Hao;Sushmita Mukherjee;Frederick R. Maxfield

  • Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

    A. W. M. Van Weert;K. W. Dunn;H. J. Geuze;F. R. Maxfield

  • Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog.

    Sushmita Mukherjee;Xiaohui Zha;Ira Tabas;Frederick R. Maxfield

Frequent Co-Authors

Ira Tabas
Ira Tabas Columbia University
Harold A. Scheraga
Harold A. Scheraga Cornell University
Ira Pastan
Ira Pastan Center for Cancer Research
Mark C. Willingham
Mark C. Willingham Wake Forest University
Timothy E. McGraw
Timothy E. McGraw Cornell University
Satyajit Mayor
Satyajit Mayor National Centre for Biological Sciences
Timothy Hla
Timothy Hla Harvard University
Olaf Wiest
Olaf Wiest University of Notre Dame
Benjamin Tycko
Benjamin Tycko Hackensack University Medical Center
Rajiv R. Ratan
Rajiv R. Ratan Cornell University

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